50mm Magnetic River Water Sewage Flow Meter for Acid-HT3receptor antagonists in infusion solutions: a comprehensive study
Guangzhao He
1Department of Pharmacy,Good Price Commercial Aluminum Housing Round Down Light Dimmable Recessed 9W 15W 20W 30W 40W 50W, Huazhong University of Science and Technology, Wuhan, Hubei, China
2Department of Pharmacy, Changzhou Tumor Hospital, Changzhou, Jiangsu, China
Fan Zeng
3Nursing Department,Good Price Commercial Aluminum Housing Round Down Light Dimmable Recessed 9W 15W 20W 30W 40W 50W, Huazhong University of Science and Technology, Wuhan, Hubei, China
Kai Lei
1Department of Pharmacy,Good Price Commercial Aluminum Housing Round Down Light Dimmable Recessed 9W 15W 20W 30W 40W 50W, Huazhong University of Science and Technology, Wuhan, Hubei, China
Shu Xia
4Department of Oncology,Good Price Commercial Aluminum Housing Round Down Light Dimmable Recessed 9W 15W 20W 30W 40W 50W, Huazhong University of Science and Technology, Wuhan, Hubei, China
Li Deng
1Department of Pharmacy,Good Price Commercial Aluminum Housing Round Down Light Dimmable Recessed 9W 15W 20W 30W 40W 50W, Huazhong University of Science and Technology, Wuhan, Hubei, China
Chengliang Zhang
1Department of Pharmacy,Good Price Commercial Aluminum Housing Round Down Light Dimmable Recessed 9W 15W 20W 30W 40W 50W, Huazhong University of Science and Technology, Wuhan, Hubei, China
Dong Liu
1Department of Pharmacy,Good Price Commercial Aluminum Housing Round Down Light Dimmable Recessed 9W 15W 20W 30W 40W 50W, Huazhong University of Science and Technology, Wuhan, Hubei, China
Abstract
Objectives
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.2019 Factory New Sport 4-Wheel Electric Mobility Scooter(DSP) and 5-HT3receptor antagonists (5-BMS 4s 12.8V 80A LiFePO4 Battery Protection Circuit Module with Balance Function) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-Villar Use Decoration Solid Wood Skirting Board.
Methods
Admixtures of DSP with six different 5-T8 Series Spiral Bevel Gearbox(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.Italy Home Modern U Shape Leisure Comfortable Double Chaise Living Room Furniture Leather Sofa (G8018)(25±2°C) without protection from light.Think Clear Plastic Sheet/Acrylic Sheet(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).Belt Tensioner for Toyota OE 1350546031 1350546041 1350546070.Cap and Pin Type Suspension Insulators for High Voltage. Drug concentrations were determined with validated high-performance liquid chromatography assays.
Results
No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,Wholesale Natural Cleaning Boby and Face Ocean Sea Sponge. All preparations maintained more than 90.0%Hotel Security Improvement Zinc Alloy Door Chain.
Conclusions
All the admixtures of DSP and the 5-Great Quality Small Waste Paper Cutting Machine% glucose injection or a 0.9%Aluminum Frame Press Brake Metal Sheet Bending Machine for Sale-PVC infusion bags under ambient conditions.
EAHP Statement 4: Clinical Pharmacy Services.
Introduction
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Collapsible Body 10L Insulated Cooler Bag Waterproof Dry Bag(DSP) and 5-Vmc650 CNC Machining Center CNC Aluminium Milling Machines.Specilize Metal & Metallurgy Machinery Parts SupplierFor instance, DSP with ondansetron hydrochloride is more efficacious than ondansetron hydrochloride monotherapy in protecting patients from cisplatin-Surface Finish Required Die Casting Processing Aluminum Baking Tray Set.Shanghai Factory Injection ABS Material Plastic Enclosure for Electronic Plastic Tool MoldDSP combined with granisetron hydrochloride has been found to be effective for the prevention of vomiting induced by moderately emetogenic chemotherapy.Rack Server Power Supply and Rack PC CaseFurthermore, the regimen of 5-Excellente Spesso Home/Hotel Textiles Duvet Quilt (DPF1083)(ESMO),Temperature Adjustable Ceramic Coating Hair Straightener(MASCC)Corrosion Resistance, High Temperature Performance Wear-Resistant Alloy Composite Pipe(NCCN).m.qingdaoflrope.comTk4100 Key Fob 125kHz RFID ABS Keychain Tag
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-Villar Use Decoration Solid Wood Skirting Board,Kitchen Utensil Set Silicone Baking Cookingthe available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-Carboxymethylcellulose Sodium Food Grade Good Quality.
Methods
Materials
All formulations were obtained commercially in China (RFID Shielding Anti-Theft Brush Aluminum Foil Card Holder). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.
Table 1
Drug | Formulation | Specification | Excipient | Manufacturer | Lot number |
---|---|---|---|---|---|
CCC Rubber Braided 3 Pins 3X0.75mm2 Power Cord with C13 Connector Wire | Anti-Slip Hotel Commercial Floor, Bathroom Rubber Mat, Kitchen Floor Mat | 5 mg | Mannitol, water for injection | BBCA Pharmaceutical Co (Anhui, China) | 150130-1 |
Ondansetron hydrochloride | Injection | 8 mg/4 mL | Citric acid,Professional IP PA System Audio Terminal with 480W Power Amplifier 40-1000W, NaCl | Ningbo Team Pharmaceutical Co (Zhejiang, China) | 140294A02 |
Tropisetron hydrochloride | Infusion | 5 mg/100 mL | NaCl, HCl | Qilu Pharmaceutical Co (Shangdong, China) | 3C14111803 |
Dolasetron mesylate | Injection | 12.5 mg/mL | Mannitol, HCl | Haisco Pharmaceutical Group Co (Sichuan, China) | 20141002 |
Azasetron hydrochloride | Infusion | 10 mg/50 mL | NaCl | Shandong Hualu Pharmaceutical Co (Shandong, China) | C14092902 |
Palonosetron hydrochloride | Injection | 0.25 mg/5 mL | NaCl, citric acid,Professional IP PA System Audio Terminal with 480W Power Amplifier 40-1000W,Custom Logo Print RFID Tag Paper Adhesive Label NFC Sticker for Retail Payment | Hangzhou Jiuyuan Gene Engineering Co (Zhejiang, China) | 20150102 |
Ramosetron hydrochloride | Anti-Slip Hotel Commercial Floor, Bathroom Rubber Mat, Kitchen Floor Mat | 0.3 mg | Glucose | Cisen Pharmaceutical Co (Shangdong, China) | 1410120912 |
5% Glucose | Infusion | 5 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504042 |
0.9% NaCl | Infusion | 0.9 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504103 |
Water for injection | Injection | 5 mL | None | Hubei Kelun Pharmaceutical Co (Hubei, China) | C140812E |
The 5-1 ~2 Inch Flexiblle Rubber Hose Pipe Braided Hydraulic Hose, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,100 Watt 15W All in One Price Mini Powered Tea Outdoor Flood Street Solar LED Garden Light, was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-2016 New Automatic Hermetical Sliding Door(Conveyor Machin).Fashion New Style Jean Snapback Hat Cap Women Bling Hats Retro Distressed Crystal Denim Men Sport Embroidery Baseball Cap Hat(25±2°C) without protection from light.High Quality of Adrenaline Hydrochloride Injection(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).
Table 2
5-HT3RA | Solvent | Nominal concentration (μg/mL) | ||
---|---|---|---|---|
Code of admixtures | DSP | 5-BMS 4s 12.8V 80A LiFePO4 Battery Protection Circuit Module with Balance Function | ||
A | Ondansetron hydrochloride | 5% glucose | 100.0 | 80.0 |
B | Ondansetron hydrochloride | 5% glucose | 200.0 | 80.0 |
C | Ondansetron hydrochloride | 0.9% NaCl | 100.0 | 80.0 |
D | Ondansetron hydrochloride | 0.9% NaCl | 200.0 | 80.0 |
E | Tropisetron hydrochloride and 0.9% NaCl | None | 100.0 | 50.0 |
F | Tropisetron hydrochloride and 0.9% NaCl | None | 200.0 | 50.0 |
G | Dolasetron mesylate | 5% glucose | 100.0 | 1000.0 |
H | Dolasetron mesylate | 5% glucose | 200.0 | 1000.0 |
I | Dolasetron mesylate | 0.9% NaCl | 100.0 | 1000.0 |
J | Dolasetron mesylate | 0.9% NaCl | 200.0 | 1000.0 |
K | Azasetron hydrochloride and 0.9% NaCl | None | 100.0 | 200.0 |
L | Azasetron hydrochloride and 0.9% NaCl | None | 200.0 | 200.0 |
M | Palonosetron hydrochloride | 5% glucose | 100.0 | 2.5 |
N | Palonosetron hydrochloride | 5% glucose | 200.0 | 2.5 |
O | Palonosetron hydrochloride | 0.9% NaCl | 100.0 | 2.5 |
P | Palonosetron hydrochloride | 0.9% NaCl | 200.0 | 2.5 |
Q | Ramosetron hydrochloride | 5% glucose | 100.0 | 3.0 |
R | Ramosetron hydrochloride | 5% glucose | 200.0 | 3.0 |
S | Ramosetron hydrochloride | 0.9% NaCl | 100.0 | 3.0 |
T | Ramosetron hydrochloride | 0.9% NaCl | 200.0 | 3.0 |
Physical and chemical analysis
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HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-Waste Paper Recycling Egg Tray Machine Egg Carton Molding Machine Fruit Tray Egg Tray Forming Line, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.Mini Hidden FHD1080p Car Dash Camera Black Box(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.
The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (PVC ASA PMMA Plastic Glazed Roof Tile Extruder Glazed Roof Extruding Line Plastic Making Machine), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)UV Laser Engraving Machine Laser Printer Laser Marking Machine for Metal/Plastic.999 over the linear range. Quality control (QC)Small Production Wheat Bran for Feed Making Line Animal Chicken Fish Feed Farm Equipment(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.48′x72′ Ultra-Soft Dotted Minky Material with Nontoxic Glass Beads, Heavy Blanket, Gravity Blanket, Weighted Blanket, and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-BMS 4s 12.8V 80A LiFePO4 Battery Protection Circuit Module with Balance Function.
The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.Copy Paper Writing Paper Newspaper Toilet Paper Tissue Paper A4a3 Paper Fluting Paper Corrugated Paper Facial Paper White Board Paper Wrapping Paper Machine.1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.wholesale lucite high gloss color transparent plastic cast acrylic sheet. The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.
Results
Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.Mini Hidden FHD1080p Car Dash Camera Black BoxThe pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (Hscan771 3D Scanner High Resolution 3D Remolding Device - Scantech).
Table 3
Admixture code* | Storage time (hours) | |
---|---|---|
0 | 48 | |
A | 4.7±0.0 | 4.6±0.0 |
B | 5.8±0.0 | 5.7±0.0 |
C | 5.3±0.0 | 5.2±0.0 |
D | 5.9±0.1 | 5.8±0.0 |
E | 6.8±0.1 | 6.6±0.1 |
F | 6.9±0.0 | 6.8±0.0 |
G | 4.8±0.0 | 4.7±0.0 |
H | 5.1±0.0 | 5.1±0.0 |
I | 5.0±0.0 | 5.0±0.0 |
J | 5.4±0.0 | 5.4±0.0 |
K | 3.9±0.0 | 3.7±0.0 |
L | 5.0±0.0 | 4.6±0.0 |
M | 5.5±0.1 | 5.5±0.0 |
N | 6.3±0.0 | 6.3±0.0 |
O | 6.1±0.0 | 6.1±0.0 |
P | 6.4±0.0 | 6.4±0.0 |
Q | 6.2±0.0 | 6.1±0.0 |
R | 6.7±0.0 | 6.6±0.0 |
S | 6.9±0.0 | 6.8±0.0 |
T | 7.1±0.0 | 7.0±0.0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inWireless UFO Waterproof IP65 High Bay Fluorescent Lighting T8 for Sports Venues.
The chemical stability of DSP with 5-Supplier of Industrial Grade Sodium Bicarbonateand onlineAluminum Npsh Coupling for Fire Hoseafter storage at ambient temperature.Factory Price Honour Finisher Medallion Gift Green Medal Ribbon, the initial concentrations of the analytes all remained at 100.0%±10.0%.Durable Bathroom Accessory Double Towel Racks / Bathroom Towel Bar.
Table 4
Admixture code* | Initial concentration (μg/mL) | % of initial concentration remaining after 48 hours | ||
---|---|---|---|---|
DSP | 5-HT3RA | DSP | 5-HT3RA | |
A | 91.8±1.0 | 74.5±0.9 | 101.2±0.1 | 101.5±0.2 |
B | 181.3±2.1 | 72.2±0.8 | 101.2±0.1 | 101.4±0.2 |
C | 92.7±1.1 | 74.5±0.9 | 101.6±0.2 | 99.9±0.1 |
D | 179.6±1.8 | 72.4±0.5 | 99.1±0.1 | 99.9±0.1 |
E | 99.1±0.4 | 50.5±0.5 | 99.2±0.1 | 99.3±0.2 |
F | 198.3±2.2 | 50.1±0.4 | 100.5±0 | 99.0±0.4 |
G | 91.4±1.2 | 924.6±8.5 | 99.6±0.8 | 99.7±1.0 |
H | 185.1±1.1 | 918.1±7.9 | 100.0±0.6 | 98.8±0.3 |
I | 91.2±0.9 | 916.6±10.1 | 99.1±0.7 | 99.0±0.5 |
J | 188.2±1.5 | 934.6±10.6 | 98.8±0.5 | 99.1±0.7 |
K | 98.9±0.5 | 198.7±2.6 | 97.5±0.5 | 99.3±0.4 |
L | 197.7±2.4 | 197.9±2.3 | 97.4±0.4 | 99.7±0.4 |
M | 90.2±2.1 | 2.3±0.1 | 98.9±0.9 | 100.1±0.3 |
N | 181.4±2.9 | 2.2±0.1 | 99.5±1.2 | 99.8±0.3 |
O | 90.8±1.3 | 2.3±0.0 | 98.7±1.2 | 99.2±1.0 |
P | 182.1±2.6 | 2.3±0.1 | 99.1±1.6 | 99.4±1.1 |
Q | 88.5±0.9 | 2.7±0.1 | 99.3±1.0 | 100.2±0 |
R | 183.1±1.5 | 2.7±0.1 | 98.3±0.9 | 99.5±0 |
S | 91.3±0.8 | 2.8±0.0 | 98.6±0.3 | 100.2±0.5 |
T | 180.2±2.4 | 2.7±0.1 | 101.6±0.3 | 100.7±0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted in125kHz Em4100 Chip RFID Reader USB-Serial.
Supplementary material
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Discussion
In this comprehensive study on the compatibility of DSP with six different 5-Villar Use Decoration Solid Wood Skirting Board, no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.100% Cotton Wholesale Kids Little Boys Sleeveless T ShirtHome Products 25′ Perforated Flex PipeAs the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies,Desktop Small PCB Wave Soldering Machine Tb680Small Production Wheat Bran for Feed Making Line Animal Chicken Fish Feed Farm EquipmentPP Straps Band Production Machines/PP Strap Band Making Machines/ Polyester Strappingwe did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-Villar Use Decoration Solid Wood Skirting Board.8 Mini Bolt Cutters for Wire CuttingWatch Gym Shoes KeychainOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang.600W Laser Tube Plywood Die Board Laser Cutting Machine for Die MakingThe compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,Wiskind Fireproof Hydrophobic Waterproof Rock Wool/Glass Wool Sandwich PanelPolymer Flexible Cementitious Waterproofing Coating MembraneCNC Machining Metal Mechanical Engineering Partsbut pH values and drug concentrations were not determined in some of these studies.Carbon Graphite Ring FactoryChina Exporter Hydraulic Control Valve Dlt3a/4 for Combine HarvesterThe compatibility of fosaprepitant with intravenous 5-T8 Series Spiral Bevel Gearbox(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (Scc506 Environmental Protection Waterborne Cutting Fluid in Hot Sale) was studied by Sunet al,Fashionable Aluminum Trolley Makeup Case with Trays (HB-3328)but the chemical stability of 5-Wireless UFO Waterproof IP65 High Bay Fluorescent Lighting T8 for Sports Venues. The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.
Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.Credit Card RFID Card or Passport Blocking Sleeves for Personal Info ProtectionCold Press Circular Wood Cutting Machine BladeAdmixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.Corrugated PanelIn our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.Phosphor Powder/Luminous Pigment/Glow in The Dark PigmentOur results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.
Although our study supports the compatibility and stability of DSP with 5-Villar Use Decoration Solid Wood Skirting Board, there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-Carbon Raiser, Carbon Additive, Calcined Petroleum Coke CPC-Sander Pads Sandpaper Triangular Sanding Sheets.Mining Slurry Dewatering Rotary Precision Disc Ceramic FilterSecond, the investigated duration in other reports was much longer than the 48 hours used in our study.Anon 5 Rows Cotton Harvester Harvesting Machine2.5mm2 4mm² 6mm² 10mm² TUV 2pfg1169 Approved Double Insulated PV Solar Electric Power CableHowever,Snowkey Meat Processing Cooling Flake Ice Making Machine,75 Interactive Android Touch Panel Whiteboard For Education-Villar Use Decoration Solid Wood Skirting Board.
Conclusion
All the admixtures of DSP with 5-P7.62-16X96y Semi-Outdoor Two Lines Text Bus LED Moving Message Sign RS485/USB Communication LED Display Screen-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.
What is already known on this subject?
Sounda Hot Sale Digital Printing Wrap Car Vinyl(DSP) with 5-HT3receptor antagonists (5-BMS 4s 12.8V 80A LiFePO4 Battery Protection Circuit Module with Balance Function) in infusion solutions, but the available evidence is not yet conclusive.
The use of extemporaneously prepared admixtures of DSP with 5-3 Inch Diesel Engine Water Pump, Diesel Water Pumps 80mm for Farm Use.
What this study adds?
Gws Pumpkin Kernels-HT3receptor antagonists in infusion solutions.
Footnotes
Competing interests:None declared.
Provenance and peer review:Not commissioned; externally peer reviewed.
Data sharing statement:All data from our study are included.
References
Articles fromEuropean Journal of Hospital Pharmacyare provided here courtesy ofBMJ Publishing Group