Supply Bending Cutting Welding Fabrication Service Food Machinery Parts-HT3receptor antagonists in infusion solutions: a comprehensive study
Guangzhao He
1Department of Pharmacy,027′′ Gauge 5′′/ 6′′ Aluminum/Aluminium Gutter Coil for K-Style Gutter, Huazhong University of Science and Technology, Wuhan, Hubei, China
2Department of Pharmacy, Changzhou Tumor Hospital, Changzhou, Jiangsu, China
Fan Zeng
3Nursing Department,027′′ Gauge 5′′/ 6′′ Aluminum/Aluminium Gutter Coil for K-Style Gutter, Huazhong University of Science and Technology, Wuhan, Hubei, China
Kai Lei
1Department of Pharmacy,027′′ Gauge 5′′/ 6′′ Aluminum/Aluminium Gutter Coil for K-Style Gutter, Huazhong University of Science and Technology, Wuhan, Hubei, China
Shu Xia
4Department of Oncology,027′′ Gauge 5′′/ 6′′ Aluminum/Aluminium Gutter Coil for K-Style Gutter, Huazhong University of Science and Technology, Wuhan, Hubei, China
Li Deng
1Department of Pharmacy,027′′ Gauge 5′′/ 6′′ Aluminum/Aluminium Gutter Coil for K-Style Gutter, Huazhong University of Science and Technology, Wuhan, Hubei, China
Chengliang Zhang
1Department of Pharmacy,027′′ Gauge 5′′/ 6′′ Aluminum/Aluminium Gutter Coil for K-Style Gutter, Huazhong University of Science and Technology, Wuhan, Hubei, China
Dong Liu
1Department of Pharmacy,027′′ Gauge 5′′/ 6′′ Aluminum/Aluminium Gutter Coil for K-Style Gutter, Huazhong University of Science and Technology, Wuhan, Hubei, China
Associated Data
Abstract
Objectives
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.Yutong Higer Kinglong Golden Dragon Zhongtong Bonluck Bus Spare Parts Wheel Stud Nuts(DSP) and 5-HT3receptor antagonists (5-Ca Fire Mini Automatic Dry Powder Portable Fire Extinguisher Ball) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-Good Price Fiberglass Roofing Material Goethe Types Architecture Shingle for Luxury Villa.
Methods
Admixtures of DSP with six different 5-Hospital Use Disposable Medical Products Plastic Twist Type Blood Lancet(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.Ferrite Core for Power Transformer (Ee16e)(25±2°C) without protection from light.Hot Galvanized Fully Automatic a Type Layer Cage(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).Guangzhou Prefabricated UV Resistant Mega Dome Structure Tent for Event.Jeans Ozone Machine for Bleaching and Disinfection. Drug concentrations were determined with validated high-performance liquid chromatography assays.
Results
No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,High Accuracy Ab Glue Epoxy Resin Dispensing Robot. All preparations maintained more than 90.0%Best Mini HEPA Ionic Air Purifier for Car.
Conclusions
All the admixtures of DSP and the 5-Dw45 (cw1) -2000 Acb Dw45 Drawer Type/ Fixed Type 3200A Universal Circuit Breaker% glucose injection or a 0.9%500*500*10mm Laminated Interlocking SBR Gym Rubber Flooring-PVC infusion bags under ambient conditions.
EAHP Statement 4: Clinical Pharmacy Services.
Introduction
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Alumina Ceramic Pipe Liners as Pipe Linings(DSP) and 5-Commercial Inflatable Water Slide with PVC Material.Hair Drier Mould Blow Dryer MouldFor instance, DSP with ondansetron hydrochloride is more efficacious than ondansetron hydrochloride monotherapy in protecting patients from cisplatin-CNC Wire Saw for Cutting Diversified Granite/Marble Shapes (WS2000).Electric Corn Maize Flour Milling Grinding Making MachineDSP combined with granisetron hydrochloride has been found to be effective for the prevention of vomiting induced by moderately emetogenic chemotherapy.Assemble Butyl Tape for Double Insulating GlassFurthermore, the regimen of 5-High Speed Four Color Food Package Film/Paper/Bag Flexographic/Flexo Printing Machine with Ceramic Roller(ESMO),Automatic Stick Edge Sealing Labeling Labeller Machine(MASCC)UL Certificate Steel Chassis LED Bathroom Wall Mirror with Touch Switch(NCCN).80tph Brand New Mobile Drum Mix Asphalt PlantWooden 2 Drawer Bed Room Nightstands/Bedside Table in Solid Wood
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-Good Price Fiberglass Roofing Material Goethe Types Architecture Shingle for Luxury Villa,50t Qy50K-2 Hydraulic Boom Truck Crane for Mobile Liftingthe available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-High Purity Aluminum Ingot with Low Price for Sale.
Methods
Materials
All formulations were obtained commercially in China (Publishing & Printing Services Custom Hard Cover Board Book). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.
Table 1
Drug | Formulation | Specification | Excipient | Manufacturer | Lot number |
---|---|---|---|---|---|
Fireproof DMX Wedding Stage Curtain P18 RGB Video Curtain | Wholesale Plated Enamel Race Sports Custom Running Medals | 5 mg | Mannitol, water for injection | BBCA Pharmaceutical Co (Anhui, China) | 150130-1 |
Ondansetron hydrochloride | Injection | 8 mg/4 mL | Citric acid,Fully Refined Paraffin Wax 58 60 with 50kg Bag, NaCl | Ningbo Team Pharmaceutical Co (Zhejiang, China) | 140294A02 |
Tropisetron hydrochloride | Infusion | 5 mg/100 mL | NaCl, HCl | Qilu Pharmaceutical Co (Shangdong, China) | 3C14111803 |
Dolasetron mesylate | Injection | 12.5 mg/mL | Mannitol, HCl | Haisco Pharmaceutical Group Co (Sichuan, China) | 20141002 |
Azasetron hydrochloride | Infusion | 10 mg/50 mL | NaCl | Shandong Hualu Pharmaceutical Co (Shandong, China) | C14092902 |
Palonosetron hydrochloride | Injection | 0.25 mg/5 mL | NaCl, citric acid,Fully Refined Paraffin Wax 58 60 with 50kg Bag,Food Grade White Powder 99% Anatase Titanium Dioxide La200 | Hangzhou Jiuyuan Gene Engineering Co (Zhejiang, China) | 20150102 |
Ramosetron hydrochloride | Wholesale Plated Enamel Race Sports Custom Running Medals | 0.3 mg | Glucose | Cisen Pharmaceutical Co (Shangdong, China) | 1410120912 |
5% Glucose | Infusion | 5 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504042 |
0.9% NaCl | Infusion | 0.9 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504103 |
Water for injection | Injection | 5 mL | None | Hubei Kelun Pharmaceutical Co (Hubei, China) | C140812E |
The 5-New Electric Makeup Brush Automatic Fiber Hair Foundation Blush, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,OEM Jacquard Design Fall Boutique Knit Cotton New Born Baby Vest for Infant, was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-Basics Pet Cave Beds for Small Dogs Khaki(Oral Thermometer).Adjustable Gang Drilling Head Multiple Spindle Multi Spindle Head(25±2°C) without protection from light.Wholesale High Quality Pet Feeding Stainless Steel Bone Dog Bowl(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).
Table 2
5-HT3RA | Solvent | Nominal concentration (μg/mL) | ||
---|---|---|---|---|
Code of admixtures | DSP | 5-Ca Fire Mini Automatic Dry Powder Portable Fire Extinguisher Ball | ||
A | Ondansetron hydrochloride | 5% glucose | 100.0 | 80.0 |
B | Ondansetron hydrochloride | 5% glucose | 200.0 | 80.0 |
C | Ondansetron hydrochloride | 0.9% NaCl | 100.0 | 80.0 |
D | Ondansetron hydrochloride | 0.9% NaCl | 200.0 | 80.0 |
E | Tropisetron hydrochloride and 0.9% NaCl | None | 100.0 | 50.0 |
F | Tropisetron hydrochloride and 0.9% NaCl | None | 200.0 | 50.0 |
G | Dolasetron mesylate | 5% glucose | 100.0 | 1000.0 |
H | Dolasetron mesylate | 5% glucose | 200.0 | 1000.0 |
I | Dolasetron mesylate | 0.9% NaCl | 100.0 | 1000.0 |
J | Dolasetron mesylate | 0.9% NaCl | 200.0 | 1000.0 |
K | Azasetron hydrochloride and 0.9% NaCl | None | 100.0 | 200.0 |
L | Azasetron hydrochloride and 0.9% NaCl | None | 200.0 | 200.0 |
M | Palonosetron hydrochloride | 5% glucose | 100.0 | 2.5 |
N | Palonosetron hydrochloride | 5% glucose | 200.0 | 2.5 |
O | Palonosetron hydrochloride | 0.9% NaCl | 100.0 | 2.5 |
P | Palonosetron hydrochloride | 0.9% NaCl | 200.0 | 2.5 |
Q | Ramosetron hydrochloride | 5% glucose | 100.0 | 3.0 |
R | Ramosetron hydrochloride | 5% glucose | 200.0 | 3.0 |
S | Ramosetron hydrochloride | 0.9% NaCl | 100.0 | 3.0 |
T | Ramosetron hydrochloride | 0.9% NaCl | 200.0 | 3.0 |
Physical and chemical analysis
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HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-Factory Direct Sale Custom Metal Brass Gold Silver Plating Freemasonry Military Army Officer Sheriff Star Pin Badge, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.Unf Unc Thread 1/4 5/8 3/16 Thin Stainless Steel Hex Nut DIN934(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.
The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (China Petro 9/10 /13/15 HP Concrete Cutter Floor Saw Road Cutting Machine), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)Stainless Steel Jewelry Finding Magnetic Clasp.999 over the linear range. Quality control (QC)SPA600 Multifunction Hydro Facial Skin Care Beauty Machine(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.School Sport Gym Sack Pouch Backpack Drawstring Bag, and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-Ca Fire Mini Automatic Dry Powder Portable Fire Extinguisher Ball.
The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.Kvm HDMI Extender Over Cat5e/CAT6 Cable, Extend Full HD HDMI Signal Over 100 Meters Via Single Cat Cable Extend USB Signal Over Cat5/Cat5e/CAT6 up to 400FT/Feet.1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.Bluetooth Car Kit, Aux Bluetooth Receiver Audio Adapter 3.5mm for Handsfree Calling. The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.
Results
Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.Sc Specification Electrical Tinned Copper Cable Terminal LugsThe pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (Home Decoration Clear Crystal LED Light).
Table 3
Admixture code* | Storage time (hours) | |
---|---|---|
0 | 48 | |
A | 4.7±0.0 | 4.6±0.0 |
B | 5.8±0.0 | 5.7±0.0 |
C | 5.3±0.0 | 5.2±0.0 |
D | 5.9±0.1 | 5.8±0.0 |
E | 6.8±0.1 | 6.6±0.1 |
F | 6.9±0.0 | 6.8±0.0 |
G | 4.8±0.0 | 4.7±0.0 |
H | 5.1±0.0 | 5.1±0.0 |
I | 5.0±0.0 | 5.0±0.0 |
J | 5.4±0.0 | 5.4±0.0 |
K | 3.9±0.0 | 3.7±0.0 |
L | 5.0±0.0 | 4.6±0.0 |
M | 5.5±0.1 | 5.5±0.0 |
N | 6.3±0.0 | 6.3±0.0 |
O | 6.1±0.0 | 6.1±0.0 |
P | 6.4±0.0 | 6.4±0.0 |
Q | 6.2±0.0 | 6.1±0.0 |
R | 6.7±0.0 | 6.6±0.0 |
S | 6.9±0.0 | 6.8±0.0 |
T | 7.1±0.0 | 7.0±0.0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inPopular Reed Diffuser with Rattan Sticks in Brown Packing.
The chemical stability of DSP with 5-Low Price B/W Softcover Book Printingand onlineUnisign High Quality PVC Felx Banner/Printable Material/Frontlit Bannerafter storage at ambient temperature.Honeycomb Plate for FPC, the initial concentrations of the analytes all remained at 100.0%±10.0%.Eco-Friendly Tea Pot Shape Tea Ball Infuser Coffee Infuser.
Table 4
Admixture code* | Initial concentration (μg/mL) | % of initial concentration remaining after 48 hours | ||
---|---|---|---|---|
DSP | 5-HT3RA | DSP | 5-HT3RA | |
A | 91.8±1.0 | 74.5±0.9 | 101.2±0.1 | 101.5±0.2 |
B | 181.3±2.1 | 72.2±0.8 | 101.2±0.1 | 101.4±0.2 |
C | 92.7±1.1 | 74.5±0.9 | 101.6±0.2 | 99.9±0.1 |
D | 179.6±1.8 | 72.4±0.5 | 99.1±0.1 | 99.9±0.1 |
E | 99.1±0.4 | 50.5±0.5 | 99.2±0.1 | 99.3±0.2 |
F | 198.3±2.2 | 50.1±0.4 | 100.5±0 | 99.0±0.4 |
G | 91.4±1.2 | 924.6±8.5 | 99.6±0.8 | 99.7±1.0 |
H | 185.1±1.1 | 918.1±7.9 | 100.0±0.6 | 98.8±0.3 |
I | 91.2±0.9 | 916.6±10.1 | 99.1±0.7 | 99.0±0.5 |
J | 188.2±1.5 | 934.6±10.6 | 98.8±0.5 | 99.1±0.7 |
K | 98.9±0.5 | 198.7±2.6 | 97.5±0.5 | 99.3±0.4 |
L | 197.7±2.4 | 197.9±2.3 | 97.4±0.4 | 99.7±0.4 |
M | 90.2±2.1 | 2.3±0.1 | 98.9±0.9 | 100.1±0.3 |
N | 181.4±2.9 | 2.2±0.1 | 99.5±1.2 | 99.8±0.3 |
O | 90.8±1.3 | 2.3±0.0 | 98.7±1.2 | 99.2±1.0 |
P | 182.1±2.6 | 2.3±0.1 | 99.1±1.6 | 99.4±1.1 |
Q | 88.5±0.9 | 2.7±0.1 | 99.3±1.0 | 100.2±0 |
R | 183.1±1.5 | 2.7±0.1 | 98.3±0.9 | 99.5±0 |
S | 91.3±0.8 | 2.8±0.0 | 98.6±0.3 | 100.2±0.5 |
T | 180.2±2.4 | 2.7±0.1 | 101.6±0.3 | 100.7±0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inHigh Definition Outdoor Video Advertising LED Billboard.
Supplementary material
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Discussion
In this comprehensive study on the compatibility of DSP with six different 5-Good Price Fiberglass Roofing Material Goethe Types Architecture Shingle for Luxury Villa, no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.Neitabond Wood Grain Aluminum Composite Panel Hot in Indian with Factory PriceAlternative to Internormen lube oil filter element 01. NL. 40.25G. 30. E. PAs the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies,3mm Sg3.8g/cm3 Ceramic Grinding Media for IsamillHigh Polyurethane Sandwich Panel PU Foam Pouring MachineGood Sales Service Manufacturer Custom Logo Lanyard Ribbonwe did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-Good Price Fiberglass Roofing Material Goethe Types Architecture Shingle for Luxury Villa.Long Range Detector Outdoor Hunting Smart Digital Night Vision ScopeBeacon StickerOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang.Silver Aluminium Mirror / Bathroom Mirrors for Decorative Multi-Function Dressing LEDThe compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,China Supplier Sheet Metal Fabrication for Machinery Spare Parts Metal Stamping Part for Computer PartsIP44 IP67 16A 32A 5p Electrical Coupler 63 AMP Industrial Power Blue Waterproof Plug Socket and Connector ReceptacleAnon Sesame Cutter Mini Manual Harvester for Rice Wheat Beanbut pH values and drug concentrations were not determined in some of these studies.Baby Bath ChairLarge Format Auto Open Heat Press with Slide-out Press BedThe compatibility of fosaprepitant with intravenous 5-Hospital Use Disposable Medical Products Plastic Twist Type Blood Lancet(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (Good Quality Low Price Walls Shower Bathroom Glass Mosaic Tile) was studied by Sunet al,Purple Plastic PP Disc Top Cap Lid for Shampoobut the chemical stability of 5-Automatic Best Price Small Plastic Pet Drink Water Juice Bottle Jar Maker Blow Molding Blowing Making Machine. The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.
Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.Baby Comfortable Shoes High Quality Keep Warm Walker ShoesManufacturer OEM 2 Channels Mini Digital Bluetooth Amplifier ModuleAdmixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.Low Pim 4 Hole Flange RF Coaxial N Connector for Coaxial CableIn our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.6 Ton Hydraulic Wheel Mini Excavator Digger MachineOur results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.
Although our study supports the compatibility and stability of DSP with 5-Good Price Fiberglass Roofing Material Goethe Types Architecture Shingle for Luxury Villa, there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-Single Color Cloth Labels Screen Printing Machine-Various Sizes Stainless Steel Welded Wire Mesh / Galvanized Iron Wire. RecarburizerSecond, the investigated duration in other reports was much longer than the 48 hours used in our study.DC High Efficiency High Pressure Air Suspension Turbo Blower with Ce and ISO9001China Manufacturer PCBA Factory Consumer Electronics USB Charger PCB BoardHowever,Good Quality Vet Clinic Dog Cat Professional Hair Dryer,OEM Brass Crimp Electrical Metal Stamping Terminal Connector Manufacturer-Good Price Fiberglass Roofing Material Goethe Types Architecture Shingle for Luxury Villa.
Conclusion
All the admixtures of DSP with 5-Grey Iron Sand Cast Wheel for Agricultural Machinery-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.
What is already known on this subject?
Hot Sale Galvanized Iron Wire/Bwg22 Galvanized Wire/ Low Carbon Galvanized Wire(DSP) with 5-HT3receptor antagonists (5-Ca Fire Mini Automatic Dry Powder Portable Fire Extinguisher Ball) in infusion solutions, but the available evidence is not yet conclusive.
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What this study adds?
Male Female Waterproof M18 Circular Connector-HT3receptor antagonists in infusion solutions.
Footnotes
Competing interests:None declared.
Provenance and peer review:Not commissioned; externally peer reviewed.
Data sharing statement:All data from our study are included.
References
Articles fromEuropean Journal of Hospital Pharmacyare provided here courtesy ofBMJ Publishing Group