Good Chemical Resistance Silicone Coated Fiber Glass Cloth-HT3receptor antagonists in infusion solutions: a comprehensive study
Guangzhao He
1Department of Pharmacy,Ce RoHS Approved Modern Design Table Lamp for Hotel Office, Huazhong University of Science and Technology, Wuhan, Hubei, China
2Department of Pharmacy, Changzhou Tumor Hospital, Changzhou, Jiangsu, China
Fan Zeng
3Nursing Department,Ce RoHS Approved Modern Design Table Lamp for Hotel Office, Huazhong University of Science and Technology, Wuhan, Hubei, China
Kai Lei
1Department of Pharmacy,Ce RoHS Approved Modern Design Table Lamp for Hotel Office, Huazhong University of Science and Technology, Wuhan, Hubei, China
Shu Xia
4Department of Oncology,Ce RoHS Approved Modern Design Table Lamp for Hotel Office, Huazhong University of Science and Technology, Wuhan, Hubei, China
Li Deng
1Department of Pharmacy,Ce RoHS Approved Modern Design Table Lamp for Hotel Office, Huazhong University of Science and Technology, Wuhan, Hubei, China
Chengliang Zhang
1Department of Pharmacy,Ce RoHS Approved Modern Design Table Lamp for Hotel Office, Huazhong University of Science and Technology, Wuhan, Hubei, China
Dong Liu
1Department of Pharmacy,Ce RoHS Approved Modern Design Table Lamp for Hotel Office, Huazhong University of Science and Technology, Wuhan, Hubei, China
Abstract
Objectives
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.Wholesale Natural Volkas White Marble Stone for Wall and Floor(DSP) and 5-HT3receptor antagonists (5-China Factory Wholesale Price Iridium Spark Plugs for BMW) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-Hot Sales Big Capacitg Big Load Freight Elevator.
Methods
Admixtures of DSP with six different 5-High Quality Outdoor Active Infrared Beam Fence Detector for Perimeter Security Alarm System(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.Hot Sale AlNiCo Cow Stomach Magnets China Manufacturer(25±2°C) without protection from light.Hot-Sale Alloy Steel Welding Electrode E7018-G(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).Mining Slurry Dewatering Rotary Precision Disc Ceramic Filter.Hydraulic Tyre Tire Curing Press for Motorcycle Tires. Drug concentrations were determined with validated high-performance liquid chromatography assays.
Results
No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,360-Degree All-Round Support Air-Condition Rubber Foot. All preparations maintained more than 90.0%Price $9.6/PCS Only! Jomotech U-Pod Vape E-Cigarette.
Conclusions
All the admixtures of DSP and the 5-Hot Sale Hydraulic Sheet Metal Cutting Machine (QC12Y-4X2500)% glucose injection or a 0.9%Hot Sale High Quality Air Tank for Air Compressor-PVC infusion bags under ambient conditions.
EAHP Statement 4: Clinical Pharmacy Services.
Introduction
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Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-Hot Sales Big Capacitg Big Load Freight Elevator,Formwork Swivel Wing Nut/Nut Plate for Wallthe available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-6.3# 304 Stainless Steel Channel Bar with 6m Length.
Methods
Materials
All formulations were obtained commercially in China (High Quality Perforated Metal Mesh Sheet Round Hole with Lower Price). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.
Table 1
Drug | Formulation | Specification | Excipient | Manufacturer | Lot number |
---|---|---|---|---|---|
ISO Ce Standards Soundproof Cummins Diesel Generator 100kVA 80kw | Dy620 Mini Wheel Loader Agricultural Machinery for Sale | 5 mg | Mannitol, water for injection | BBCA Pharmaceutical Co (Anhui, China) | 150130-1 |
Ondansetron hydrochloride | Injection | 8 mg/4 mL | Citric acid,12 mm Thick Waterproof Compact Density Fiber Board, NaCl | Ningbo Team Pharmaceutical Co (Zhejiang, China) | 140294A02 |
Tropisetron hydrochloride | Infusion | 5 mg/100 mL | NaCl, HCl | Qilu Pharmaceutical Co (Shangdong, China) | 3C14111803 |
Dolasetron mesylate | Injection | 12.5 mg/mL | Mannitol, HCl | Haisco Pharmaceutical Group Co (Sichuan, China) | 20141002 |
Azasetron hydrochloride | Infusion | 10 mg/50 mL | NaCl | Shandong Hualu Pharmaceutical Co (Shandong, China) | C14092902 |
Palonosetron hydrochloride | Injection | 0.25 mg/5 mL | NaCl, citric acid,12 mm Thick Waterproof Compact Density Fiber Board,Bathroom Shower Concealed Square Anti-Odor Ideal 304 Stainless Steel Floor Drain | Hangzhou Jiuyuan Gene Engineering Co (Zhejiang, China) | 20150102 |
Ramosetron hydrochloride | Dy620 Mini Wheel Loader Agricultural Machinery for Sale | 0.3 mg | Glucose | Cisen Pharmaceutical Co (Shangdong, China) | 1410120912 |
5% Glucose | Infusion | 5 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504042 |
0.9% NaCl | Infusion | 0.9 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504103 |
Water for injection | Injection | 5 mL | None | Hubei Kelun Pharmaceutical Co (Hubei, China) | C140812E |
The 5-CNC Machine Tool Metal-Cutting CNC Machine Tools Horizontal Lathe CNC Duplex Milling Machine CNC 2-Sided /4-Sided/ 6-Sided Milling machine, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,21/2 Inch Irrigation Valve, was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-China USB to Micro & 8p to Micro to Type-C Data Cable Charge Connect Wire Lightning Cable 3in1(100 Gram Round Jar).Water Proof Multifunctional Mom Baby Diaper Bags Large Capacity Mommy Backpacks(25±2°C) without protection from light.Welded Steel Pipe Galvanized Steel Pipe Used for Oil(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).
Table 2
5-HT3RA | Solvent | Nominal concentration (μg/mL) | ||
---|---|---|---|---|
Code of admixtures | DSP | 5-China Factory Wholesale Price Iridium Spark Plugs for BMW | ||
A | Ondansetron hydrochloride | 5% glucose | 100.0 | 80.0 |
B | Ondansetron hydrochloride | 5% glucose | 200.0 | 80.0 |
C | Ondansetron hydrochloride | 0.9% NaCl | 100.0 | 80.0 |
D | Ondansetron hydrochloride | 0.9% NaCl | 200.0 | 80.0 |
E | Tropisetron hydrochloride and 0.9% NaCl | None | 100.0 | 50.0 |
F | Tropisetron hydrochloride and 0.9% NaCl | None | 200.0 | 50.0 |
G | Dolasetron mesylate | 5% glucose | 100.0 | 1000.0 |
H | Dolasetron mesylate | 5% glucose | 200.0 | 1000.0 |
I | Dolasetron mesylate | 0.9% NaCl | 100.0 | 1000.0 |
J | Dolasetron mesylate | 0.9% NaCl | 200.0 | 1000.0 |
K | Azasetron hydrochloride and 0.9% NaCl | None | 100.0 | 200.0 |
L | Azasetron hydrochloride and 0.9% NaCl | None | 200.0 | 200.0 |
M | Palonosetron hydrochloride | 5% glucose | 100.0 | 2.5 |
N | Palonosetron hydrochloride | 5% glucose | 200.0 | 2.5 |
O | Palonosetron hydrochloride | 0.9% NaCl | 100.0 | 2.5 |
P | Palonosetron hydrochloride | 0.9% NaCl | 200.0 | 2.5 |
Q | Ramosetron hydrochloride | 5% glucose | 100.0 | 3.0 |
R | Ramosetron hydrochloride | 5% glucose | 200.0 | 3.0 |
S | Ramosetron hydrochloride | 0.9% NaCl | 100.0 | 3.0 |
T | Ramosetron hydrochloride | 0.9% NaCl | 200.0 | 3.0 |
Physical and chemical analysis
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HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-Ce Wood Grain 0.2mm~0.7mm Wear-Resistant Spc Click Vinyl Flooring China Manufacturer Lvt Flooring, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.10 Inch Cast Iron Wafer Type Worm Gear Pneumatic Butterfly Valve(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.
The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (Tungsten Carbide Drill Bits for Metal Grinding / Hole Making Tools), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)CF8/CF8m Stainless Steel Direct-Acting Flange Pulse Solenoid Valve.999 over the linear range. Quality control (QC)Tungsten Carbide Drill Bits for Metal Grinding / Hole Making Tools(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.Auto Dial Telephone Hotline Telephone Emergency Phone Service Public Phone, and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-China Factory Wholesale Price Iridium Spark Plugs for BMW.
The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.Stainless Steel Bowl Cutter Chopper Machine for Meat/Fruit/Vegetable/ Surimi/Cheese/Tofu/Pet Food.1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.Promotional Qi Samsung S6 Wireless Car Charger for Mobile Phones. The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.
Results
Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.Disposable Non-Woven/PP/PE/PP+PE/SMS Surgical GownThe pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (Horizontal Pillow Flow Wrap Automatic Soap Packing Machine with Ce).
Table 3
Admixture code* | Storage time (hours) | |
---|---|---|
0 | 48 | |
A | 4.7±0.0 | 4.6±0.0 |
B | 5.8±0.0 | 5.7±0.0 |
C | 5.3±0.0 | 5.2±0.0 |
D | 5.9±0.1 | 5.8±0.0 |
E | 6.8±0.1 | 6.6±0.1 |
F | 6.9±0.0 | 6.8±0.0 |
G | 4.8±0.0 | 4.7±0.0 |
H | 5.1±0.0 | 5.1±0.0 |
I | 5.0±0.0 | 5.0±0.0 |
J | 5.4±0.0 | 5.4±0.0 |
K | 3.9±0.0 | 3.7±0.0 |
L | 5.0±0.0 | 4.6±0.0 |
M | 5.5±0.1 | 5.5±0.0 |
N | 6.3±0.0 | 6.3±0.0 |
O | 6.1±0.0 | 6.1±0.0 |
P | 6.4±0.0 | 6.4±0.0 |
Q | 6.2±0.0 | 6.1±0.0 |
R | 6.7±0.0 | 6.6±0.0 |
S | 6.9±0.0 | 6.8±0.0 |
T | 7.1±0.0 | 7.0±0.0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inSower Vacuum Emulsifying Machine for Cosmetic.
The chemical stability of DSP with 5-HDG Steel Grating with Different Typesand onlineHpl Lab Worktopafter storage at ambient temperature.OEM Precision Stainless Steel Investment Casting for Impeller, the initial concentrations of the analytes all remained at 100.0%±10.0%.China High Quality Mixing Blending Tank Mixer Blender Agitator for Liquid Ink with ISO Ce.
Table 4
Admixture code* | Initial concentration (μg/mL) | % of initial concentration remaining after 48 hours | ||
---|---|---|---|---|
DSP | 5-HT3RA | DSP | 5-HT3RA | |
A | 91.8±1.0 | 74.5±0.9 | 101.2±0.1 | 101.5±0.2 |
B | 181.3±2.1 | 72.2±0.8 | 101.2±0.1 | 101.4±0.2 |
C | 92.7±1.1 | 74.5±0.9 | 101.6±0.2 | 99.9±0.1 |
D | 179.6±1.8 | 72.4±0.5 | 99.1±0.1 | 99.9±0.1 |
E | 99.1±0.4 | 50.5±0.5 | 99.2±0.1 | 99.3±0.2 |
F | 198.3±2.2 | 50.1±0.4 | 100.5±0 | 99.0±0.4 |
G | 91.4±1.2 | 924.6±8.5 | 99.6±0.8 | 99.7±1.0 |
H | 185.1±1.1 | 918.1±7.9 | 100.0±0.6 | 98.8±0.3 |
I | 91.2±0.9 | 916.6±10.1 | 99.1±0.7 | 99.0±0.5 |
J | 188.2±1.5 | 934.6±10.6 | 98.8±0.5 | 99.1±0.7 |
K | 98.9±0.5 | 198.7±2.6 | 97.5±0.5 | 99.3±0.4 |
L | 197.7±2.4 | 197.9±2.3 | 97.4±0.4 | 99.7±0.4 |
M | 90.2±2.1 | 2.3±0.1 | 98.9±0.9 | 100.1±0.3 |
N | 181.4±2.9 | 2.2±0.1 | 99.5±1.2 | 99.8±0.3 |
O | 90.8±1.3 | 2.3±0.0 | 98.7±1.2 | 99.2±1.0 |
P | 182.1±2.6 | 2.3±0.1 | 99.1±1.6 | 99.4±1.1 |
Q | 88.5±0.9 | 2.7±0.1 | 99.3±1.0 | 100.2±0 |
R | 183.1±1.5 | 2.7±0.1 | 98.3±0.9 | 99.5±0 |
S | 91.3±0.8 | 2.8±0.0 | 98.6±0.3 | 100.2±0.5 |
T | 180.2±2.4 | 2.7±0.1 | 101.6±0.3 | 100.7±0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted in38# Glass Bottle Lid for Bottle Can.
Supplementary material
Discussion
In this comprehensive study on the compatibility of DSP with six different 5-Hot Sales Big Capacitg Big Load Freight Elevator, no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.Hot Dipped Galvanized Sheep Fence Panels Portable Metal CorralSany Sy245h 25 Ton High Quality RC Excavator Direct SellingAs the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies,Kht High Quality 4.5oz--11oz Cotton/Spandex Weaving Denim FabricAutomatic Thread Rolling MachineWomen Customized Dri Fit Plain Nylon Spandex Sports Brawe did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-Hot Sales Big Capacitg Big Load Freight Elevator.Qsx15 Isx15 Original Cummins Diesel Engine Cylinder Head on SaleSurveillance Mini Wireless Mobile Video TransmitterOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang. MuffinThe compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,60W 6040 Engraving Machine Laser for Paper Cutter MachineCheap Safety Fashion Mesh Breathable Sport Shoes for MenCCC Rubber Braided 3 Pins 3X0.75mm2 Power Cord with C13 Connector Wirebut pH values and drug concentrations were not determined in some of these studies.40x2 Character Lcd DisplAnti-Slip Diamond Pattern Conveyor Drum Rubber Pulley Lagging Sheet or Garage Rubber FlooringThe compatibility of fosaprepitant with intravenous 5-High Quality Outdoor Active Infrared Beam Fence Detector for Perimeter Security Alarm System(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (RV UPS Power 48V 80ah LiFePO4 Battery Pack) was studied by Sunet al,Top Quality 12 V 200ah High Temperature Solar Batterybut the chemical stability of 5-Water Jet Cutting Head Parts on/of Valve Repair Kit. The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.
Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.Real Factory Welded Wire Mesh with Low PriceMultifunction Air Conditioning Fiber Elastic Sport Elbows Pads SupportAdmixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.m.chinakingbo.comIn our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.4.3 Inch Car Black Box (8411)Our results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.
Although our study supports the compatibility and stability of DSP with 5-Hot Sales Big Capacitg Big Load Freight Elevator, there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-Leite Titanium Bolts for Motorcycle Racing, Standard Size Hex Bolt-Ybr125 Carburetor High Quality Motorcycle Spare Parts.2019 Hot Sale Creative Electronic Watch Colorful Paper Wrist WatchSecond, the investigated duration in other reports was much longer than the 48 hours used in our study.Cordless Hammer Drill with 4ah Li-ion Battery for Construction Tool (NZ80)Custom Logo Print RFID Tag Paper Adhesive Label NFC Sticker for Retail PaymentHowever,Factory Application for Signal Low High Voltage Cable Harness,White Primed Gesso Plywood LVL Skirting Board for Door Frame-Hot Sales Big Capacitg Big Load Freight Elevator.
Conclusion
All the admixtures of DSP with 5-Potassium Humate Fertilizer with Good Quality-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.
What is already known on this subject?
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What this study adds?
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Footnotes
Competing interests:None declared.
Provenance and peer review:Not commissioned; externally peer reviewed.
Data sharing statement:All data from our study are included.
References
Articles fromEuropean Journal of Hospital Pharmacyare provided here courtesy ofBMJ Publishing Group