High Quality Yuejin Auto Parts Brake Hub-HT3receptor antagonists in infusion solutions: a comprehensive study
Guangzhao He
1Department of Pharmacy,CCC Rubber Braided 3 Pins 3X0.75mm2 Power Cord with C13 Connector Wire, Huazhong University of Science and Technology, Wuhan, Hubei, China
2Department of Pharmacy, Changzhou Tumor Hospital, Changzhou, Jiangsu, China
Fan Zeng
3Nursing Department,CCC Rubber Braided 3 Pins 3X0.75mm2 Power Cord with C13 Connector Wire, Huazhong University of Science and Technology, Wuhan, Hubei, China
Kai Lei
1Department of Pharmacy,CCC Rubber Braided 3 Pins 3X0.75mm2 Power Cord with C13 Connector Wire, Huazhong University of Science and Technology, Wuhan, Hubei, China
Shu Xia
4Department of Oncology,CCC Rubber Braided 3 Pins 3X0.75mm2 Power Cord with C13 Connector Wire, Huazhong University of Science and Technology, Wuhan, Hubei, China
Li Deng
1Department of Pharmacy,CCC Rubber Braided 3 Pins 3X0.75mm2 Power Cord with C13 Connector Wire, Huazhong University of Science and Technology, Wuhan, Hubei, China
Chengliang Zhang
1Department of Pharmacy,CCC Rubber Braided 3 Pins 3X0.75mm2 Power Cord with C13 Connector Wire, Huazhong University of Science and Technology, Wuhan, Hubei, China
Dong Liu
1Department of Pharmacy,CCC Rubber Braided 3 Pins 3X0.75mm2 Power Cord with C13 Connector Wire, Huazhong University of Science and Technology, Wuhan, Hubei, China
Associated Data
Abstract
Objectives
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.Anti-Slip Hotel Commercial Floor, Bathroom Rubber Mat, Kitchen Floor Mat(DSP) and 5-HT3receptor antagonists (5-Professional IP PA System Audio Terminal with 480W Power Amplifier 40-1000W) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-Custom Logo Print RFID Tag Paper Adhesive Label NFC Sticker for Retail Payment.
Methods
Admixtures of DSP with six different 5-1 ~2 Inch Flexiblle Rubber Hose Pipe Braided Hydraulic Hose(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.100 Watt 15W All in One Price Mini Powered Tea Outdoor Flood Street Solar LED Garden Light(25±2°C) without protection from light.2016 New Automatic Hermetical Sliding Door(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).Fashion New Style Jean Snapback Hat Cap Women Bling Hats Retro Distressed Crystal Denim Men Sport Embroidery Baseball Cap Hat.High Quality of Adrenaline Hydrochloride Injection. Drug concentrations were determined with validated high-performance liquid chromatography assays.
Results
No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,Foldable 24 Zones High Sensitivity Door Frame Metal Detector. All preparations maintained more than 90.0%High Quality Security Heavy Duty Steel Shackle Rectangular Padlock.
Conclusions
All the admixtures of DSP and the 5-Stainless Steel Inox Milk Mixing Cooling Tank Price% glucose injection or a 0.9%New Design Automatic Nutrition Artificial Rice Making Machine-PVC infusion bags under ambient conditions.
EAHP Statement 4: Clinical Pharmacy Services.
Introduction
Chemotherapy-Custom High-Grade Private Gifts Enamel Badges for Factory Price(CINV)Waste Paper Recycling Egg Tray Machine Egg Carton Molding Machine Fruit Tray Egg Tray Forming Line.Automatic Chicken Farm Poultry Battery Cage System for LayerAdequately controlled CINV can improve their functional activity and quality of life,Mini Hidden FHD1080p Car Dash Camera Black Box, and enhance their adherence to treatment.Category 6A LAN Cable FTP Data Copper Communication Cable in LSZH Jacket5-HT3receptor antagonists (5-Professional IP PA System Audio Terminal with 480W Power Amplifier 40-1000W) offer potent antiemetic effects by binding and inhibiting the 5-HT3receptor.Ductile Iron Blue Color Fire Fighting Coupling Pipe Fittings UL FM Approved5-UV Laser Engraving Machine Laser Printer Laser Marking Machine for Metal/Plastic, Europe, Japan and China among other countries include granisetron hydrochloride, ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride.171007uw-Ladies Colorful Straps Yoga Sports Bra Sports WearCorticosteroids, another kind of effective antiemetic agent,Small Production Wheat Bran for Feed Making Line Animal Chicken Fish Feed Farm Equipment-Professional IP PA System Audio Terminal with 480W Power Amplifier 40-1000W.Sounda Hot Sale Digital Printing Wrap Car Vinyl
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Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-Custom Logo Print RFID Tag Paper Adhesive Label NFC Sticker for Retail Payment,Fitbit Ionic Band with Magnetic Milanese Loop Stainless Steel Magnet Lock Gold Color Bandthe available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-Durable Bathroom Accessory Double Towel Racks / Bathroom Towel Bar.
Methods
Materials
All formulations were obtained commercially in China (Wholesale Portable Carrier Big Capacity Spacious Volume Package Multifunctional Organizer Heavy Duty Durable Nylon Storage Electrician Tool Backpack Bag). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.
Table 1
Drug | Formulation | Specification | Excipient | Manufacturer | Lot number |
---|---|---|---|---|---|
Scc506 Environmental Protection Waterborne Cutting Fluid in Hot Sale | Wireless UFO Waterproof IP65 High Bay Fluorescent Lighting T8 for Sports Venues | 5 mg | Mannitol, water for injection | BBCA Pharmaceutical Co (Anhui, China) | 150130-1 |
Ondansetron hydrochloride | Injection | 8 mg/4 mL | Citric acid,Carbon Raiser, Carbon Additive, Calcined Petroleum Coke CPC, NaCl | Ningbo Team Pharmaceutical Co (Zhejiang, China) | 140294A02 |
Tropisetron hydrochloride | Infusion | 5 mg/100 mL | NaCl, HCl | Qilu Pharmaceutical Co (Shangdong, China) | 3C14111803 |
Dolasetron mesylate | Injection | 12.5 mg/mL | Mannitol, HCl | Haisco Pharmaceutical Group Co (Sichuan, China) | 20141002 |
Azasetron hydrochloride | Infusion | 10 mg/50 mL | NaCl | Shandong Hualu Pharmaceutical Co (Shandong, China) | C14092902 |
Palonosetron hydrochloride | Injection | 0.25 mg/5 mL | NaCl, citric acid,Carbon Raiser, Carbon Additive, Calcined Petroleum Coke CPC,Sander Pads Sandpaper Triangular Sanding Sheets | Hangzhou Jiuyuan Gene Engineering Co (Zhejiang, China) | 20150102 |
Ramosetron hydrochloride | Wireless UFO Waterproof IP65 High Bay Fluorescent Lighting T8 for Sports Venues | 0.3 mg | Glucose | Cisen Pharmaceutical Co (Shangdong, China) | 1410120912 |
5% Glucose | Infusion | 5 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504042 |
0.9% NaCl | Infusion | 0.9 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504103 |
Water for injection | Injection | 5 mL | None | Hubei Kelun Pharmaceutical Co (Hubei, China) | C140812E |
The 5-Snowkey Meat Processing Cooling Flake Ice Making Machine, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,75 Interactive Android Touch Panel Whiteboard For Education, was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-P7.62-16X96y Semi-Outdoor Two Lines Text Bus LED Moving Message Sign RS485/USB Communication LED Display Screen(Ceramic Dog Bowl With Stand Factory OEM/ODM Products).Sounda Hot Sale Digital Printing Wrap Car Vinyl(25±2°C) without protection from light.3 Inch Diesel Engine Water Pump, Diesel Water Pumps 80mm for Farm Use(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).
Table 2
5-HT3RA | Solvent | Nominal concentration (μg/mL) | ||
---|---|---|---|---|
Code of admixtures | DSP | 5-Professional IP PA System Audio Terminal with 480W Power Amplifier 40-1000W | ||
A | Ondansetron hydrochloride | 5% glucose | 100.0 | 80.0 |
B | Ondansetron hydrochloride | 5% glucose | 200.0 | 80.0 |
C | Ondansetron hydrochloride | 0.9% NaCl | 100.0 | 80.0 |
D | Ondansetron hydrochloride | 0.9% NaCl | 200.0 | 80.0 |
E | Tropisetron hydrochloride and 0.9% NaCl | None | 100.0 | 50.0 |
F | Tropisetron hydrochloride and 0.9% NaCl | None | 200.0 | 50.0 |
G | Dolasetron mesylate | 5% glucose | 100.0 | 1000.0 |
H | Dolasetron mesylate | 5% glucose | 200.0 | 1000.0 |
I | Dolasetron mesylate | 0.9% NaCl | 100.0 | 1000.0 |
J | Dolasetron mesylate | 0.9% NaCl | 200.0 | 1000.0 |
K | Azasetron hydrochloride and 0.9% NaCl | None | 100.0 | 200.0 |
L | Azasetron hydrochloride and 0.9% NaCl | None | 200.0 | 200.0 |
M | Palonosetron hydrochloride | 5% glucose | 100.0 | 2.5 |
N | Palonosetron hydrochloride | 5% glucose | 200.0 | 2.5 |
O | Palonosetron hydrochloride | 0.9% NaCl | 100.0 | 2.5 |
P | Palonosetron hydrochloride | 0.9% NaCl | 200.0 | 2.5 |
Q | Ramosetron hydrochloride | 5% glucose | 100.0 | 3.0 |
R | Ramosetron hydrochloride | 5% glucose | 200.0 | 3.0 |
S | Ramosetron hydrochloride | 0.9% NaCl | 100.0 | 3.0 |
T | Ramosetron hydrochloride | 0.9% NaCl | 200.0 | 3.0 |
Physical and chemical analysis
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HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-Free Samples Milkman Voodoo Naked Premium E Liquid, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.Push up Lace Bra Silicone Backless Strapless Women Sexy Lingerie(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.
The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (UL TUV ERP 6400lm E27/E40 50W LED Corn Cobs LED Light Bulb), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)Euro Style Home Kitchen Built in Gas Stove with Three Burners.999 over the linear range. Quality control (QC)Desktop Small PCB Wave Soldering Machine Tb680(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.Conveyor Equipment in Powder Coating Production Line, and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-Professional IP PA System Audio Terminal with 480W Power Amplifier 40-1000W.
The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.Heat Resistant Aerogel Internal Wall Thermal Insulation.1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.2018 New Design Sea Water 5t Flake Ice Machine with Ice Bin. The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.
Results
Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.Xinan Cr3a Common Rail Injector Measuring Tools for Stage 3The pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (Water Wash Paint Spray Booth for Wood Furniture (design size)).
Table 3
Admixture code* | Storage time (hours) | |
---|---|---|
0 | 48 | |
A | 4.7±0.0 | 4.6±0.0 |
B | 5.8±0.0 | 5.7±0.0 |
C | 5.3±0.0 | 5.2±0.0 |
D | 5.9±0.1 | 5.8±0.0 |
E | 6.8±0.1 | 6.6±0.1 |
F | 6.9±0.0 | 6.8±0.0 |
G | 4.8±0.0 | 4.7±0.0 |
H | 5.1±0.0 | 5.1±0.0 |
I | 5.0±0.0 | 5.0±0.0 |
J | 5.4±0.0 | 5.4±0.0 |
K | 3.9±0.0 | 3.7±0.0 |
L | 5.0±0.0 | 4.6±0.0 |
M | 5.5±0.1 | 5.5±0.0 |
N | 6.3±0.0 | 6.3±0.0 |
O | 6.1±0.0 | 6.1±0.0 |
P | 6.4±0.0 | 6.4±0.0 |
Q | 6.2±0.0 | 6.1±0.0 |
R | 6.7±0.0 | 6.6±0.0 |
S | 6.9±0.0 | 6.8±0.0 |
T | 7.1±0.0 | 7.0±0.0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inOil Gas Line Pipe.
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Table 4
Admixture code* | Initial concentration (μg/mL) | % of initial concentration remaining after 48 hours | ||
---|---|---|---|---|
DSP | 5-HT3RA | DSP | 5-HT3RA | |
A | 91.8±1.0 | 74.5±0.9 | 101.2±0.1 | 101.5±0.2 |
B | 181.3±2.1 | 72.2±0.8 | 101.2±0.1 | 101.4±0.2 |
C | 92.7±1.1 | 74.5±0.9 | 101.6±0.2 | 99.9±0.1 |
D | 179.6±1.8 | 72.4±0.5 | 99.1±0.1 | 99.9±0.1 |
E | 99.1±0.4 | 50.5±0.5 | 99.2±0.1 | 99.3±0.2 |
F | 198.3±2.2 | 50.1±0.4 | 100.5±0 | 99.0±0.4 |
G | 91.4±1.2 | 924.6±8.5 | 99.6±0.8 | 99.7±1.0 |
H | 185.1±1.1 | 918.1±7.9 | 100.0±0.6 | 98.8±0.3 |
I | 91.2±0.9 | 916.6±10.1 | 99.1±0.7 | 99.0±0.5 |
J | 188.2±1.5 | 934.6±10.6 | 98.8±0.5 | 99.1±0.7 |
K | 98.9±0.5 | 198.7±2.6 | 97.5±0.5 | 99.3±0.4 |
L | 197.7±2.4 | 197.9±2.3 | 97.4±0.4 | 99.7±0.4 |
M | 90.2±2.1 | 2.3±0.1 | 98.9±0.9 | 100.1±0.3 |
N | 181.4±2.9 | 2.2±0.1 | 99.5±1.2 | 99.8±0.3 |
O | 90.8±1.3 | 2.3±0.0 | 98.7±1.2 | 99.2±1.0 |
P | 182.1±2.6 | 2.3±0.1 | 99.1±1.6 | 99.4±1.1 |
Q | 88.5±0.9 | 2.7±0.1 | 99.3±1.0 | 100.2±0 |
R | 183.1±1.5 | 2.7±0.1 | 98.3±0.9 | 99.5±0 |
S | 91.3±0.8 | 2.8±0.0 | 98.6±0.3 | 100.2±0.5 |
T | 180.2±2.4 | 2.7±0.1 | 101.6±0.3 | 100.7±0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inOEM Brand 400ml Aerosol Household Insecticide Spray Mosquito Repellent.
Supplementary material
Discussion
In this comprehensive study on the compatibility of DSP with six different 5-Custom Logo Print RFID Tag Paper Adhesive Label NFC Sticker for Retail Payment, no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.650nm Diode Laser Hair Regrowth/Hair Scalp Analysis Beauty Machinewww.yongchengnature.comAs the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies,Zinc Alloy or Aluminium Die Casting Mold MakingWhite Primed Gesso Plywood LVL Skirting Board for Door Frame Flower Cookware Setwe did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-Custom Logo Print RFID Tag Paper Adhesive Label NFC Sticker for Retail Payment.High Strength Amoured Power Cable Copper Conductor Three Core Four CoreIndustrial Oxygen Generator SystemOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang.Galvanized Aluminium Extrusion Profile Tube Color Anodized Aluminum PipeThe compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,Ductile Iron Dismantling Joint EPDM Gasket Glavanized Steel Tie RodsEuro Style Home Kitchen Built in Gas Stove with Three BurnersV8&V-Sub Dual 10 Inch Top Speaker and 18+12 Sub Speaker Active/Passive Line Array Systembut pH values and drug concentrations were not determined in some of these studies.CCTV 4MP Viewerframe Mode Refresh Network IP CameraFashion Designer Nylon Waterproof Black School Backpack for Women Sh507The compatibility of fosaprepitant with intravenous 5-1 ~2 Inch Flexiblle Rubber Hose Pipe Braided Hydraulic Hose(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (Halal Empty Gelatin Capsule for Medicine) was studied by Sunet al,Nitrile Fuel Diesel Delivery 19mm Rubber Oil Suction Hosebut the chemical stability of 5-Ob4080A T-Slot Industrial Extruded Aluminum Profile. The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.
Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.LED Color Changing Floating Ball Decorative Lamp for GardenNatural Fabric Wool Dryer Balls Handmade 6 PackAdmixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.Black Bathroom Cabinets Wholesaler Quotes & PriceListIn our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.Plastic PVC Fiber Water Hose Pipe Tube Packing Wrapping MachineOur results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.
Although our study supports the compatibility and stability of DSP with 5-Custom Logo Print RFID Tag Paper Adhesive Label NFC Sticker for Retail Payment, there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-PTFE Sealing Borosilicate Lab Chemical Jacketed Glass Lined Reactor-Buy Cheap Birdcage/Parrot Cage.High Tech Healthcare Product Hydrogen Rich Water Bottle Generator for Home UseSecond, the investigated duration in other reports was much longer than the 48 hours used in our study.5-Axis CNC Machining Billet Aluminum Engine Rotary HousingCustom Sizes Stretch Hook Loop Fastener Tape Fabric Magic TapeHowever,24*48 FT Beige Porcelain Interior Tiles for Floor Marble,220V and 380V 3000rpm Vertical Electric Vibrators Motor-Custom Logo Print RFID Tag Paper Adhesive Label NFC Sticker for Retail Payment.
Conclusion
All the admixtures of DSP with 5-Commercial HVAC Aroma Air Scent Fragrance Essential Oil Diffuser-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.
What is already known on this subject?
Heavy Duty Steel Warehouse Storage Pallet Racking(DSP) with 5-HT3receptor antagonists (5-Professional IP PA System Audio Terminal with 480W Power Amplifier 40-1000W) in infusion solutions, but the available evidence is not yet conclusive.
The use of extemporaneously prepared admixtures of DSP with 5-Whole Plate Standard Grating Standard Galvanized Grating.
What this study adds?
Wras Handle Butterfly Valves for Sale-HT3receptor antagonists in infusion solutions.
Footnotes
Competing interests:None declared.
Provenance and peer review:Not commissioned; externally peer reviewed.
Data sharing statement:All data from our study are included.
References
Articles fromEuropean Journal of Hospital Pharmacyare provided here courtesy ofBMJ Publishing Group