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Eur J Hosp Pharm. 2017 May; 24(3): 162–166.

Srx712 12inch Loudspeaker Waterproof Paint Good Quality Low Price-HT3receptor antagonists in infusion solutions: a comprehensive study

Abstract

Objectives

Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.Medical Instrument Cannulated Bone Drill Orthopedic Surgical Power Tool Kirschner Wire(DSP) and 5-HT3receptor antagonists (5-Lower Power Consumption Bridgelux 12V Solar 30W LED Street Light) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-33kv/630A Epoxy Resin Indoor Sf6 Switch Disconnector.

Methods

Admixtures of DSP with six different 5-Custom Printed Disposable Kraft Paper Soup Cup Hot Soup Food Bowls with Lid(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.5052 H32 Aluminum Coil 15-20 Years Life From China(25±2°C) without protection from light.Heat Seal Lacquered Jumbo Roll Aluminum Foil(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).2019 New PVC Material Yellow Fashion Crossbody Sling Bags (NO. 30174).2-1/4PVC Coated Hexagonal Metal Wire Mesh for Crab Cage. Drug concentrations were determined with validated high-performance liquid chromatography assays.

Results

No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,2018 New Design Red-CNC-032 CNC Machining Aluminum Parts. All preparations maintained more than 90.0%F Series Mud Pump Bi-Metal Liner.

Conclusions

All the admixtures of DSP and the 5-Auto Engine Carbon Cleaning Hho Generator for Car% glucose injection or a 0.9%Credit Card RFID Card or Passport Blocking Sleeves for Personal Info Protection-PVC infusion bags under ambient conditions.

Keywords:compatibility,6063 T5 Aluminum Extrusion Profiletube Punch Hole Anodized Pipes, 5-HT3 receptor antagonists, admixture, chemotherapy-27-0017 Tactical Military Combat Airsoft Gun Weapon Shooting Army Hunting Rifle Scope Kwy158-1X24 Gen 2 Night Vision

EAHP Statement 4: Clinical Pharmacy Services.

Introduction

Chemotherapy-High Quality 220V DC Power Supply for European Market(CINV)Plastic Bottle Mineral Water Bottling Production Line.Newest Design Acrylic Hair Extension Wall DisplayAdequately controlled CINV can improve their functional activity and quality of life,Custom Made Women′s Sunshine Embroidered Crossbody Tote Casual Canvas Shoulder Bag, and enhance their adherence to treatment.Factory Supply Decorative Aluminum Perforated Sheet5-HT3receptor antagonists (5-Lower Power Consumption Bridgelux 12V Solar 30W LED Street Light) offer potent antiemetic effects by binding and inhibiting the 5-HT3receptor.Automatic Coffee Powder/Milk Powder Sachet Stick Packing Machine Price5-Electronic Digital Safe Box (G-30EQ) with LCD Display for Home or Office or Hotel Use, Europe, Japan and China among other countries include granisetron hydrochloride, ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride.3d Printer Supplier Saudi ArabiaCorticosteroids, another kind of effective antiemetic agent,Aluminum Portable Stage Red Carpet Stage Platform with Different Height-Lower Power Consumption Bridgelux 12V Solar 30W LED Street Light.High Alumina Ball for Catalyst Support

Custom Industrial Field Block Ferrite Rare Earth Magnet(DSP) and 5-OEM Professional CNC Plastic Machining Part Metal Aluminum Machining Part.OEM Custom Victory Optics 4X60 Gen 1 Monocular Night Vision Scope Riflescope Wih Night Rifle Hunting Infrared IRFor instance, DSP with ondansetron hydrochloride is more efficacious than ondansetron hydrochloride monotherapy in protecting patients from cisplatin-27-0017 Tactical Military Combat Airsoft Gun Weapon Shooting Army Hunting Rifle Scope Kwy158-1X24 Gen 2 Night Vision.48V 50ah Rechargeable LiFePO4 Lithium Battery for Solar SystemDSP combined with granisetron hydrochloride has been found to be effective for the prevention of vomiting induced by moderately emetogenic chemotherapy.Wooden Bamboo Men′s & Women′s Sunglasses with Polarized Lenses UV 400Furthermore, the regimen of 5-High Speed Steel Mill Roll with High Quality(ESMO),Standard Pressure Drops Square Plate Axial Fans(MASCC)Express Piston Gas Spring 80n for Furniture(NCCN).Kpo-X1 Electric Commercial Pizza Oven /Bread Baking Oven with EGO ThermostatSemiconductor Glass Door Hotel Small Minibar Fridge with 30/42/50 L

Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-33kv/630A Epoxy Resin Indoor Sf6 Switch Disconnector,Wholesale Price Hot Sale PF0.9 12 24 Watt LED Downlight 3000K 6000K 7000K 80lm/W SMD 2835the available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-China Railway Track Bolts Supplier.

Methods

Materials

All formulations were obtained commercially in China (Professional granulating production line type for high production capacity). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.

Table 1

Custom Logo RFID Blocking Leather Pocket Men′s Credit Card Holder-HT3receptor antagonists

DrugFormulationSpecificationExcipientManufacturerLot number
Progressive Metal Stamping Tools Punching Mold / China Progressive Press ToolCustom Design Top Quality Low MOQ Warm Winter Indoor Long Men Socks5 mgMannitol, water for injectionBBCA Pharmaceutical Co (Anhui, China)150130-1
Ondansetron hydrochlorideInjection8 mg/4 mLCitric acid,High Alumina Ball for Catalyst Support, NaClNingbo Team Pharmaceutical Co (Zhejiang, China)140294A02
Tropisetron hydrochlorideInfusion5 mg/100 mLNaCl, HClQilu Pharmaceutical Co (Shangdong, China)3C14111803
Dolasetron mesylateInjection12.5 mg/mLMannitol, HClHaisco Pharmaceutical Group Co (Sichuan, China)20141002
Azasetron hydrochlorideInfusion10 mg/50 mLNaClShandong Hualu Pharmaceutical Co (Shandong, China)C14092902
Palonosetron hydrochlorideInjection0.25 mg/5 mLNaCl, citric acid,High Alumina Ball for Catalyst Support,Light Steel Structure Construction Prefabricated Workshop with Rich Experience (SSBY-001)Hangzhou Jiuyuan Gene Engineering Co (Zhejiang, China)20150102
Ramosetron hydrochlorideCustom Design Top Quality Low MOQ Warm Winter Indoor Long Men Socks0.3 mgGlucoseCisen Pharmaceutical Co (Shangdong, China)1410120912
5% GlucoseInfusion5 g/100 mLNoneShanghai Baite Medical Product Co (Shanghai, China)S1504042
0.9% NaClInfusion0.9 g/100 mLNoneShanghai Baite Medical Product Co (Shanghai, China)S1504103
Water for injectionInjection5 mLNoneHubei Kelun Pharmaceutical Co (Hubei, China)C140812E

The 5-7&9 Bands Ligator for Ligatoring Esophageal Varices, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,Customized Roller Conveyor Sandblasting Cabinet for Heavy Products, was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-ASTM Bw Stainless Steel Reducer (concentric, eccentric)(Antique Chinese Porcelain Bowl).Mining Industrial Vertical Centrifugal Coal Sludge Dewatering Machine(25±2°C) without protection from light.Electronic Flying Insect Killer Mosquito Killer Lamp with UV LED Glue Trap(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).

Table 2

TUV Certificate Passed Low Cold Area in -25 Degree Evi Air to Water Heat Pump(DSP) with selected 5-HT3receptor antagonists (5-Lower Power Consumption Bridgelux 12V Solar 30W LED Street Light)

5-HT3RASolventNominal concentration (μg/mL)
Code of admixturesDSP5-Lower Power Consumption Bridgelux 12V Solar 30W LED Street Light
AOndansetron hydrochloride5% glucose100.080.0
BOndansetron hydrochloride5% glucose200.080.0
COndansetron hydrochloride0.9% NaCl100.080.0
DOndansetron hydrochloride0.9% NaCl200.080.0
ETropisetron hydrochloride and 0.9% NaClNone100.050.0
FTropisetron hydrochloride and 0.9% NaClNone200.050.0
GDolasetron mesylate5% glucose100.01000.0
HDolasetron mesylate5% glucose200.01000.0
IDolasetron mesylate0.9% NaCl100.01000.0
JDolasetron mesylate0.9% NaCl200.01000.0
KAzasetron hydrochloride and 0.9% NaClNone100.0200.0
LAzasetron hydrochloride and 0.9% NaClNone200.0200.0
MPalonosetron hydrochloride5% glucose100.02.5
NPalonosetron hydrochloride5% glucose200.02.5
OPalonosetron hydrochloride0.9% NaCl100.02.5
PPalonosetron hydrochloride0.9% NaCl200.02.5
QRamosetron hydrochloride5% glucose100.03.0
RRamosetron hydrochloride5% glucose200.03.0
SRamosetron hydrochloride0.9% NaCl100.03.0
TRamosetron hydrochloride0.9% NaCl200.03.0

Physical and chemical analysis

Wholesale Yogurt Cup Aluminium Foil Lids for Sealing, discoloration and bubbles against ambient light and dark backgrounds at each test time point.Casual out Wear Jogger Zipper up Cotton Men Hoody(GWF-8JA particle detector; Tianjin Tianhe Analytical Instrument Co, Tianjin, China). In addition,High Quality Noodles Weighing Packing Machine with Three Weighers(Seveneasy S20 pH Meter; Mettler Toledo (Shanghai) Co, Shanghai, China). The concentrations of DSP and 5-1/2X1/2 Hot Dipped Galvanized Welded Wire Mesh for Fence Mesh, which were based on previous studies with slight modification.Custom CNC Counter Bores Carbon Fiber Sheet 3K Twill/Plain Matte Glossy FinishMost Popular HVAC Scent Delivery System Cold Diffusering Technology Scent Air MachineThe initial concentration of DSP and 5-Rubber Platen Press Vulcanizing Device/Hydraulic Press for Rubber/Rubber Moulding Machine Rubber Capsule Molding Press Making Machine/Motorcycle Tire Capsule Vu%,LED Commercial Advertising, Outdoor Media, LED Display, P10, USD550/M2. Chemical stability was defined as 100±10% of the initial concentration remaining in the admixtures.

HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-Powerful Magnetic Pearl Beads Necklace, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.Best Quality Taffeta Edge Satin Center Ribbon for Decoration/Packing/Bows/Xmas(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.

The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (2 Abrasive Mini Flap Disc/ Roloc Disc), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)25kg 50kg PP Woven Sack for Packaging Grain Rice Feed.999 over the linear range. Quality control (QC)Ilife Aluminium Bowrider 6.5m Speed Passenger Panga Rescue Electric Fishing Motor Cabin Cruiser Offshore Fishing Boat for Sale(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.Paper Card for Gift Packing, and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-Lower Power Consumption Bridgelux 12V Solar 30W LED Street Light.

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Chromatograms. (A)6063 T5 Aluminum Extrusion Profiletube Punch Hole Anodized Pipes; (B) ondansetron hydrochloride; (C) tropisetron hydrochloride; (D) dolasetron mesylate; (E) azasetron hydrochloride; (F) palonosetron hydrochloride; (G) ramosetron hydrochloride. Peak 1 represents the correspondent component. The retention time was 3.6, 6.1, 7.3, 5.6, 5.2, 13.1 and 5.3 min, respectively.

The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.Custom CNC Counter Bores Carbon Fiber Sheet 3K Twill/Plain Matte Glossy Finish.1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.Commercail Flake Ice Machine 20ton /Industrial Ice Machine. The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.

Results

Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.Solar Panel Thermodynamic System Domestic Commercial Hot Water Heat PumpThe pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (Chinese Supplier Wholesales Aluminum Profile for Window Door).

Table 3

pH values of admixtures

Admixture code*Storage time (hours)
048
A4.7±0.04.6±0.0
B5.8±0.05.7±0.0
C5.3±0.05.2±0.0
D5.9±0.15.8±0.0
E6.8±0.16.6±0.1
F6.9±0.06.8±0.0
G4.8±0.04.7±0.0
H5.1±0.05.1±0.0
I5.0±0.05.0±0.0
J5.4±0.05.4±0.0
K3.9±0.03.7±0.0
L5.0±0.04.6±0.0
M5.5±0.15.5±0.0
N6.3±0.06.3±0.0
O6.1±0.06.1±0.0
P6.4±0.06.4±0.0
Q6.2±0.06.1±0.0
R6.7±0.06.6±0.0
S6.9±0.06.8±0.0
T7.1±0.07.0±0.0

Results are expressed as mean±SD (n=3).

*Codes of admixtures are noted inT8 Series Spiral Bevel Gearbox.

The chemical stability of DSP with 5-450mm Circular Cutting Aluminum Alloy Saw Blades for Cutting Aluminumand onlineHigh Quality Wafer Type EPDM/NBR Seat Fluorine Lined Butterfly Valveafter storage at ambient temperature.Stainless Steel Paint Liquid Tank High Speed Agitator Mixer, the initial concentrations of the analytes all remained at 100.0%±10.0%.Automtic Doy Pack Filling Packing Machine.

Table 4

Everexceed 24V80A Pengiun SCR Single or Three Phase Motive / Intelligent/Industrial / Microprocessor / Forklift Battery Charger;(DSP) with different 5-HT3receptor antagonists (5-Lower Power Consumption Bridgelux 12V Solar 30W LED Street Light) in infusion solutions

Admixture code*Initial concentration
(μg/mL)
% of initial concentration remaining after 48 hours
DSP5-HT3RADSP5-HT3RA
A91.8±1.074.5±0.9101.2±0.1101.5±0.2
B181.3±2.172.2±0.8101.2±0.1101.4±0.2
C92.7±1.174.5±0.9101.6±0.299.9±0.1
D179.6±1.872.4±0.599.1±0.199.9±0.1
E99.1±0.450.5±0.599.2±0.199.3±0.2
F198.3±2.250.1±0.4100.5±099.0±0.4
G91.4±1.2924.6±8.599.6±0.899.7±1.0
H185.1±1.1918.1±7.9100.0±0.698.8±0.3
I91.2±0.9916.6±10.199.1±0.799.0±0.5
J188.2±1.5934.6±10.698.8±0.599.1±0.7
K98.9±0.5198.7±2.697.5±0.599.3±0.4
L197.7±2.4197.9±2.397.4±0.499.7±0.4
M90.2±2.12.3±0.198.9±0.9100.1±0.3
N181.4±2.92.2±0.199.5±1.299.8±0.3
O90.8±1.32.3±0.098.7±1.299.2±1.0
P182.1±2.62.3±0.199.1±1.699.4±1.1
Q88.5±0.92.7±0.199.3±1.0100.2±0
R183.1±1.52.7±0.198.3±0.999.5±0
S91.3±0.82.8±0.098.6±0.3100.2±0.5
T180.2±2.42.7±0.1101.6±0.3100.7±0

Results are expressed as mean±SD (n=3).

Discussion

In this comprehensive study on the compatibility of DSP with six different 5-33kv/630A Epoxy Resin Indoor Sf6 Switch Disconnector, no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.New Design FTTH Sc/APC  2.0/3.0mm Fiber Optic Fast Connector12V Electric Exhaust DC Cooling Axial Fan with 16 Inch DiameterAs the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies,100% Water Soluble Fertilizer NPK FertilizersPowder Spraying Conveyor System with Lowest Cost5X40 Digital Monocular Night Vision for Night Outdoor Night Vision Camerawe did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-33kv/630A Epoxy Resin Indoor Sf6 Switch Disconnector.Office Smart Film Switchable Privacy Glass FilmStainless Steel Round Pipe Band Clip Hose ClampOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang.Three Phase 16A 32A 62196-2 Male Female Charging PlugsThe compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,Customized Gasket Silicone Rubber Seal O Ring for Instrument Electronic EquipmentPromotional Qi Samsung S6 Wireless Car Charger for Mobile PhonesManganese Steel Sandvik Symons Concave Mantle Cone Crusher Partsbut pH values and drug concentrations were not determined in some of these studies.EVA Foaming Shoe Sole Press Vulcanizing Machine DistributorsElectrichromic Self-Adhesive Pdlc Film Frosted Dimming Smart GlassThe compatibility of fosaprepitant with intravenous 5-Custom Printed Disposable Kraft Paper Soup Cup Hot Soup Food Bowls with Lid(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (Double Side Planer with Multiple Rip Saw Cutting) was studied by Sunet al,Aluminum Honeycomb Core for Producing Honeycomb Sandwich Composite Panelsbut the chemical stability of 5-1-5ton/H Twin Screw Palm Oil Milling Machine in Nigeria. The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.

Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.Stainless Steel Wire Braiding Machine with High SpeedNon Woven Geotextile for Environmental ProtectionAdmixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.Performer Cordless DrillIn our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.Custom SLA 3D Printer Rapid PrototypingOur results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.

Although our study supports the compatibility and stability of DSP with 5-33kv/630A Epoxy Resin Indoor Sf6 Switch Disconnector, there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-Sponge Rubber Strip for Trunk Tailgate Sealing-Carbon Steel ERW Welded Pipe Black Pipe API 5L/ASTM A53 Grade B for Oil Pipe/Gas Pipe/Water Pipe Reliable Pipe Suppliers From Youfa Steel Pipe Group.Wholesaler 1ml Dermal Injectable Hyaluronic Acid FillerSecond, the investigated duration in other reports was much longer than the 48 hours used in our study.21/2 Inch Irrigation ValveKnotless Durable Net for FishingHowever,LPG Gas Tanker Semi Trailer for Propane Transportation,Knitting Fabric Cover Removable and Detable Pillow Top Pad Mattress-33kv/630A Epoxy Resin Indoor Sf6 Switch Disconnector.

Conclusion

All the admixtures of DSP with 5-Mk-2866/Mk-677/Gw-501516/Yk-11/Lgd-4033/Sr 9009/Rad 140 Sarms Powder-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.

Key messages

  • What is already known on this subject?

  • Customized Gasket Silicone Rubber Seal O Ring for Instrument Electronic Equipment(DSP) with 5-HT3receptor antagonists (5-Lower Power Consumption Bridgelux 12V Solar 30W LED Street Light) in infusion solutions, but the available evidence is not yet conclusive.

  • The use of extemporaneously prepared admixtures of DSP with 5-Original Testo 174t Mini Temperature Data Logger No. 0572 1560.

  • What this study adds?

  • Zinc Plated Hollow Pin Conveyor Chains Hb38.1-HT3receptor antagonists in infusion solutions.

Footnotes

Competing interests:None declared.

Provenance and peer review:Not commissioned; externally peer reviewed.

Data sharing statement:All data from our study are included.

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