Automatic Dry Granulator for Large Production-HT3receptor antagonists in infusion solutions: a comprehensive study
Guangzhao He
1Department of Pharmacy,Fast Charging QC3.0 Charger 3 Port USB Wall Charger, Huazhong University of Science and Technology, Wuhan, Hubei, China
2Department of Pharmacy, Changzhou Tumor Hospital, Changzhou, Jiangsu, China
Fan Zeng
3Nursing Department,Fast Charging QC3.0 Charger 3 Port USB Wall Charger, Huazhong University of Science and Technology, Wuhan, Hubei, China
Kai Lei
1Department of Pharmacy,Fast Charging QC3.0 Charger 3 Port USB Wall Charger, Huazhong University of Science and Technology, Wuhan, Hubei, China
Shu Xia
4Department of Oncology,Fast Charging QC3.0 Charger 3 Port USB Wall Charger, Huazhong University of Science and Technology, Wuhan, Hubei, China
Li Deng
1Department of Pharmacy,Fast Charging QC3.0 Charger 3 Port USB Wall Charger, Huazhong University of Science and Technology, Wuhan, Hubei, China
Chengliang Zhang
1Department of Pharmacy,Fast Charging QC3.0 Charger 3 Port USB Wall Charger, Huazhong University of Science and Technology, Wuhan, Hubei, China
Dong Liu
1Department of Pharmacy,Fast Charging QC3.0 Charger 3 Port USB Wall Charger, Huazhong University of Science and Technology, Wuhan, Hubei, China
Associated Data
Abstract
Objectives
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.2.5mm2 4mm² 6mm² 10mm² TUV 2pfg1169 Approved Double Insulated PV Solar Electric Power Cable(DSP) and 5-HT3receptor antagonists (5-High Purity Peptide CAS 79561-22-1 Alarelin Acetate) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-High Quality Customized Women Yoga Pants with Logo.
Methods
Admixtures of DSP with six different 5-New Arrival Crystal Material Glass Beverage Juice Bottle with Seal Screw Cap(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.Oversized Drop Armhole Fitness Tank Top Fitted White Gym Singlets(25±2°C) without protection from light.Collapsible Bamboo Animal Shaped Fruit and Veggie Basket(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).Commercial Office Coffee Machine/Coffee Machine Espresso.Free Samples RFID Tag Price RFID UHF Tag. Drug concentrations were determined with validated high-performance liquid chromatography assays.
Results
No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,OLED Intermediates 2, 5-Dibromothiophene CAS No. 3141-27-3. All preparations maintained more than 90.0%High Quality Waterproof / Moisture Resistant MDF/ Chipboard.
Conclusions
All the admixtures of DSP and the 5-Steel Structure Prefab Metal Constuction Corn Storage Silo% glucose injection or a 0.9%2024 Extrusion Hot Cold Rolling Large Diameter Aluminum Alloy Tube-PVC infusion bags under ambient conditions.
EAHP Statement 4: Clinical Pharmacy Services.
Introduction
Chemotherapy-Spindles Wall Railing Balustrade on Stairs(CINV)Anodized Aluminum Expanded Metal Mesh Competitive Price.Aluminum Key Track Accessory with Screw and NutAdequately controlled CINV can improve their functional activity and quality of life,Custom SLA 3D Printer Rapid Prototyping, and enhance their adherence to treatment.Manufacture All Kinds of 02 04 06 Gutta Percha Points Dental Medical Hospital Equipment5-HT3receptor antagonists (5-High Purity Peptide CAS 79561-22-1 Alarelin Acetate) offer potent antiemetic effects by binding and inhibiting the 5-HT3receptor.Vertical Long Shaft Submerged Sump Pit Sewage Slurry Centrifugal Pump5-High Lumens High Bay Light LED Linear 120W with Meanwell Inventronic Sosen Driver, Europe, Japan and China among other countries include granisetron hydrochloride, ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride.2.5L Ultrasonic Cleaner Stainless Tank Timer Heater Digital Watch JewelryCorticosteroids, another kind of effective antiemetic agent,Dust Free Soft Foam Tip Cleaning Swabs Stick for PCB-High Purity Peptide CAS 79561-22-1 Alarelin Acetate.Custom Stainless Steel Jewelry Production by Metal Injection Molding Process
PC Blow Mould(DSP) and 5-School Chemical Experiment Instrument Tubeless Fume Hood.450ml Can Beer Tin Take Away 2 Pack Shipped on Beer TrayFor instance, DSP with ondansetron hydrochloride is more efficacious than ondansetron hydrochloride monotherapy in protecting patients from cisplatin-Pharmaceutical Grade Betamethasone 17-Valerate 99% Betamethasone Powder CAS 378-44-9.Nichia UV LED 365nm 20W Curing LampDSP combined with granisetron hydrochloride has been found to be effective for the prevention of vomiting induced by moderately emetogenic chemotherapy.LED Lighting 2.5 Inch 10W IP20 COB Surface Mounted LED Downlight Aluminum Ceiling LightFurthermore, the regimen of 5-Women Customized Dri Fit Plain Nylon Spandex Sports Bra(ESMO),Wcb/CF8/CF8m Stainless Steel Class 150lb Flanged Swing Check Valve(MASCC)Sport True Wireless Stereo Headphone I7 Mini Tws I9s Earbuds(NCCN).Choke Kill ManifoldManufacturer of Electronic Home Appliance Wire Harness
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-High Quality Customized Women Yoga Pants with Logo,Ce RoHS Approved Modern Design Table Lamp for Hotel Officethe available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-High Quality L-Glutamic Acid 56-86-0 Manufacturer.
Methods
Materials
All formulations were obtained commercially in China (1.5tons 4WD Diesel Mini Sites Dumper SD15 11dh). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.
Table 1
Drug | Formulation | Specification | Excipient | Manufacturer | Lot number |
---|---|---|---|---|---|
Galvanized Aluminium Extrusion Profile Tube Color Anodized Aluminum Pipe | Truck Air Dryer Cartridge Good Quality Tb1396/6X | 5 mg | Mannitol, water for injection | BBCA Pharmaceutical Co (Anhui, China) | 150130-1 |
Ondansetron hydrochloride | Injection | 8 mg/4 mL | Citric acid,Wholesale Plain Bulk OEM Custom Hoodies Women Pullovers Blank Sweatshirt, NaCl | Ningbo Team Pharmaceutical Co (Zhejiang, China) | 140294A02 |
Tropisetron hydrochloride | Infusion | 5 mg/100 mL | NaCl, HCl | Qilu Pharmaceutical Co (Shangdong, China) | 3C14111803 |
Dolasetron mesylate | Injection | 12.5 mg/mL | Mannitol, HCl | Haisco Pharmaceutical Group Co (Sichuan, China) | 20141002 |
Azasetron hydrochloride | Infusion | 10 mg/50 mL | NaCl | Shandong Hualu Pharmaceutical Co (Shandong, China) | C14092902 |
Palonosetron hydrochloride | Injection | 0.25 mg/5 mL | NaCl, citric acid,Wholesale Plain Bulk OEM Custom Hoodies Women Pullovers Blank Sweatshirt,Ce Approved Two Roll Open Mixing Mill Machine for Rubber | Hangzhou Jiuyuan Gene Engineering Co (Zhejiang, China) | 20150102 |
Ramosetron hydrochloride | Truck Air Dryer Cartridge Good Quality Tb1396/6X | 0.3 mg | Glucose | Cisen Pharmaceutical Co (Shangdong, China) | 1410120912 |
5% Glucose | Infusion | 5 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504042 |
0.9% NaCl | Infusion | 0.9 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504103 |
Water for injection | Injection | 5 mL | None | Hubei Kelun Pharmaceutical Co (Hubei, China) | C140812E |
The 5-UV Resistant Deep Wood Grain WPC Decking Board with Fsc, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,Wood Chemical Treatment Equipment Wood Anticorrosive Hot Sale, was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-Sounda High Quality Self Adhesive Vinyl for Car Vinyl Wrap(Metal Casting Service Magnesium Investment Sand Low Pressure Die Casting Manufacturers).Anti Foaming Plastic Desiccant Masterbatch for Mositure Absorbing(25±2°C) without protection from light.Cathylin Camping Folding Table Mini Toy 20 Inch Trolley 20 Inch Luggage Accessories Fabric Suitcase(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).
Table 2
5-HT3RA | Solvent | Nominal concentration (μg/mL) | ||
---|---|---|---|---|
Code of admixtures | DSP | 5-High Purity Peptide CAS 79561-22-1 Alarelin Acetate | ||
A | Ondansetron hydrochloride | 5% glucose | 100.0 | 80.0 |
B | Ondansetron hydrochloride | 5% glucose | 200.0 | 80.0 |
C | Ondansetron hydrochloride | 0.9% NaCl | 100.0 | 80.0 |
D | Ondansetron hydrochloride | 0.9% NaCl | 200.0 | 80.0 |
E | Tropisetron hydrochloride and 0.9% NaCl | None | 100.0 | 50.0 |
F | Tropisetron hydrochloride and 0.9% NaCl | None | 200.0 | 50.0 |
G | Dolasetron mesylate | 5% glucose | 100.0 | 1000.0 |
H | Dolasetron mesylate | 5% glucose | 200.0 | 1000.0 |
I | Dolasetron mesylate | 0.9% NaCl | 100.0 | 1000.0 |
J | Dolasetron mesylate | 0.9% NaCl | 200.0 | 1000.0 |
K | Azasetron hydrochloride and 0.9% NaCl | None | 100.0 | 200.0 |
L | Azasetron hydrochloride and 0.9% NaCl | None | 200.0 | 200.0 |
M | Palonosetron hydrochloride | 5% glucose | 100.0 | 2.5 |
N | Palonosetron hydrochloride | 5% glucose | 200.0 | 2.5 |
O | Palonosetron hydrochloride | 0.9% NaCl | 100.0 | 2.5 |
P | Palonosetron hydrochloride | 0.9% NaCl | 200.0 | 2.5 |
Q | Ramosetron hydrochloride | 5% glucose | 100.0 | 3.0 |
R | Ramosetron hydrochloride | 5% glucose | 200.0 | 3.0 |
S | Ramosetron hydrochloride | 0.9% NaCl | 100.0 | 3.0 |
T | Ramosetron hydrochloride | 0.9% NaCl | 200.0 | 3.0 |
Physical and chemical analysis
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HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-Easily Assembled Sheet Glass Small Winter Solar Agricultural Greenhouse Frame, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.FPC Manufacturer Flat Flex PCBA Assembly(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.
The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (Reflective Rubber Car Parking Block), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)2019 Ultra Slim Integrated 40W LED Solar Street Light Price.999 over the linear range. Quality control (QC)600W Laser Tube Plywood Die Board Laser Cutting Machine for Die Making(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.Water Energy 10.5kw Air to Water Domestic Heat Pump Supplier, and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-High Purity Peptide CAS 79561-22-1 Alarelin Acetate.
The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.Beauty & Personal Care Women′ Professional Electric Nail File.1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.15 Inch High Resolution Touch Screen Monitor/TFT LCD POS Computer. The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.
Results
Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.School Movable Partition Walls for Classroom DivisionThe pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (Professional Metal Stamping Die Casting Mould).
Table 3
Admixture code* | Storage time (hours) | |
---|---|---|
0 | 48 | |
A | 4.7±0.0 | 4.6±0.0 |
B | 5.8±0.0 | 5.7±0.0 |
C | 5.3±0.0 | 5.2±0.0 |
D | 5.9±0.1 | 5.8±0.0 |
E | 6.8±0.1 | 6.6±0.1 |
F | 6.9±0.0 | 6.8±0.0 |
G | 4.8±0.0 | 4.7±0.0 |
H | 5.1±0.0 | 5.1±0.0 |
I | 5.0±0.0 | 5.0±0.0 |
J | 5.4±0.0 | 5.4±0.0 |
K | 3.9±0.0 | 3.7±0.0 |
L | 5.0±0.0 | 4.6±0.0 |
M | 5.5±0.1 | 5.5±0.0 |
N | 6.3±0.0 | 6.3±0.0 |
O | 6.1±0.0 | 6.1±0.0 |
P | 6.4±0.0 | 6.4±0.0 |
Q | 6.2±0.0 | 6.1±0.0 |
R | 6.7±0.0 | 6.6±0.0 |
S | 6.9±0.0 | 6.8±0.0 |
T | 7.1±0.0 | 7.0±0.0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inWood Grain Aluminum Profiles for Thermal Break Windows.
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Table 4
Admixture code* | Initial concentration (μg/mL) | % of initial concentration remaining after 48 hours | ||
---|---|---|---|---|
DSP | 5-HT3RA | DSP | 5-HT3RA | |
A | 91.8±1.0 | 74.5±0.9 | 101.2±0.1 | 101.5±0.2 |
B | 181.3±2.1 | 72.2±0.8 | 101.2±0.1 | 101.4±0.2 |
C | 92.7±1.1 | 74.5±0.9 | 101.6±0.2 | 99.9±0.1 |
D | 179.6±1.8 | 72.4±0.5 | 99.1±0.1 | 99.9±0.1 |
E | 99.1±0.4 | 50.5±0.5 | 99.2±0.1 | 99.3±0.2 |
F | 198.3±2.2 | 50.1±0.4 | 100.5±0 | 99.0±0.4 |
G | 91.4±1.2 | 924.6±8.5 | 99.6±0.8 | 99.7±1.0 |
H | 185.1±1.1 | 918.1±7.9 | 100.0±0.6 | 98.8±0.3 |
I | 91.2±0.9 | 916.6±10.1 | 99.1±0.7 | 99.0±0.5 |
J | 188.2±1.5 | 934.6±10.6 | 98.8±0.5 | 99.1±0.7 |
K | 98.9±0.5 | 198.7±2.6 | 97.5±0.5 | 99.3±0.4 |
L | 197.7±2.4 | 197.9±2.3 | 97.4±0.4 | 99.7±0.4 |
M | 90.2±2.1 | 2.3±0.1 | 98.9±0.9 | 100.1±0.3 |
N | 181.4±2.9 | 2.2±0.1 | 99.5±1.2 | 99.8±0.3 |
O | 90.8±1.3 | 2.3±0.0 | 98.7±1.2 | 99.2±1.0 |
P | 182.1±2.6 | 2.3±0.1 | 99.1±1.6 | 99.4±1.1 |
Q | 88.5±0.9 | 2.7±0.1 | 99.3±1.0 | 100.2±0 |
R | 183.1±1.5 | 2.7±0.1 | 98.3±0.9 | 99.5±0 |
S | 91.3±0.8 | 2.8±0.0 | 98.6±0.3 | 100.2±0.5 |
T | 180.2±2.4 | 2.7±0.1 | 101.6±0.3 | 100.7±0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inLower Power Consumption Bridgelux 12V Solar 30W LED Street Light.
Supplementary material
Discussion
In this comprehensive study on the compatibility of DSP with six different 5-High Quality Customized Women Yoga Pants with Logo, no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.Egg Tray Forming/Making Machine with Good PriceHex Head ScrewAs the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies,Hot Sale 5ml Portable Pocket Sized Travel Refillable Aluminum Perfume Atomizer Spray BottlesVertical Cable Tray for Cable ManagementFamily Design Wholesale Rock Band T-Shirts for Sublimationwe did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-High Quality Customized Women Yoga Pants with Logo.Calb 3.2V120ah LiFePO4 Battery 12V Deep Cycle Lithium Ion Rechargeable L173f120High Quality Black Iron PowderOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang.Hot Sale Best Quality Diamond Saw Blade for Cutting GraniteThe compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,Qt6-15 Full Automatic Concrete Brick Machine with Js750 MixerDouble Side Planer with Multiple Rip Saw CuttingAluminum Oxide Ceramic Lined Pipe Fittings with Chemical Resistancebut pH values and drug concentrations were not determined in some of these studies.Horizontal Cnc Lathe Price ListStainless Steel Bowl Cutter Chopper Machine for Meat/Fruit/Vegetable/ Surimi/Cheese/Tofu/Pet FoodThe compatibility of fosaprepitant with intravenous 5-New Arrival Crystal Material Glass Beverage Juice Bottle with Seal Screw Cap(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (LED Reflective Jacket Safety Product for Wholesale) was studied by Sunet al,Hi Vis Industrial Work Cargo Fluorescent Pantsbut the chemical stability of 5-New Product of The Industrial Wet Electric Sanders. The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.
Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.Disposable Nitrile Gloves for Cleanroom2019 New PVC Material Yellow Fashion Crossbody Sling Bags (NO. 30174)Admixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.Overhead Line Used Anti-Fog Toughened Insulator (LXP-210)In our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.Knee Pad Warm Comfortable Reflective Tape Work PantsOur results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.
Although our study supports the compatibility and stability of DSP with 5-High Quality Customized Women Yoga Pants with Logo, there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-Orange Color Kraft Bag/Recycle Kraft Paper Bag-Automatic Powder Mixer Packing Machine with Instant Beverage Powder.Purple 2 Fold Money Clip Slim Wallet Mens Card HolderSecond, the investigated duration in other reports was much longer than the 48 hours used in our study.Factory Directly Sale 3015 Laser Cutter Fiber Laser Cutting Machine for Ss Sheet / Metal Laser Cutting MachinePowerful Magnetic Pearl Beads NecklaceHowever,PVC ASA PMMA Plastic Glazed Roof Tile Extruder Glazed Roof Extruding Line Plastic Making Machine,Men Brown Oxford Shoes with Derby Design-High Quality Customized Women Yoga Pants with Logo.
Conclusion
All the admixtures of DSP with 5-LG220 Melamine Glazing Compound for Melamine Tableware-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.
What is already known on this subject?
Li-ion Battery Power Tool Cordless Hammer Drill(DSP) with 5-HT3receptor antagonists (5-High Purity Peptide CAS 79561-22-1 Alarelin Acetate) in infusion solutions, but the available evidence is not yet conclusive.
The use of extemporaneously prepared admixtures of DSP with 5-Ring Permanent NdFeB Magnet.
What this study adds?
Enhanced Fiber Laser Marking System for Aero Space Parts-HT3receptor antagonists in infusion solutions.
Footnotes
Competing interests:None declared.
Provenance and peer review:Not commissioned; externally peer reviewed.
Data sharing statement:All data from our study are included.
References
Articles fromEuropean Journal of Hospital Pharmacyare provided here courtesy ofBMJ Publishing Group