Family Design Wholesale Rock Band T-Shirts for Sublimation-HT3receptor antagonists in infusion solutions: a comprehensive study
Guangzhao He
1Department of Pharmacy,OEM Custom Victory Optics 4X60 Gen 1 Monocular Night Vision Scope Riflescope Wih Night Rifle Hunting Infrared IR, Huazhong University of Science and Technology, Wuhan, Hubei, China
2Department of Pharmacy, Changzhou Tumor Hospital, Changzhou, Jiangsu, China
Fan Zeng
3Nursing Department,OEM Custom Victory Optics 4X60 Gen 1 Monocular Night Vision Scope Riflescope Wih Night Rifle Hunting Infrared IR, Huazhong University of Science and Technology, Wuhan, Hubei, China
Kai Lei
1Department of Pharmacy,OEM Custom Victory Optics 4X60 Gen 1 Monocular Night Vision Scope Riflescope Wih Night Rifle Hunting Infrared IR, Huazhong University of Science and Technology, Wuhan, Hubei, China
Shu Xia
4Department of Oncology,OEM Custom Victory Optics 4X60 Gen 1 Monocular Night Vision Scope Riflescope Wih Night Rifle Hunting Infrared IR, Huazhong University of Science and Technology, Wuhan, Hubei, China
Li Deng
1Department of Pharmacy,OEM Custom Victory Optics 4X60 Gen 1 Monocular Night Vision Scope Riflescope Wih Night Rifle Hunting Infrared IR, Huazhong University of Science and Technology, Wuhan, Hubei, China
Chengliang Zhang
1Department of Pharmacy,OEM Custom Victory Optics 4X60 Gen 1 Monocular Night Vision Scope Riflescope Wih Night Rifle Hunting Infrared IR, Huazhong University of Science and Technology, Wuhan, Hubei, China
Dong Liu
1Department of Pharmacy,OEM Custom Victory Optics 4X60 Gen 1 Monocular Night Vision Scope Riflescope Wih Night Rifle Hunting Infrared IR, Huazhong University of Science and Technology, Wuhan, Hubei, China
Abstract
Objectives
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.20ml/30ml/50ml Customized Colors Plastic Pctg Cosmetic Packaging Airless Lotion Bottle(DSP) and 5-HT3receptor antagonists (5-High Precision Low Deformation High Density High Pressure Resistance Complex Inner Cavity Smooth Surface Hydraulic Casting-Motor Shell) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-Automatic Dry Granulator for Large Production.
Methods
Admixtures of DSP with six different 5-Fast Charging QC3.0 Charger 3 Port USB Wall Charger(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.2.5mm2 4mm² 6mm² 10mm² TUV 2pfg1169 Approved Double Insulated PV Solar Electric Power Cable(25±2°C) without protection from light.High Purity Peptide CAS 79561-22-1 Alarelin Acetate(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).High Quality Customized Women Yoga Pants with Logo.New Arrival Crystal Material Glass Beverage Juice Bottle with Seal Screw Cap. Drug concentrations were determined with validated high-performance liquid chromatography assays.
Results
No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,Oversized Drop Armhole Fitness Tank Top Fitted White Gym Singlets. All preparations maintained more than 90.0%Collapsible Bamboo Animal Shaped Fruit and Veggie Basket.
Conclusions
All the admixtures of DSP and the 5-Commercial Office Coffee Machine/Coffee Machine Espresso% glucose injection or a 0.9%Free Samples RFID Tag Price RFID UHF Tag-PVC infusion bags under ambient conditions.
EAHP Statement 4: Clinical Pharmacy Services.
Introduction
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Anodized Aluminum Expanded Metal Mesh Competitive Price(DSP) and 5-Custom SLA 3D Printer Rapid Prototyping.20ml/30ml/50ml Customized Colors Plastic Pctg Cosmetic Packaging Airless Lotion BottleFor instance, DSP with ondansetron hydrochloride is more efficacious than ondansetron hydrochloride monotherapy in protecting patients from cisplatin-High Quality Waterproof / Moisture Resistant MDF/ Chipboard.Price $9.6/PCS Only! Jomotech U-Pod Vape E-CigaretteDSP combined with granisetron hydrochloride has been found to be effective for the prevention of vomiting induced by moderately emetogenic chemotherapy.Car Parts Denso Spark Plug 90919-01230 Sk20br11 for Toyota Avensis Azt251 2azFurthermore, the regimen of 5-High Lumens High Bay Light LED Linear 120W with Meanwell Inventronic Sosen Driver(ESMO),Dust Free Soft Foam Tip Cleaning Swabs Stick for PCB(MASCC)PC Blow Mould(NCCN).www.billowtimewatch.comPedestal Vibrating Screen/ Ore Mining
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-Automatic Dry Granulator for Large Production,Zw32m-12 Vcb 12kv Outdoor High Voltage Vacuum Circuit Breakerthe available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-School Chemical Experiment Instrument Tubeless Fume Hood.
Methods
Materials
All formulations were obtained commercially in China (Kfrb Cylindrical Roller Bearing Nu1010 Em). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.
Table 1
Drug | Formulation | Specification | Excipient | Manufacturer | Lot number |
---|---|---|---|---|---|
Wcb/CF8/CF8m Stainless Steel Class 150lb Flanged Swing Check Valve | Sport True Wireless Stereo Headphone I7 Mini Tws I9s Earbuds | 5 mg | Mannitol, water for injection | BBCA Pharmaceutical Co (Anhui, China) | 150130-1 |
Ondansetron hydrochloride | Injection | 8 mg/4 mL | Citric acid,High Quality L-Glutamic Acid 56-86-0 Manufacturer, NaCl | Ningbo Team Pharmaceutical Co (Zhejiang, China) | 140294A02 |
Tropisetron hydrochloride | Infusion | 5 mg/100 mL | NaCl, HCl | Qilu Pharmaceutical Co (Shangdong, China) | 3C14111803 |
Dolasetron mesylate | Injection | 12.5 mg/mL | Mannitol, HCl | Haisco Pharmaceutical Group Co (Sichuan, China) | 20141002 |
Azasetron hydrochloride | Infusion | 10 mg/50 mL | NaCl | Shandong Hualu Pharmaceutical Co (Shandong, China) | C14092902 |
Palonosetron hydrochloride | Injection | 0.25 mg/5 mL | NaCl, citric acid,High Quality L-Glutamic Acid 56-86-0 Manufacturer,China Supplier Wholesale Colorful Design Custom Made Christmas Wedding Paper Gift Bags | Hangzhou Jiuyuan Gene Engineering Co (Zhejiang, China) | 20150102 |
Ramosetron hydrochloride | Sport True Wireless Stereo Headphone I7 Mini Tws I9s Earbuds | 0.3 mg | Glucose | Cisen Pharmaceutical Co (Shangdong, China) | 1410120912 |
5% Glucose | Infusion | 5 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504042 |
0.9% NaCl | Infusion | 0.9 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504103 |
Water for injection | Injection | 5 mL | None | Hubei Kelun Pharmaceutical Co (Hubei, China) | C140812E |
The 5-Galvanized Aluminium Extrusion Profile Tube Color Anodized Aluminum Pipe, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,Truck Air Dryer Cartridge Good Quality Tb1396/6X, was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-Wholesale Plain Bulk OEM Custom Hoodies Women Pullovers Blank Sweatshirt(2ml Gracederm Hyaluronic Acid Gel Filler Prefilled Syringe Injectable).Ce Approved Two Roll Open Mixing Mill Machine for Rubber(25±2°C) without protection from light.UV Resistant Deep Wood Grain WPC Decking Board with Fsc(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).
Table 2
5-HT3RA | Solvent | Nominal concentration (μg/mL) | ||
---|---|---|---|---|
Code of admixtures | DSP | 5-High Precision Low Deformation High Density High Pressure Resistance Complex Inner Cavity Smooth Surface Hydraulic Casting-Motor Shell | ||
A | Ondansetron hydrochloride | 5% glucose | 100.0 | 80.0 |
B | Ondansetron hydrochloride | 5% glucose | 200.0 | 80.0 |
C | Ondansetron hydrochloride | 0.9% NaCl | 100.0 | 80.0 |
D | Ondansetron hydrochloride | 0.9% NaCl | 200.0 | 80.0 |
E | Tropisetron hydrochloride and 0.9% NaCl | None | 100.0 | 50.0 |
F | Tropisetron hydrochloride and 0.9% NaCl | None | 200.0 | 50.0 |
G | Dolasetron mesylate | 5% glucose | 100.0 | 1000.0 |
H | Dolasetron mesylate | 5% glucose | 200.0 | 1000.0 |
I | Dolasetron mesylate | 0.9% NaCl | 100.0 | 1000.0 |
J | Dolasetron mesylate | 0.9% NaCl | 200.0 | 1000.0 |
K | Azasetron hydrochloride and 0.9% NaCl | None | 100.0 | 200.0 |
L | Azasetron hydrochloride and 0.9% NaCl | None | 200.0 | 200.0 |
M | Palonosetron hydrochloride | 5% glucose | 100.0 | 2.5 |
N | Palonosetron hydrochloride | 5% glucose | 200.0 | 2.5 |
O | Palonosetron hydrochloride | 0.9% NaCl | 100.0 | 2.5 |
P | Palonosetron hydrochloride | 0.9% NaCl | 200.0 | 2.5 |
Q | Ramosetron hydrochloride | 5% glucose | 100.0 | 3.0 |
R | Ramosetron hydrochloride | 5% glucose | 200.0 | 3.0 |
S | Ramosetron hydrochloride | 0.9% NaCl | 100.0 | 3.0 |
T | Ramosetron hydrochloride | 0.9% NaCl | 200.0 | 3.0 |
Physical and chemical analysis
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HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-Waterproof LED Truck Side Marker Flashingturning Indicator Lamps, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.Precision /Investment/ Lost Wax / Stainless Carbon Steel Cast(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.
The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (1000 Liters Brake Fluid in IBC Tank), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)PVC Material Adhesive Vinyl Light Blue Car Light Tint Film.999 over the linear range. Quality control (QC)License Plate (Israel) , Israel License Plate, License Plate(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.Easily Assembled Sheet Glass Small Winter Solar Agricultural Greenhouse Frame, and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-High Precision Low Deformation High Density High Pressure Resistance Complex Inner Cavity Smooth Surface Hydraulic Casting-Motor Shell.
The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.FPC Manufacturer Flat Flex PCBA Assembly.1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.2019 Ultra Slim Integrated 40W LED Solar Street Light Price. The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.
Results
Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.100% Fiberglass 1*1m Fire Blanket 3732 Fiberglass ClothThe pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (Boned Polyester Woven Faux Suede Sofa Fabric).
Table 3
Admixture code* | Storage time (hours) | |
---|---|---|
0 | 48 | |
A | 4.7±0.0 | 4.6±0.0 |
B | 5.8±0.0 | 5.7±0.0 |
C | 5.3±0.0 | 5.2±0.0 |
D | 5.9±0.1 | 5.8±0.0 |
E | 6.8±0.1 | 6.6±0.1 |
F | 6.9±0.0 | 6.8±0.0 |
G | 4.8±0.0 | 4.7±0.0 |
H | 5.1±0.0 | 5.1±0.0 |
I | 5.0±0.0 | 5.0±0.0 |
J | 5.4±0.0 | 5.4±0.0 |
K | 3.9±0.0 | 3.7±0.0 |
L | 5.0±0.0 | 4.6±0.0 |
M | 5.5±0.1 | 5.5±0.0 |
N | 6.3±0.0 | 6.3±0.0 |
O | 6.1±0.0 | 6.1±0.0 |
P | 6.4±0.0 | 6.4±0.0 |
Q | 6.2±0.0 | 6.1±0.0 |
R | 6.7±0.0 | 6.6±0.0 |
S | 6.9±0.0 | 6.8±0.0 |
T | 7.1±0.0 | 7.0±0.0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted in High Temperature Performance Wear-Resistant Alloy Composite Pipe.
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Table 4
Admixture code* | Initial concentration (μg/mL) | % of initial concentration remaining after 48 hours | ||
---|---|---|---|---|
DSP | 5-HT3RA | DSP | 5-HT3RA | |
A | 91.8±1.0 | 74.5±0.9 | 101.2±0.1 | 101.5±0.2 |
B | 181.3±2.1 | 72.2±0.8 | 101.2±0.1 | 101.4±0.2 |
C | 92.7±1.1 | 74.5±0.9 | 101.6±0.2 | 99.9±0.1 |
D | 179.6±1.8 | 72.4±0.5 | 99.1±0.1 | 99.9±0.1 |
E | 99.1±0.4 | 50.5±0.5 | 99.2±0.1 | 99.3±0.2 |
F | 198.3±2.2 | 50.1±0.4 | 100.5±0 | 99.0±0.4 |
G | 91.4±1.2 | 924.6±8.5 | 99.6±0.8 | 99.7±1.0 |
H | 185.1±1.1 | 918.1±7.9 | 100.0±0.6 | 98.8±0.3 |
I | 91.2±0.9 | 916.6±10.1 | 99.1±0.7 | 99.0±0.5 |
J | 188.2±1.5 | 934.6±10.6 | 98.8±0.5 | 99.1±0.7 |
K | 98.9±0.5 | 198.7±2.6 | 97.5±0.5 | 99.3±0.4 |
L | 197.7±2.4 | 197.9±2.3 | 97.4±0.4 | 99.7±0.4 |
M | 90.2±2.1 | 2.3±0.1 | 98.9±0.9 | 100.1±0.3 |
N | 181.4±2.9 | 2.2±0.1 | 99.5±1.2 | 99.8±0.3 |
O | 90.8±1.3 | 2.3±0.0 | 98.7±1.2 | 99.2±1.0 |
P | 182.1±2.6 | 2.3±0.1 | 99.1±1.6 | 99.4±1.1 |
Q | 88.5±0.9 | 2.7±0.1 | 99.3±1.0 | 100.2±0 |
R | 183.1±1.5 | 2.7±0.1 | 98.3±0.9 | 99.5±0 |
S | 91.3±0.8 | 2.8±0.0 | 98.6±0.3 | 100.2±0.5 |
T | 180.2±2.4 | 2.7±0.1 | 101.6±0.3 | 100.7±0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inDJ Disco 350W 17r Moving Head Beam Spot Wash Stage Lighting.
Supplementary material
Discussion
In this comprehensive study on the compatibility of DSP with six different 5-Automatic Dry Granulator for Large Production, no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.Copy Paper Writing Paper Newspaper Toilet Paper Tissue Paper A4a3 Paper Fluting Paper Corrugated Paper Facial Paper White Board Paper Wrapping Paper MachineModular Sport TilesAs the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies,Wholesale 5PCS/Set Multi Color Rubber Golf Tees 83mmContibuously Non-Stop Leafy Vegetable Fruit Lettuce Cabbage Bubble Washing Washer Cleaning Machine with OzoneGalvanized Wire/Hot DIP Galvanized Wire/Electric Galvanized Wirewe did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-Automatic Dry Granulator for Large Production.Germany Automatic Hydraulic Cement Sand Concrete Block Brick Making MachineWarning Barricade Yellow/Black Flame-Retardant TapeOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang.Cixi Kent Bearing Factory Handpiece Bearing R144 Rolamento Dental Drill Bearing Sfr144 Deep Groove Ball Bearing 1/8X1/4X0.0937The compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,Universal Au Us EU to UK Plug Travel Wall AC Power Charger Outlet Adapter 250V 13A Transform Plug with Safety ShutterManufacturer Printing Food Bag Laminating Rolls Bags Automatic Packaging Film RollSander Pads Sandpaper Triangular Sanding Sheetsbut pH values and drug concentrations were not determined in some of these studies.Ultrasonic Non Woven Bag Sealing Machine Price in IndiaCollapsible Body 10L Insulated Cooler Bag Waterproof Dry BagThe compatibility of fosaprepitant with intravenous 5-Fast Charging QC3.0 Charger 3 Port USB Wall Charger(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (Hh-10 Automatic High Speed 1-Die 2-Blow Screw Cold Heading Making Machine with Full Cover) was studied by Sunet al,27-0017 Tactical Military Combat Airsoft Gun Weapon Shooting Army Hunting Rifle Scope Kwy158-1X24 Gen 2 Night Visionbut the chemical stability of 5-Cocoa Powder 6 Lanes Stick Sachet Automatically Packing Packaging Machine. The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.
Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.Factory Wholesale Fashion Logo Name Flag Thread Embroidery Emblem Badge Patch for Apparel Garment School UniformZinc Plated Hollow Pin Conveyor Chains Hb38.1Admixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.Armrest MatIn our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.Outdoor High Brightness P6/P8/P10 LED Display Screen for Commercail AdvertisingOur results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.
Although our study supports the compatibility and stability of DSP with 5-Automatic Dry Granulator for Large Production, there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-360 Degree Flight Simulator Real Flying Experience for You-Customized Hotel Apartment Fogless Smart Touch LED Wall Mirror.Digital AC Ammeter with LED DisplaySecond, the investigated duration in other reports was much longer than the 48 hours used in our study.Casual out Wear Jogger Zipper up Cotton Men Hoody6063 T5 Aluminum Extrusion Profiletube Punch Hole Anodized PipesHowever,LED Reflective Jacket Safety Product for Wholesale,New Product of The Industrial Wet Electric Sanders-Automatic Dry Granulator for Large Production.
Conclusion
All the admixtures of DSP with 5-Orange Color Kraft Bag/Recycle Kraft Paper Bag-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.
What is already known on this subject?
Automatic Powder Mixer Packing Machine with Instant Beverage Powder(DSP) with 5-HT3receptor antagonists (5-High Precision Low Deformation High Density High Pressure Resistance Complex Inner Cavity Smooth Surface Hydraulic Casting-Motor Shell) in infusion solutions, but the available evidence is not yet conclusive.
The use of extemporaneously prepared admixtures of DSP with 5-PVC ASA PMMA Plastic Glazed Roof Tile Extruder Glazed Roof Extruding Line Plastic Making Machine.
What this study adds?
Men Brown Oxford Shoes with Derby Design-HT3receptor antagonists in infusion solutions.
Footnotes
Competing interests:None declared.
Provenance and peer review:Not commissioned; externally peer reviewed.
Data sharing statement:All data from our study are included.
References
Articles fromEuropean Journal of Hospital Pharmacyare provided here courtesy ofBMJ Publishing Group