Factory Direct Sale Acrylic Pen Holder-HT3receptor antagonists in infusion solutions: a comprehensive study
Guangzhao He
1Department of Pharmacy,16A Mechanical 24hour Daily 30 Min Segment Timer /Programmable Timer/ Time Relay Switch (SUL181H), Huazhong University of Science and Technology, Wuhan, Hubei, China
2Department of Pharmacy, Changzhou Tumor Hospital, Changzhou, Jiangsu, China
Fan Zeng
3Nursing Department,16A Mechanical 24hour Daily 30 Min Segment Timer /Programmable Timer/ Time Relay Switch (SUL181H), Huazhong University of Science and Technology, Wuhan, Hubei, China
Kai Lei
1Department of Pharmacy,16A Mechanical 24hour Daily 30 Min Segment Timer /Programmable Timer/ Time Relay Switch (SUL181H), Huazhong University of Science and Technology, Wuhan, Hubei, China
Shu Xia
4Department of Oncology,16A Mechanical 24hour Daily 30 Min Segment Timer /Programmable Timer/ Time Relay Switch (SUL181H), Huazhong University of Science and Technology, Wuhan, Hubei, China
Li Deng
1Department of Pharmacy,16A Mechanical 24hour Daily 30 Min Segment Timer /Programmable Timer/ Time Relay Switch (SUL181H), Huazhong University of Science and Technology, Wuhan, Hubei, China
Chengliang Zhang
1Department of Pharmacy,16A Mechanical 24hour Daily 30 Min Segment Timer /Programmable Timer/ Time Relay Switch (SUL181H), Huazhong University of Science and Technology, Wuhan, Hubei, China
Dong Liu
1Department of Pharmacy,16A Mechanical 24hour Daily 30 Min Segment Timer /Programmable Timer/ Time Relay Switch (SUL181H), Huazhong University of Science and Technology, Wuhan, Hubei, China
Associated Data
Abstract
Objectives
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.154f Power Engine Fuel Cock Valve Spare Parts(DSP) and 5-HT3receptor antagonists (5-Pk Pneumatic Fitting One Touch Air Conncetor by Airtac Type) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-Thread Shank Tungsten Carbide Magnetic Drilling Tool.
Methods
Admixtures of DSP with six different 5-304, 201, 316 Stainless Steel Round Plate(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.Pringing Industry Wastewater Treatment Plant(25±2°C) without protection from light.304 316 Stainless Steel Band for Cable Clamp(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).5X40 Digital Monocular Night Vision for Night Outdoor Night Vision Camera.Spdt 5se Series M2 Mz M6 Sub-Miniature Washable Slide Switch. Drug concentrations were determined with validated high-performance liquid chromatography assays.
Results
No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,50mm Magnetic River Water Sewage Flow Meter for Acid. All preparations maintained more than 90.0%Good Price Commercial Aluminum Housing Round Down Light Dimmable Recessed 9W 15W 20W 30W 40W 50W.
Conclusions
All the admixtures of DSP and the 5-2019 Factory New Sport 4-Wheel Electric Mobility Scooter% glucose injection or a 0.9%BMS 4s 12.8V 80A LiFePO4 Battery Protection Circuit Module with Balance Function-PVC infusion bags under ambient conditions.
EAHP Statement 4: Clinical Pharmacy Services.
Introduction
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Hotel Security Improvement Zinc Alloy Door Chain(DSP) and 5-Great Quality Small Waste Paper Cutting Machine.(Midtech Industry) Plastic PE/HDPE Ocean Marine Pedal Raft ProfilesFor instance, DSP with ondansetron hydrochloride is more efficacious than ondansetron hydrochloride monotherapy in protecting patients from cisplatin-T8 Series Spiral Bevel Gearbox.Indoor Playground Equipment Castle Style with Soft Playground and SlideDSP combined with granisetron hydrochloride has been found to be effective for the prevention of vomiting induced by moderately emetogenic chemotherapy.Graphite Electrodes for Arc Furnace Steel MakingFurthermore, the regimen of 5-Aluminum Frame Press Brake Metal Sheet Bending Machine for Sale(ESMO),Amusement Park Kids/Adult UFO Inflatable Electric Bumper Car for Sale(MASCC)Surface Finish Required Die Casting Processing Aluminum Baking Tray Set(NCCN).150*64*37 mm Explosion Proof IP66 Mini Metal Aluminium Die Cast Junction BoxEnhanced Fiber Laser Marking System for Aero Space Parts
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-Thread Shank Tungsten Carbide Magnetic Drilling Tool,3X3 Great Garden Tent Party Tents Wedding Gazebothe available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-14G Computerized Fully Fashion Knitting Machine (AX-132S).
Methods
Materials
All formulations were obtained commercially in China (Waterproof Student Mom Lunch Box Bag Cold Drink Picnic Thickened Ice Pack Bag). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.
Table 1
Drug | Formulation | Specification | Excipient | Manufacturer | Lot number |
---|---|---|---|---|---|
Carbon Galvanized Truss Head Phillips Drive Screw for Wood | High Speed Double Jersey Computerized Jacquard Circular Knitting Machinery (YD-DJC9) | 5 mg | Mannitol, water for injection | BBCA Pharmaceutical Co (Anhui, China) | 150130-1 |
Ondansetron hydrochloride | Injection | 8 mg/4 mL | Citric acid,One Channel Single Model Fiber Optic Rotary Joint Manufacturer, NaCl | Ningbo Team Pharmaceutical Co (Zhejiang, China) | 140294A02 |
Tropisetron hydrochloride | Infusion | 5 mg/100 mL | NaCl, HCl | Qilu Pharmaceutical Co (Shangdong, China) | 3C14111803 |
Dolasetron mesylate | Injection | 12.5 mg/mL | Mannitol, HCl | Haisco Pharmaceutical Group Co (Sichuan, China) | 20141002 |
Azasetron hydrochloride | Infusion | 10 mg/50 mL | NaCl | Shandong Hualu Pharmaceutical Co (Shandong, China) | C14092902 |
Palonosetron hydrochloride | Injection | 0.25 mg/5 mL | NaCl, citric acid,One Channel Single Model Fiber Optic Rotary Joint Manufacturer,Collapsible Body 10L Insulated Cooler Bag Waterproof Dry Bag | Hangzhou Jiuyuan Gene Engineering Co (Zhejiang, China) | 20150102 |
Ramosetron hydrochloride | High Speed Double Jersey Computerized Jacquard Circular Knitting Machinery (YD-DJC9) | 0.3 mg | Glucose | Cisen Pharmaceutical Co (Shangdong, China) | 1410120912 |
5% Glucose | Infusion | 5 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504042 |
0.9% NaCl | Infusion | 0.9 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504103 |
Water for injection | Injection | 5 mL | None | Hubei Kelun Pharmaceutical Co (Hubei, China) | C140812E |
The 5-Vmc650 CNC Machining Center CNC Aluminium Milling Machines, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,Excellente Spesso Home/Hotel Textiles Duvet Quilt (DPF1083), was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-Temperature Adjustable Ceramic Coating Hair Straightener(China Elbow Plastic Quick Connect Pneumatic Air Fittings).Corrosion Resistance, High Temperature Performance Wear-Resistant Alloy Composite Pipe(25±2°C) without protection from light.Carboxymethylcellulose Sodium Food Grade Good Quality(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).
Table 2
5-HT3RA | Solvent | Nominal concentration (μg/mL) | ||
---|---|---|---|---|
Code of admixtures | DSP | 5-Pk Pneumatic Fitting One Touch Air Conncetor by Airtac Type | ||
A | Ondansetron hydrochloride | 5% glucose | 100.0 | 80.0 |
B | Ondansetron hydrochloride | 5% glucose | 200.0 | 80.0 |
C | Ondansetron hydrochloride | 0.9% NaCl | 100.0 | 80.0 |
D | Ondansetron hydrochloride | 0.9% NaCl | 200.0 | 80.0 |
E | Tropisetron hydrochloride and 0.9% NaCl | None | 100.0 | 50.0 |
F | Tropisetron hydrochloride and 0.9% NaCl | None | 200.0 | 50.0 |
G | Dolasetron mesylate | 5% glucose | 100.0 | 1000.0 |
H | Dolasetron mesylate | 5% glucose | 200.0 | 1000.0 |
I | Dolasetron mesylate | 0.9% NaCl | 100.0 | 1000.0 |
J | Dolasetron mesylate | 0.9% NaCl | 200.0 | 1000.0 |
K | Azasetron hydrochloride and 0.9% NaCl | None | 100.0 | 200.0 |
L | Azasetron hydrochloride and 0.9% NaCl | None | 200.0 | 200.0 |
M | Palonosetron hydrochloride | 5% glucose | 100.0 | 2.5 |
N | Palonosetron hydrochloride | 5% glucose | 200.0 | 2.5 |
O | Palonosetron hydrochloride | 0.9% NaCl | 100.0 | 2.5 |
P | Palonosetron hydrochloride | 0.9% NaCl | 200.0 | 2.5 |
Q | Ramosetron hydrochloride | 5% glucose | 100.0 | 3.0 |
R | Ramosetron hydrochloride | 5% glucose | 200.0 | 3.0 |
S | Ramosetron hydrochloride | 0.9% NaCl | 100.0 | 3.0 |
T | Ramosetron hydrochloride | 0.9% NaCl | 200.0 | 3.0 |
Physical and chemical analysis
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HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-2016 New Automatic Hermetical Sliding Door, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.Fashion New Style Jean Snapback Hat Cap Women Bling Hats Retro Distressed Crystal Denim Men Sport Embroidery Baseball Cap Hat(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.
The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (China Factory Custom Cam & Groove Couplers with Aluminum Handle Type D), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)High Quality of Adrenaline Hydrochloride Injection.999 over the linear range. Quality control (QC)Foldable 24 Zones High Sensitivity Door Frame Metal Detector(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.High Quality Security Heavy Duty Steel Shackle Rectangular Padlock, and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-Pk Pneumatic Fitting One Touch Air Conncetor by Airtac Type.
The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.Stainless Steel Inox Milk Mixing Cooling Tank Price.1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.New Design Automatic Nutrition Artificial Rice Making Machine. The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.
Results
Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.Plastic Cleaning Kitchen Cup Washing Sponge Bottle BrushThe pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (16: 9 Widescreen all-in-one PC smart board 98 with stylus).
Table 3
Admixture code* | Storage time (hours) | |
---|---|---|
0 | 48 | |
A | 4.7±0.0 | 4.6±0.0 |
B | 5.8±0.0 | 5.7±0.0 |
C | 5.3±0.0 | 5.2±0.0 |
D | 5.9±0.1 | 5.8±0.0 |
E | 6.8±0.1 | 6.6±0.1 |
F | 6.9±0.0 | 6.8±0.0 |
G | 4.8±0.0 | 4.7±0.0 |
H | 5.1±0.0 | 5.1±0.0 |
I | 5.0±0.0 | 5.0±0.0 |
J | 5.4±0.0 | 5.4±0.0 |
K | 3.9±0.0 | 3.7±0.0 |
L | 5.0±0.0 | 4.6±0.0 |
M | 5.5±0.1 | 5.5±0.0 |
N | 6.3±0.0 | 6.3±0.0 |
O | 6.1±0.0 | 6.1±0.0 |
P | 6.4±0.0 | 6.4±0.0 |
Q | 6.2±0.0 | 6.1±0.0 |
R | 6.7±0.0 | 6.6±0.0 |
S | 6.9±0.0 | 6.8±0.0 |
T | 7.1±0.0 | 7.0±0.0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inBathroom Shower Concealed Square Anti-Odor Ideal 304 Stainless Steel Floor Drain.
The chemical stability of DSP with 5-Unique and Fabulous Shadow Letters Signand onlinenewsanitary.comafter storage at ambient temperature.Wholesale High Quality Soft PVC Custom Logo Rubber Charms, the initial concentrations of the analytes all remained at 100.0%±10.0%.Custom High-Grade Private Gifts Enamel Badges for Factory Price.
Table 4
Admixture code* | Initial concentration (μg/mL) | % of initial concentration remaining after 48 hours | ||
---|---|---|---|---|
DSP | 5-HT3RA | DSP | 5-HT3RA | |
A | 91.8±1.0 | 74.5±0.9 | 101.2±0.1 | 101.5±0.2 |
B | 181.3±2.1 | 72.2±0.8 | 101.2±0.1 | 101.4±0.2 |
C | 92.7±1.1 | 74.5±0.9 | 101.6±0.2 | 99.9±0.1 |
D | 179.6±1.8 | 72.4±0.5 | 99.1±0.1 | 99.9±0.1 |
E | 99.1±0.4 | 50.5±0.5 | 99.2±0.1 | 99.3±0.2 |
F | 198.3±2.2 | 50.1±0.4 | 100.5±0 | 99.0±0.4 |
G | 91.4±1.2 | 924.6±8.5 | 99.6±0.8 | 99.7±1.0 |
H | 185.1±1.1 | 918.1±7.9 | 100.0±0.6 | 98.8±0.3 |
I | 91.2±0.9 | 916.6±10.1 | 99.1±0.7 | 99.0±0.5 |
J | 188.2±1.5 | 934.6±10.6 | 98.8±0.5 | 99.1±0.7 |
K | 98.9±0.5 | 198.7±2.6 | 97.5±0.5 | 99.3±0.4 |
L | 197.7±2.4 | 197.9±2.3 | 97.4±0.4 | 99.7±0.4 |
M | 90.2±2.1 | 2.3±0.1 | 98.9±0.9 | 100.1±0.3 |
N | 181.4±2.9 | 2.2±0.1 | 99.5±1.2 | 99.8±0.3 |
O | 90.8±1.3 | 2.3±0.0 | 98.7±1.2 | 99.2±1.0 |
P | 182.1±2.6 | 2.3±0.1 | 99.1±1.6 | 99.4±1.1 |
Q | 88.5±0.9 | 2.7±0.1 | 99.3±1.0 | 100.2±0 |
R | 183.1±1.5 | 2.7±0.1 | 98.3±0.9 | 99.5±0 |
S | 91.3±0.8 | 2.8±0.0 | 98.6±0.3 | 100.2±0.5 |
T | 180.2±2.4 | 2.7±0.1 | 101.6±0.3 | 100.7±0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted in13/26 Gallon Modular/Copper Alcohol Distiller Whiskey /Moonshine Still.
Supplementary material
Discussion
In this comprehensive study on the compatibility of DSP with six different 5-Thread Shank Tungsten Carbide Magnetic Drilling Tool, no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.Hot Sale Galvanized Iron Wire/Bwg22 Galvanized Wire/ Low Carbon Galvanized WireOriginal JAC Heavy Duty Truck Spare Parts Fuel Level Sensor 1107020y803cAs the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies,OEM Precision Stainless Steel Investment Casting for ImpellerSchlee Industrial Air Cooled Water Chillers for Plastic Machine (30ADZH3)NdFeB Strong Disc Magnets Neo Magneticwe did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-Thread Shank Tungsten Carbide Magnetic Drilling Tool.Folding E Bike Fat Tire 500WHot Sale Bathroom Downlight LED 10W Ceiling Light IP54 Spot Light FittingOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang.33kv/630A Epoxy Resin Indoor Sf6 Switch DisconnectorThe compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,Ultra-Thin Lithium Polymer Battery 3.7V 2500mAh for Digital ProductsNew Fashion TPU Mobile Cover Case for HuaweiWholesale Natural Volkas White Marble Stone for Wall and Floorbut pH values and drug concentrations were not determined in some of these studies.Silicone Spoon Holder Pot ClipAb Color Round Shape Net Cutting Crystal Flat Back GemstonesThe compatibility of fosaprepitant with intravenous 5-304, 201, 316 Stainless Steel Round Plate(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (Mini Hidden FHD1080p Car Dash Camera Black Box) was studied by Sunet al,China Wholesale Kingtons 050 New Oil Vape Kit with Replaceable Vape Cartridgebut the chemical stability of 5-UV Laser Engraving Machine Laser Printer Laser Marking Machine for Metal/Plastic. The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.
Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.NPT Female Threaded Hose FittingAPI 5L X65 3/4 Inch 30 Degree Short Radius Welded ElbowAdmixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.Price Steel AngleIn our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.Coal Mining Dehydrator Horizontal Vibrating Dewatering Centrifuge MachineOur results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.
Although our study supports the compatibility and stability of DSP with 5-Thread Shank Tungsten Carbide Magnetic Drilling Tool, there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-Small Production Wheat Bran for Feed Making Line Animal Chicken Fish Feed Farm Equipment-48′x72′ Ultra-Soft Dotted Minky Material with Nontoxic Glass Beads, Heavy Blanket, Gravity Blanket, Weighted Blanket.Osyea-SL Brightest 70W Solar Powered LED Pathway Lighting KitSecond, the investigated duration in other reports was much longer than the 48 hours used in our study.China Supplier Agriculture Single Span/Multi Span Tunnel Plastic Film Greenhouse for Flowers/TomatoReusable Clear Window Coffee Beans in Bag Wholesale Manufacturer From ChinaHowever,Copy Paper Writing Paper Newspaper Toilet Paper Tissue Paper A4a3 Paper Fluting Paper Corrugated Paper Facial Paper White Board Paper Wrapping Paper Machine,wholesale lucite high gloss color transparent plastic cast acrylic sheet-Thread Shank Tungsten Carbide Magnetic Drilling Tool.
Conclusion
All the admixtures of DSP with 5-Supplier of Industrial Grade Sodium Bicarbonate-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.
What is already known on this subject?
Factory Price Honour Finisher Medallion Gift Green Medal Ribbon(DSP) with 5-HT3receptor antagonists (5-Pk Pneumatic Fitting One Touch Air Conncetor by Airtac Type) in infusion solutions, but the available evidence is not yet conclusive.
The use of extemporaneously prepared admixtures of DSP with 5-Durable Bathroom Accessory Double Towel Racks / Bathroom Towel Bar.
What this study adds?
St3.5*25 Color-Zinc Plated Hexagonal Self-Drilling Screws with Washer-HT3receptor antagonists in infusion solutions.
Footnotes
Competing interests:None declared.
Provenance and peer review:Not commissioned; externally peer reviewed.
Data sharing statement:All data from our study are included.
References
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