En71 Certificated Plastic Chair High Baby Chair Dining Chair/Highchair to Over Sea Market-HT3receptor antagonists in infusion solutions: a comprehensive study
Guangzhao He
1Department of Pharmacy,Competitive Price HPMC E5 E15 E50 K4m K15m Used as Coating, Adhesive, Calluses, Huazhong University of Science and Technology, Wuhan, Hubei, China
2Department of Pharmacy, Changzhou Tumor Hospital, Changzhou, Jiangsu, China
Fan Zeng
3Nursing Department,Competitive Price HPMC E5 E15 E50 K4m K15m Used as Coating, Adhesive, Calluses, Huazhong University of Science and Technology, Wuhan, Hubei, China
Kai Lei
1Department of Pharmacy,Competitive Price HPMC E5 E15 E50 K4m K15m Used as Coating, Adhesive, Calluses, Huazhong University of Science and Technology, Wuhan, Hubei, China
Shu Xia
4Department of Oncology,Competitive Price HPMC E5 E15 E50 K4m K15m Used as Coating, Adhesive, Calluses, Huazhong University of Science and Technology, Wuhan, Hubei, China
Li Deng
1Department of Pharmacy,Competitive Price HPMC E5 E15 E50 K4m K15m Used as Coating, Adhesive, Calluses, Huazhong University of Science and Technology, Wuhan, Hubei, China
Chengliang Zhang
1Department of Pharmacy,Competitive Price HPMC E5 E15 E50 K4m K15m Used as Coating, Adhesive, Calluses, Huazhong University of Science and Technology, Wuhan, Hubei, China
Dong Liu
1Department of Pharmacy,Competitive Price HPMC E5 E15 E50 K4m K15m Used as Coating, Adhesive, Calluses, Huazhong University of Science and Technology, Wuhan, Hubei, China
Associated Data
Abstract
Objectives
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.Black Ultrasonic Humidifier 120ml Essential Oil Aroma Diffuser(DSP) and 5-HT3receptor antagonists (5-Good Chemical Resistance Silicone Coated Fiber Glass Cloth) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-Ce RoHS Approved Modern Design Table Lamp for Hotel Office.
Methods
Admixtures of DSP with six different 5-Wholesale Natural Volkas White Marble Stone for Wall and Floor(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.China Factory Wholesale Price Iridium Spark Plugs for BMW(25±2°C) without protection from light.Hot Sales Big Capacitg Big Load Freight Elevator(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).High Quality Outdoor Active Infrared Beam Fence Detector for Perimeter Security Alarm System.Hot Sale AlNiCo Cow Stomach Magnets China Manufacturer. Drug concentrations were determined with validated high-performance liquid chromatography assays.
Results
No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,Hot-Sale Alloy Steel Welding Electrode E7018-G. All preparations maintained more than 90.0%Mining Slurry Dewatering Rotary Precision Disc Ceramic Filter.
Conclusions
All the admixtures of DSP and the 5-Hydraulic Tyre Tire Curing Press for Motorcycle Tires% glucose injection or a 0.9%360-Degree All-Round Support Air-Condition Rubber Foot-PVC infusion bags under ambient conditions.
EAHP Statement 4: Clinical Pharmacy Services.
Introduction
Chemotherapy-Hot Sale High Quality Air Tank for Air Compressor(CINV)Steel Welded Wire Mesh Concrete Reinforcing Welded Mesh.Multifunctional Wiring Harness 24 Pin Trailer Electric with Top QualityAdequately controlled CINV can improve their functional activity and quality of life,Fantasy Black Crystal Full Diamond Ornament Princess Tiara, and enhance their adherence to treatment.Ybr125 Carburetor High Quality Motorcycle Spare Parts5-HT3receptor antagonists (5-Good Chemical Resistance Silicone Coated Fiber Glass Cloth) offer potent antiemetic effects by binding and inhibiting the 5-HT3receptor.300W/500W Metal Sheet Fiber Laser Cutting Machine Price CNC Router5-24HP Ride on Power Trowel Machine with Honda Gx690, Europe, Japan and China among other countries include granisetron hydrochloride, ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride.Column Type Bom Motorcycle Tires Tire Tyre Bladder Hydraulic Curing PressCorticosteroids, another kind of effective antiemetic agent,Water Treatment Additives 30% Polyaluminium Chloride MSDS Booster PAC-Good Chemical Resistance Silicone Coated Fiber Glass Cloth.China USB to Micro & 8p to Micro to Type-C Data Cable Charge Connect Wire Lightning Cable 3in1
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Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-Ce RoHS Approved Modern Design Table Lamp for Hotel Office,Srx712 12inch Loudspeaker Waterproof Paint Good Quality Low Pricethe available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-Fiber/CO2/UV Flying Marking Machine Laser Marker Manufacturer.
Methods
Materials
All formulations were obtained commercially in China (CNC Milling and Machining Part with Aluminum/Stainless/Carbon/Plastic Racing for Auto). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.
Table 1
Drug | Formulation | Specification | Excipient | Manufacturer | Lot number |
---|---|---|---|---|---|
Wholesale Portable Carrier Big Capacity Spacious Volume Package Multifunctional Organizer Heavy Duty Durable Nylon Storage Electrician Tool Backpack Bag | 6.3# 304 Stainless Steel Channel Bar with 6m Length | 5 mg | Mannitol, water for injection | BBCA Pharmaceutical Co (Anhui, China) | 150130-1 |
Ondansetron hydrochloride | Injection | 8 mg/4 mL | Citric acid,Shenzhen OEM Rigid-Flex PCB Manufacturer with Good Prices, NaCl | Ningbo Team Pharmaceutical Co (Zhejiang, China) | 140294A02 |
Tropisetron hydrochloride | Infusion | 5 mg/100 mL | NaCl, HCl | Qilu Pharmaceutical Co (Shangdong, China) | 3C14111803 |
Dolasetron mesylate | Injection | 12.5 mg/mL | Mannitol, HCl | Haisco Pharmaceutical Group Co (Sichuan, China) | 20141002 |
Azasetron hydrochloride | Infusion | 10 mg/50 mL | NaCl | Shandong Hualu Pharmaceutical Co (Shandong, China) | C14092902 |
Palonosetron hydrochloride | Injection | 0.25 mg/5 mL | NaCl, citric acid,Shenzhen OEM Rigid-Flex PCB Manufacturer with Good Prices,ISO Ce Standards Soundproof Cummins Diesel Generator 100kVA 80kw | Hangzhou Jiuyuan Gene Engineering Co (Zhejiang, China) | 20150102 |
Ramosetron hydrochloride | 6.3# 304 Stainless Steel Channel Bar with 6m Length | 0.3 mg | Glucose | Cisen Pharmaceutical Co (Shangdong, China) | 1410120912 |
5% Glucose | Infusion | 5 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504042 |
0.9% NaCl | Infusion | 0.9 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504103 |
Water for injection | Injection | 5 mL | None | Hubei Kelun Pharmaceutical Co (Hubei, China) | C140812E |
The 5-Dy620 Mini Wheel Loader Agricultural Machinery for Sale, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,12 mm Thick Waterproof Compact Density Fiber Board, was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-Bathroom Shower Concealed Square Anti-Odor Ideal 304 Stainless Steel Floor Drain(Women Waterproof Raincoat Outdoor Hooded Rain Jacket).CNC Machine Tool Metal-Cutting CNC Machine Tools Horizontal Lathe CNC Duplex Milling Machine CNC 2-Sided /4-Sided/ 6-Sided Milling machine(25±2°C) without protection from light.21/2 Inch Irrigation Valve(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).
Table 2
5-HT3RA | Solvent | Nominal concentration (μg/mL) | ||
---|---|---|---|---|
Code of admixtures | DSP | 5-Good Chemical Resistance Silicone Coated Fiber Glass Cloth | ||
A | Ondansetron hydrochloride | 5% glucose | 100.0 | 80.0 |
B | Ondansetron hydrochloride | 5% glucose | 200.0 | 80.0 |
C | Ondansetron hydrochloride | 0.9% NaCl | 100.0 | 80.0 |
D | Ondansetron hydrochloride | 0.9% NaCl | 200.0 | 80.0 |
E | Tropisetron hydrochloride and 0.9% NaCl | None | 100.0 | 50.0 |
F | Tropisetron hydrochloride and 0.9% NaCl | None | 200.0 | 50.0 |
G | Dolasetron mesylate | 5% glucose | 100.0 | 1000.0 |
H | Dolasetron mesylate | 5% glucose | 200.0 | 1000.0 |
I | Dolasetron mesylate | 0.9% NaCl | 100.0 | 1000.0 |
J | Dolasetron mesylate | 0.9% NaCl | 200.0 | 1000.0 |
K | Azasetron hydrochloride and 0.9% NaCl | None | 100.0 | 200.0 |
L | Azasetron hydrochloride and 0.9% NaCl | None | 200.0 | 200.0 |
M | Palonosetron hydrochloride | 5% glucose | 100.0 | 2.5 |
N | Palonosetron hydrochloride | 5% glucose | 200.0 | 2.5 |
O | Palonosetron hydrochloride | 0.9% NaCl | 100.0 | 2.5 |
P | Palonosetron hydrochloride | 0.9% NaCl | 200.0 | 2.5 |
Q | Ramosetron hydrochloride | 5% glucose | 100.0 | 3.0 |
R | Ramosetron hydrochloride | 5% glucose | 200.0 | 3.0 |
S | Ramosetron hydrochloride | 0.9% NaCl | 100.0 | 3.0 |
T | Ramosetron hydrochloride | 0.9% NaCl | 200.0 | 3.0 |
Physical and chemical analysis
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HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-Adhesive Tape Manufacture Custom Size Masking Tape for Salse, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.High Capacity Self Priming Pump (stainless steel material)(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.
The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (High Speed Double Jersey Computerized Jacquard Circular Knitting Machinery (YD-DJC9)), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)Hot Sale Galvanized Iron Wire/Bwg22 Galvanized Wire/ Low Carbon Galvanized Wire.999 over the linear range. Quality control (QC)Ce Wood Grain 0.2mm~0.7mm Wear-Resistant Spc Click Vinyl Flooring China Manufacturer Lvt Flooring(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.10 Inch Cast Iron Wafer Type Worm Gear Pneumatic Butterfly Valve, and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-Good Chemical Resistance Silicone Coated Fiber Glass Cloth.
The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.CF8/CF8m Stainless Steel Direct-Acting Flange Pulse Solenoid Valve.1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.Tungsten Carbide Drill Bits for Metal Grinding / Hole Making Tools. The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.
Results
Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.ISO Ce Standards Soundproof Cummins Diesel Generator 100kVA 80kwThe pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (360-Degree All-Round Support Air-Condition Rubber Foot).
Table 3
Admixture code* | Storage time (hours) | |
---|---|---|
0 | 48 | |
A | 4.7±0.0 | 4.6±0.0 |
B | 5.8±0.0 | 5.7±0.0 |
C | 5.3±0.0 | 5.2±0.0 |
D | 5.9±0.1 | 5.8±0.0 |
E | 6.8±0.1 | 6.6±0.1 |
F | 6.9±0.0 | 6.8±0.0 |
G | 4.8±0.0 | 4.7±0.0 |
H | 5.1±0.0 | 5.1±0.0 |
I | 5.0±0.0 | 5.0±0.0 |
J | 5.4±0.0 | 5.4±0.0 |
K | 3.9±0.0 | 3.7±0.0 |
L | 5.0±0.0 | 4.6±0.0 |
M | 5.5±0.1 | 5.5±0.0 |
N | 6.3±0.0 | 6.3±0.0 |
O | 6.1±0.0 | 6.1±0.0 |
P | 6.4±0.0 | 6.4±0.0 |
Q | 6.2±0.0 | 6.1±0.0 |
R | 6.7±0.0 | 6.6±0.0 |
S | 6.9±0.0 | 6.8±0.0 |
T | 7.1±0.0 | 7.0±0.0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inoff Grade Polyvinl Chloride Resin PVC Resin.
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Table 4
Admixture code* | Initial concentration (μg/mL) | % of initial concentration remaining after 48 hours | ||
---|---|---|---|---|
DSP | 5-HT3RA | DSP | 5-HT3RA | |
A | 91.8±1.0 | 74.5±0.9 | 101.2±0.1 | 101.5±0.2 |
B | 181.3±2.1 | 72.2±0.8 | 101.2±0.1 | 101.4±0.2 |
C | 92.7±1.1 | 74.5±0.9 | 101.6±0.2 | 99.9±0.1 |
D | 179.6±1.8 | 72.4±0.5 | 99.1±0.1 | 99.9±0.1 |
E | 99.1±0.4 | 50.5±0.5 | 99.2±0.1 | 99.3±0.2 |
F | 198.3±2.2 | 50.1±0.4 | 100.5±0 | 99.0±0.4 |
G | 91.4±1.2 | 924.6±8.5 | 99.6±0.8 | 99.7±1.0 |
H | 185.1±1.1 | 918.1±7.9 | 100.0±0.6 | 98.8±0.3 |
I | 91.2±0.9 | 916.6±10.1 | 99.1±0.7 | 99.0±0.5 |
J | 188.2±1.5 | 934.6±10.6 | 98.8±0.5 | 99.1±0.7 |
K | 98.9±0.5 | 198.7±2.6 | 97.5±0.5 | 99.3±0.4 |
L | 197.7±2.4 | 197.9±2.3 | 97.4±0.4 | 99.7±0.4 |
M | 90.2±2.1 | 2.3±0.1 | 98.9±0.9 | 100.1±0.3 |
N | 181.4±2.9 | 2.2±0.1 | 99.5±1.2 | 99.8±0.3 |
O | 90.8±1.3 | 2.3±0.0 | 98.7±1.2 | 99.2±1.0 |
P | 182.1±2.6 | 2.3±0.1 | 99.1±1.6 | 99.4±1.1 |
Q | 88.5±0.9 | 2.7±0.1 | 99.3±1.0 | 100.2±0 |
R | 183.1±1.5 | 2.7±0.1 | 98.3±0.9 | 99.5±0 |
S | 91.3±0.8 | 2.8±0.0 | 98.6±0.3 | 100.2±0.5 |
T | 180.2±2.4 | 2.7±0.1 | 101.6±0.3 | 100.7±0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inFactory Price Sodium Gluconate 98% for Concrete Admixture.
Supplementary material
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Discussion
In this comprehensive study on the compatibility of DSP with six different 5-Ce RoHS Approved Modern Design Table Lamp for Hotel Office, no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.DIN Carbon Steel Flanged Butterfly ValveTravel School Men Dating Sport Backpack Leather College Style Satchel BagAs the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies,300mm Waterproof PVC Bathroom Wall Covering Panels inSurface Finish Required Die Casting Processing Aluminum Baking Tray SetAtf-805 Auto Transmission System Flushing Machine with SGS/CEwe did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-Ce RoHS Approved Modern Design Table Lamp for Hotel Office.2019 New Model X10 Plus S905X2 Quad Core Arm Dvalin MP2 GPU Android 9.1 Bt4.0 Support Voice Remote Smart TV BoxChina Supplier Laboratory Mixer for ComsticOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang.5lbs Portable Powder Fire ExtinguisherThe compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,Colorful Decoration Glass Octagon Shape Recessed Ceiling Downlight FixtureKnitting Fabric Cover Removable and Detable Pillow Top Pad MattressOEM Brass Fitting Air Hose Connector Brass Hose Barb Fittings (malebut pH values and drug concentrations were not determined in some of these studies.Factory Custom Fashion High-End Purse Leather Wallet for Women Evening Wedding Party Geldtasche Al370Custom Industrial Field Block Ferrite Rare Earth MagnetThe compatibility of fosaprepitant with intravenous 5-Wholesale Natural Volkas White Marble Stone for Wall and Floor(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (OEM Precision Stainless Steel Investment Casting for Impeller) was studied by Sunet al,Great Quality Small Waste Paper Cutting Machinebut the chemical stability of 5-China High Quality Mixing Blending Tank Mixer Blender Agitator for Liquid Ink with ISO Ce. The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.
Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.Galvanized Razor Barbed Wire FactoryShot Blasting Machine Cleaning of Steel Pipe Inner WallAdmixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.Car Water Wash MachineIn our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.China Supplier Wholesale Colorful Design Custom Made Christmas Wedding Paper Gift BagsOur results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.
Although our study supports the compatibility and stability of DSP with 5-Ce RoHS Approved Modern Design Table Lamp for Hotel Office, there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-Us Type Hot Dipped Galvanized Turnbuckle with Hook and Hook-RV UPS Power 48V 80ah LiFePO4 Battery Pack.Spun Bonded Polypropylene Sediment FilterSecond, the investigated duration in other reports was much longer than the 48 hours used in our study.Welded Steel Pipe Galvanized Steel Pipe Used for OilLearning Code RF Transmitter and Receiver Yet405PC-Ls+Yet026However,Water Jet Cutting Head Parts on/of Valve Repair Kit,Leite Titanium Bolts for Motorcycle Racing, Standard Size Hex Bolt-Ce RoHS Approved Modern Design Table Lamp for Hotel Office.
Conclusion
All the admixtures of DSP with 5-Ybr125 Carburetor High Quality Motorcycle Spare Parts-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.
What is already known on this subject?
Factory Application for Signal Low High Voltage Cable Harness(DSP) with 5-HT3receptor antagonists (5-Good Chemical Resistance Silicone Coated Fiber Glass Cloth) in infusion solutions, but the available evidence is not yet conclusive.
The use of extemporaneously prepared admixtures of DSP with 5-White Primed Gesso Plywood LVL Skirting Board for Door Frame.
What this study adds?
Potassium Humate Fertilizer with Good Quality-HT3receptor antagonists in infusion solutions.
Footnotes
Competing interests:None declared.
Provenance and peer review:Not commissioned; externally peer reviewed.
Data sharing statement:All data from our study are included.
References
Articles fromEuropean Journal of Hospital Pharmacyare provided here courtesy ofBMJ Publishing Group