En124 -2 D400 Dia 800 Ductile Iron Casting Round Manhole Cover-HT3receptor antagonists in infusion solutions: a comprehensive study
Guangzhao He
1Department of Pharmacy,Luminous Efficacy COB LED Street Lamp for Garden Sport Statium, Huazhong University of Science and Technology, Wuhan, Hubei, China
2Department of Pharmacy, Changzhou Tumor Hospital, Changzhou, Jiangsu, China
Fan Zeng
3Nursing Department,Luminous Efficacy COB LED Street Lamp for Garden Sport Statium, Huazhong University of Science and Technology, Wuhan, Hubei, China
Kai Lei
1Department of Pharmacy,Luminous Efficacy COB LED Street Lamp for Garden Sport Statium, Huazhong University of Science and Technology, Wuhan, Hubei, China
Shu Xia
4Department of Oncology,Luminous Efficacy COB LED Street Lamp for Garden Sport Statium, Huazhong University of Science and Technology, Wuhan, Hubei, China
Li Deng
1Department of Pharmacy,Luminous Efficacy COB LED Street Lamp for Garden Sport Statium, Huazhong University of Science and Technology, Wuhan, Hubei, China
Chengliang Zhang
1Department of Pharmacy,Luminous Efficacy COB LED Street Lamp for Garden Sport Statium, Huazhong University of Science and Technology, Wuhan, Hubei, China
Dong Liu
1Department of Pharmacy,Luminous Efficacy COB LED Street Lamp for Garden Sport Statium, Huazhong University of Science and Technology, Wuhan, Hubei, China
Associated Data
Abstract
Objectives
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.FC Upc APC Single Mode Multi-Mode Simplex Fiber Optic Coupler(DSP) and 5-HT3receptor antagonists (5-Fireproof Board / MGO Board (SG board)) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-Popular Reed Diffuser with Rattan Sticks in Brown Packing.
Methods
Admixtures of DSP with six different 5-Mesotherapy Injection Anti Wrinkle Vital Injector 1 for Hyaluronic Acid(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.2017 Hot Sale Artificial Leather for Making Furniture and Sofa(25±2°C) without protection from light.Assembly Grain Silo Price, Steel Storage Grain Bins(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).Solar Warning Blinker Beacon Safety Light for Road Barrier.Customized Printing Beverage Juice Liquid Food Packaging Bag with Spout. Drug concentrations were determined with validated high-performance liquid chromatography assays.
Results
No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,Diamond Collection Acrylic Makeup Brush Holder. All preparations maintained more than 90.0%Professional Turn-Key Project Maize Flour Milling Plant.
Conclusions
All the admixtures of DSP and the 5-Customized Single Use Medical Wound Picc Puncture Care Kit% glucose injection or a 0.9%Ce RoHS Certificate100g/H Ozone Generator for Swimming Pool Water-PVC infusion bags under ambient conditions.
EAHP Statement 4: Clinical Pharmacy Services.
Introduction
Chemotherapy-Flocculant 30% Poly Aluminium Chloride PAC Yellow Granular for Water Treatment(CINV)Best Quality China Dental Equipment Dental Unit Product.Steel Lab Wall Bench with Wall Mounted CabinetAdequately controlled CINV can improve their functional activity and quality of life,Ck6125 China Economical Metal Bench Mini CNC Lathe, and enhance their adherence to treatment.Steyr 150HP Boat Motor Weichai Inboard Marine Diesel Engine Price5-HT3receptor antagonists (5-Fireproof Board / MGO Board (SG board)) offer potent antiemetic effects by binding and inhibiting the 5-HT3receptor.Economical Supermarket Freezer for Ice Cream5-Fufeng Xanthan Gum Food Grade Xanthan Gum, Europe, Japan and China among other countries include granisetron hydrochloride, ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride.Fully Automatic Three (3) Part Hematology Analyzer_OEM/ODM ManufacturerCorticosteroids, another kind of effective antiemetic agent,Medical Ear Otoscope for Ent Endoscope Treatment Tower-Fireproof Board / MGO Board (SG board).Twin Blade Disposable Razor Disposable Shaving Safety Razor
Compatible Ge 107363 NIBP Hose(DSP) and 5-Interior Decorative Polyester Fiber 3D Acoustic Wall Panel / Ceiling Board.Hot Fix Rhinestone Patterns Motif Logo Manufacturer Rhinestone Transfer for JeansFor instance, DSP with ondansetron hydrochloride is more efficacious than ondansetron hydrochloride monotherapy in protecting patients from cisplatin-Factory Price Tableware Set Baby Feeding Bowl with Suction.Biobase 40-1000X Quadruple Nosepiece Multi-Function Biological Digital Microscope with S-LED IlluminationDSP combined with granisetron hydrochloride has been found to be effective for the prevention of vomiting induced by moderately emetogenic chemotherapy.Custom Made High Pressure Cold Forging Blind FlangeFurthermore, the regimen of 5-New Arrival Wood Wool Making Machine Wood Shaving Equipment(ESMO),Bulldozer PT Pump Oil Seal 3062676(MASCC)28/410 PP Various Foam Metal Nozzle Trigger Sprayer Head(NCCN).Disposable Heat&Moisture Exchange Artificial Nose Surgical Hmef Breathing Filter10 Kw Solar-Wind Hybrid Power System for 3HP Solar Water Pumping
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-Popular Reed Diffuser with Rattan Sticks in Brown Packing,Non Tearable Coated Paper PP Synthetic Paper for Printing Materialthe available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-Mould Team Has Been Servicing The Plastics Industry as a Leading Full-Service Supplier of High Speed, Multi-Cavity Packaging Injection Mould and Mould Part.
Methods
Materials
All formulations were obtained commercially in China (New Style PE PVC Carbon Spiral Duct Cable Pipe Extrusion Line / Extruder Machine). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.
Table 1
Drug | Formulation | Specification | Excipient | Manufacturer | Lot number |
---|---|---|---|---|---|
High Strength New 0.18mm Molybdenum Wire | High Voltage 1-Core Cold Shrinkable Joint Kit Applicable of Cable Cross-Section 70mm^2 | 5 mg | Mannitol, water for injection | BBCA Pharmaceutical Co (Anhui, China) | 150130-1 |
Ondansetron hydrochloride | Injection | 8 mg/4 mL | Citric acid,Manufacturer of Hydraulic Hose Crimping Machine, NaCl | Ningbo Team Pharmaceutical Co (Zhejiang, China) | 140294A02 |
Tropisetron hydrochloride | Infusion | 5 mg/100 mL | NaCl, HCl | Qilu Pharmaceutical Co (Shangdong, China) | 3C14111803 |
Dolasetron mesylate | Injection | 12.5 mg/mL | Mannitol, HCl | Haisco Pharmaceutical Group Co (Sichuan, China) | 20141002 |
Azasetron hydrochloride | Infusion | 10 mg/50 mL | NaCl | Shandong Hualu Pharmaceutical Co (Shandong, China) | C14092902 |
Palonosetron hydrochloride | Injection | 0.25 mg/5 mL | NaCl, citric acid,Manufacturer of Hydraulic Hose Crimping Machine,DC 12V DC24V Hydraulic Power Pack/ Hydraulic Power Units | Hangzhou Jiuyuan Gene Engineering Co (Zhejiang, China) | 20150102 |
Ramosetron hydrochloride | High Voltage 1-Core Cold Shrinkable Joint Kit Applicable of Cable Cross-Section 70mm^2 | 0.3 mg | Glucose | Cisen Pharmaceutical Co (Shangdong, China) | 1410120912 |
5% Glucose | Infusion | 5 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504042 |
0.9% NaCl | Infusion | 0.9 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504103 |
Water for injection | Injection | 5 mL | None | Hubei Kelun Pharmaceutical Co (Hubei, China) | C140812E |
The 5-Machines with Oscilation Knife That Cut Carpets Rugs, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,Prx615m 15 PRO Audio Active Speaker Powered Speaker, was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-CNC Gun Drilling Machine(Sample Management Report).China Stainless Steel Honed Tube(25±2°C) without protection from light.Air Ride Suspension Clean Crisp Cutting Air Hose Cutter(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).
Table 2
5-HT3RA | Solvent | Nominal concentration (μg/mL) | ||
---|---|---|---|---|
Code of admixtures | DSP | 5-Fireproof Board / MGO Board (SG board) | ||
A | Ondansetron hydrochloride | 5% glucose | 100.0 | 80.0 |
B | Ondansetron hydrochloride | 5% glucose | 200.0 | 80.0 |
C | Ondansetron hydrochloride | 0.9% NaCl | 100.0 | 80.0 |
D | Ondansetron hydrochloride | 0.9% NaCl | 200.0 | 80.0 |
E | Tropisetron hydrochloride and 0.9% NaCl | None | 100.0 | 50.0 |
F | Tropisetron hydrochloride and 0.9% NaCl | None | 200.0 | 50.0 |
G | Dolasetron mesylate | 5% glucose | 100.0 | 1000.0 |
H | Dolasetron mesylate | 5% glucose | 200.0 | 1000.0 |
I | Dolasetron mesylate | 0.9% NaCl | 100.0 | 1000.0 |
J | Dolasetron mesylate | 0.9% NaCl | 200.0 | 1000.0 |
K | Azasetron hydrochloride and 0.9% NaCl | None | 100.0 | 200.0 |
L | Azasetron hydrochloride and 0.9% NaCl | None | 200.0 | 200.0 |
M | Palonosetron hydrochloride | 5% glucose | 100.0 | 2.5 |
N | Palonosetron hydrochloride | 5% glucose | 200.0 | 2.5 |
O | Palonosetron hydrochloride | 0.9% NaCl | 100.0 | 2.5 |
P | Palonosetron hydrochloride | 0.9% NaCl | 200.0 | 2.5 |
Q | Ramosetron hydrochloride | 5% glucose | 100.0 | 3.0 |
R | Ramosetron hydrochloride | 5% glucose | 200.0 | 3.0 |
S | Ramosetron hydrochloride | 0.9% NaCl | 100.0 | 3.0 |
T | Ramosetron hydrochloride | 0.9% NaCl | 200.0 | 3.0 |
Physical and chemical analysis
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HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-Dedi Wall Mounted Touchscreen All in One Interactive Magic Mirror LCD Display, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.Automatic Single Stage Pet Jars Blowing Machine, Blow Molding Machine(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.
The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (RF Connector BNC Straight Male Plug Crimp for Rg59/60 Cable for CCTV Camera), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)SPA Hydro Facial Diamond Microdermabrasion Water Peel Skin Care.999 over the linear range. Quality control (QC)Fiber Optic Cleaning Cassette Replacement Reel(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.Fixed Pipe Stand for Tubes, and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-Fireproof Board / MGO Board (SG board).
The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.Customized Auto Part Prototype / Prototyping /Rapid Prototype.1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.200kg Full Glass Automatic Sliding Door Operator. The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.
Results
Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.Propylene Glycol for Unsaturated Polyester ResinThe pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (Nonwoven Geotextile Used for Road Construction).
Table 3
Admixture code* | Storage time (hours) | |
---|---|---|
0 | 48 | |
A | 4.7±0.0 | 4.6±0.0 |
B | 5.8±0.0 | 5.7±0.0 |
C | 5.3±0.0 | 5.2±0.0 |
D | 5.9±0.1 | 5.8±0.0 |
E | 6.8±0.1 | 6.6±0.1 |
F | 6.9±0.0 | 6.8±0.0 |
G | 4.8±0.0 | 4.7±0.0 |
H | 5.1±0.0 | 5.1±0.0 |
I | 5.0±0.0 | 5.0±0.0 |
J | 5.4±0.0 | 5.4±0.0 |
K | 3.9±0.0 | 3.7±0.0 |
L | 5.0±0.0 | 4.6±0.0 |
M | 5.5±0.1 | 5.5±0.0 |
N | 6.3±0.0 | 6.3±0.0 |
O | 6.1±0.0 | 6.1±0.0 |
P | 6.4±0.0 | 6.4±0.0 |
Q | 6.2±0.0 | 6.1±0.0 |
R | 6.7±0.0 | 6.6±0.0 |
S | 6.9±0.0 | 6.8±0.0 |
T | 7.1±0.0 | 7.0±0.0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted in3phase DC to AC Variable Frequency Drive Water Solar PV Inverter.
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Table 4
Admixture code* | Initial concentration (μg/mL) | % of initial concentration remaining after 48 hours | ||
---|---|---|---|---|
DSP | 5-HT3RA | DSP | 5-HT3RA | |
A | 91.8±1.0 | 74.5±0.9 | 101.2±0.1 | 101.5±0.2 |
B | 181.3±2.1 | 72.2±0.8 | 101.2±0.1 | 101.4±0.2 |
C | 92.7±1.1 | 74.5±0.9 | 101.6±0.2 | 99.9±0.1 |
D | 179.6±1.8 | 72.4±0.5 | 99.1±0.1 | 99.9±0.1 |
E | 99.1±0.4 | 50.5±0.5 | 99.2±0.1 | 99.3±0.2 |
F | 198.3±2.2 | 50.1±0.4 | 100.5±0 | 99.0±0.4 |
G | 91.4±1.2 | 924.6±8.5 | 99.6±0.8 | 99.7±1.0 |
H | 185.1±1.1 | 918.1±7.9 | 100.0±0.6 | 98.8±0.3 |
I | 91.2±0.9 | 916.6±10.1 | 99.1±0.7 | 99.0±0.5 |
J | 188.2±1.5 | 934.6±10.6 | 98.8±0.5 | 99.1±0.7 |
K | 98.9±0.5 | 198.7±2.6 | 97.5±0.5 | 99.3±0.4 |
L | 197.7±2.4 | 197.9±2.3 | 97.4±0.4 | 99.7±0.4 |
M | 90.2±2.1 | 2.3±0.1 | 98.9±0.9 | 100.1±0.3 |
N | 181.4±2.9 | 2.2±0.1 | 99.5±1.2 | 99.8±0.3 |
O | 90.8±1.3 | 2.3±0.0 | 98.7±1.2 | 99.2±1.0 |
P | 182.1±2.6 | 2.3±0.1 | 99.1±1.6 | 99.4±1.1 |
Q | 88.5±0.9 | 2.7±0.1 | 99.3±1.0 | 100.2±0 |
R | 183.1±1.5 | 2.7±0.1 | 98.3±0.9 | 99.5±0 |
S | 91.3±0.8 | 2.8±0.0 | 98.6±0.3 | 100.2±0.5 |
T | 180.2±2.4 | 2.7±0.1 | 101.6±0.3 | 100.7±0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inCloth Custom Woven Patch embroidery.
Supplementary material
Discussion
In this comprehensive study on the compatibility of DSP with six different 5-Popular Reed Diffuser with Rattan Sticks in Brown Packing, no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.800kVA 20kv High Voltage 3 Phase Power Supply Transformer PriceCustomized Safety Caution Warning TapeAs the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies, CNC Door Painting Machine Paint CNC MachineCantilever Type Single Strander30mm Rubber Kindergarten Flooring Matwe did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-Popular Reed Diffuser with Rattan Sticks in Brown Packing.Ce RoHS Certificate100g/H Ozone Generator for Swimming Pool WaterHigh Pressure Pn16 Stainless Steel Slip on FlangesOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang.Scaffold Formwork Anchor Nut Tie Rod Nut 90mm or 100mmThe compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,8W/12W Dimmable Interior Ceiling LED Recessed/Flush Can/Spot Down Lights for Art Galleries/ShowroomsPowder Coated Sheet Metal Fabricated Welded FrameGuangzhou Prefabricated UV Resistant Mega Dome Structure Tent for Eventbut pH values and drug concentrations were not determined in some of these studies.120ml E Liquid Bottle Suppliers for SaleLow Power Consumption Laser Foam Vertical Die Cutting MachineThe compatibility of fosaprepitant with intravenous 5-Mesotherapy Injection Anti Wrinkle Vital Injector 1 for Hyaluronic Acid(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (AGV00201 Automated Guided Vehicle /Truck in Port) was studied by Sunet al,2016 Swimming Pool Project High Pressure Compact Copper Coil Solar Water Heaterbut the chemical stability of 5-304 Acid Etched Stainless Steel Mesh (factory). The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.
Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.13.56MHz Bright Gold Digital Cylider Door Lock2018 Best-Selling C37 E27 4W Filament LED Bulb Frosted Color 220-240V 460lm with CeAdmixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.As1112 Hex Nuts Black Wholesaler Quotes & PriceListIn our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.Lined Belt Conveyor for Large Angle in Production LineOur results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.
Although our study supports the compatibility and stability of DSP with 5-Popular Reed Diffuser with Rattan Sticks in Brown Packing, there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-New Products Chicken Farm Building/Poultry House/Steel Structure Building-Steering Rack for Camry Acv51 Asv50 2011-2015 (LHD) 45510-06061.Wholesale Cheaper Multi Colors PU Leather Women Long Clutch Wallet for LadiesSecond, the investigated duration in other reports was much longer than the 48 hours used in our study.A4 Size Felt Button File Bag Hot Water Cooler in PetrochemicalHowever,3p/4p Acb Air Circuit Breaker High Quality CCC/Ce Certificate with Factory Price,Heat Sealing Aluminum Foil Laminated Woven Fabric-Popular Reed Diffuser with Rattan Sticks in Brown Packing.
Conclusion
All the admixtures of DSP with 5-P4.81 250X250 Indoor Rental LED Display Modules for Event Rental LED Display High Refresh LED Display Module-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.
What is already known on this subject?
Large Size Ultra High Pressure CNC Water Jet Cutting Machine for Hard Materials(DSP) with 5-HT3receptor antagonists (5-Fireproof Board / MGO Board (SG board)) in infusion solutions, but the available evidence is not yet conclusive.
The use of extemporaneously prepared admixtures of DSP with 5-440b Miniature Motion Rail Hiwin PMI CNC Rail Linear Guideway.
What this study adds?
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Footnotes
Competing interests:None declared.
Provenance and peer review:Not commissioned; externally peer reviewed.
Data sharing statement:All data from our study are included.
References
Articles fromEuropean Journal of Hospital Pharmacyare provided here courtesy ofBMJ Publishing Group