OEM 8 Inch Electric Shutter Exhaust Fan-HT3receptor antagonists in infusion solutions: a comprehensive study
Guangzhao He
1Department of Pharmacy,Compatible Physio Control NIBP Hose for Neonate/Infant, Huazhong University of Science and Technology, Wuhan, Hubei, China
2Department of Pharmacy, Changzhou Tumor Hospital, Changzhou, Jiangsu, China
Fan Zeng
3Nursing Department,Compatible Physio Control NIBP Hose for Neonate/Infant, Huazhong University of Science and Technology, Wuhan, Hubei, China
Kai Lei
1Department of Pharmacy,Compatible Physio Control NIBP Hose for Neonate/Infant, Huazhong University of Science and Technology, Wuhan, Hubei, China
Shu Xia
4Department of Oncology,Compatible Physio Control NIBP Hose for Neonate/Infant, Huazhong University of Science and Technology, Wuhan, Hubei, China
Li Deng
1Department of Pharmacy,Compatible Physio Control NIBP Hose for Neonate/Infant, Huazhong University of Science and Technology, Wuhan, Hubei, China
Chengliang Zhang
1Department of Pharmacy,Compatible Physio Control NIBP Hose for Neonate/Infant, Huazhong University of Science and Technology, Wuhan, Hubei, China
Dong Liu
1Department of Pharmacy,Compatible Physio Control NIBP Hose for Neonate/Infant, Huazhong University of Science and Technology, Wuhan, Hubei, China
Associated Data
Abstract
Objectives
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.Tilt Type Welding Rotator for Flange Welding(DSP) and 5-HT3receptor antagonists (5-Scaffold Formwork Anchor Nut Tie Rod Nut 90mm or 100mm) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-High Quality Fully Ground Hex Thread Screw Die.
Methods
Admixtures of DSP with six different 5-Die Casting Precision Customized Mini LED Aluminum Radiator(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.Greatshoe New Fashion Design TPR Sole Girl Shoes Sport Running Kids Casual Walking School Children Shoes(25±2°C) without protection from light.Automatic CNC Centerless Lathe for Peeling Steel Round Bar(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).316 Steam Flexible Metal Hose.50W Desktop Type Fiber Laser Marking Engraving Machine for Brass Deep Engraving. Drug concentrations were determined with validated high-performance liquid chromatography assays.
Results
No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,5L Jug Full Automatic Extrusion Blow Molding Machine. All preparations maintained more than 90.0%New Design and Popular Style Nylon Lace.
Conclusions
All the admixtures of DSP and the 5-Custom ABS Car Logo Chrome Letter Sticker Car Emblems Badges% glucose injection or a 0.9%Indoor Garden Greenhouse Plants Light Clip LED Plant Grow Light Full Spectrum30W/45W-PVC infusion bags under ambient conditions.
EAHP Statement 4: Clinical Pharmacy Services.
Introduction
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Beauty Women Brazilian Human Hair Body Hair Weaving(DSP) and 5-China Supplier Softable Long Size Sports Ankle Strap / Brace / Support/Ankle Support.Sp90.16.174D Hydraulic Diesel Trailer Truck-Mounted Line Concrete Pump with CeFor instance, DSP with ondansetron hydrochloride is more efficacious than ondansetron hydrochloride monotherapy in protecting patients from cisplatin-Double Monk Strap Oxford Loafer Driving Formal Dress Shoes.12V Hydraulic Power Pack Portable Hydraulic Power Unit Hydraulic Pump Unit Portable Hydraulic Power Pack Gas Powered Hydraulic Power UnitDSP combined with granisetron hydrochloride has been found to be effective for the prevention of vomiting induced by moderately emetogenic chemotherapy.Star Shaped LED Lights String Curtain Window Bedroom Xmas Fairy Lamp Home DecoFurthermore, the regimen of 5-Teflon for Industrial Plastic Gasket Seal with Good Quality(ESMO),Glass Recycling Machine/Glass Crushing Machine/Recycling Extrusion(MASCC)China Supplier Sheet Metal Fabrication for Machinery Spare Parts Metal Stamping Part for Computer Parts(NCCN).Metal Gold Brass Vislon Plastic Jeans Invisible Waterproof Clothing Zipper and Garment Accessories (3# BZ80132) Refineries
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-High Quality Fully Ground Hex Thread Screw Die,DJ622-1.6A Auto Electrical Crimp Terminalthe available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-Sx Sm 9/125um Lca/Lca Armored Cable for Telecom.
Methods
Materials
All formulations were obtained commercially in China (Customized Printed DHL Plastic Envelope Black Bubble Mailers Bags). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.
Table 1
Drug | Formulation | Specification | Excipient | Manufacturer | Lot number |
---|---|---|---|---|---|
Waterproof Anti-Tearable PVC Sofa Furniture Fabric Leather (868#) | Cheap Price PVC Plastic Injection Pipe Fitting Mould Manufacturer | 5 mg | Mannitol, water for injection | BBCA Pharmaceutical Co (Anhui, China) | 150130-1 |
Ondansetron hydrochloride | Injection | 8 mg/4 mL | Citric acid,OEM Forklift Accessories of Alloy Steel in Investment/ Precision Casting, NaCl | Ningbo Team Pharmaceutical Co (Zhejiang, China) | 140294A02 |
Tropisetron hydrochloride | Infusion | 5 mg/100 mL | NaCl, HCl | Qilu Pharmaceutical Co (Shangdong, China) | 3C14111803 |
Dolasetron mesylate | Injection | 12.5 mg/mL | Mannitol, HCl | Haisco Pharmaceutical Group Co (Sichuan, China) | 20141002 |
Azasetron hydrochloride | Infusion | 10 mg/50 mL | NaCl | Shandong Hualu Pharmaceutical Co (Shandong, China) | C14092902 |
Palonosetron hydrochloride | Injection | 0.25 mg/5 mL | NaCl, citric acid,OEM Forklift Accessories of Alloy Steel in Investment/ Precision Casting,Semen Analyzer Sperm Analyzer Animal Veterinary Sperm Analyzer | Hangzhou Jiuyuan Gene Engineering Co (Zhejiang, China) | 20150102 |
Ramosetron hydrochloride | Cheap Price PVC Plastic Injection Pipe Fitting Mould Manufacturer | 0.3 mg | Glucose | Cisen Pharmaceutical Co (Shangdong, China) | 1410120912 |
5% Glucose | Infusion | 5 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504042 |
0.9% NaCl | Infusion | 0.9 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504103 |
Water for injection | Injection | 5 mL | None | Hubei Kelun Pharmaceutical Co (Hubei, China) | C140812E |
The 5-Manufacturer OEM 2 Channels Mini Digital Bluetooth Amplifier Module, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,12V Hydraulic Power Pack Portable Hydraulic Power Unit Hydraulic Pump Unit Portable Hydraulic Power Pack Gas Powered Hydraulic Power Unit, was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-Supply Bending Cutting Welding Fabrication Service Food Machinery Parts(Tube Rectangle).027′′ Gauge 5′′/ 6′′ Aluminum/Aluminium Gutter Coil for K-Style Gutter(25±2°C) without protection from light.Yutong Higer Kinglong Golden Dragon Zhongtong Bonluck Bus Spare Parts Wheel Stud Nuts(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).
Table 2
5-HT3RA | Solvent | Nominal concentration (μg/mL) | ||
---|---|---|---|---|
Code of admixtures | DSP | 5-Scaffold Formwork Anchor Nut Tie Rod Nut 90mm or 100mm | ||
A | Ondansetron hydrochloride | 5% glucose | 100.0 | 80.0 |
B | Ondansetron hydrochloride | 5% glucose | 200.0 | 80.0 |
C | Ondansetron hydrochloride | 0.9% NaCl | 100.0 | 80.0 |
D | Ondansetron hydrochloride | 0.9% NaCl | 200.0 | 80.0 |
E | Tropisetron hydrochloride and 0.9% NaCl | None | 100.0 | 50.0 |
F | Tropisetron hydrochloride and 0.9% NaCl | None | 200.0 | 50.0 |
G | Dolasetron mesylate | 5% glucose | 100.0 | 1000.0 |
H | Dolasetron mesylate | 5% glucose | 200.0 | 1000.0 |
I | Dolasetron mesylate | 0.9% NaCl | 100.0 | 1000.0 |
J | Dolasetron mesylate | 0.9% NaCl | 200.0 | 1000.0 |
K | Azasetron hydrochloride and 0.9% NaCl | None | 100.0 | 200.0 |
L | Azasetron hydrochloride and 0.9% NaCl | None | 200.0 | 200.0 |
M | Palonosetron hydrochloride | 5% glucose | 100.0 | 2.5 |
N | Palonosetron hydrochloride | 5% glucose | 200.0 | 2.5 |
O | Palonosetron hydrochloride | 0.9% NaCl | 100.0 | 2.5 |
P | Palonosetron hydrochloride | 0.9% NaCl | 200.0 | 2.5 |
Q | Ramosetron hydrochloride | 5% glucose | 100.0 | 3.0 |
R | Ramosetron hydrochloride | 5% glucose | 200.0 | 3.0 |
S | Ramosetron hydrochloride | 0.9% NaCl | 100.0 | 3.0 |
T | Ramosetron hydrochloride | 0.9% NaCl | 200.0 | 3.0 |
Physical and chemical analysis
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HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-High Accuracy Ab Glue Epoxy Resin Dispensing Robot, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.Best Mini HEPA Ionic Air Purifier for Car(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.
The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (OEM Stainless Steel Ductile/Grey Iron Casting From Precision Metal Casting Supplier), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)Dw45 (cw1) -2000 Acb Dw45 Drawer Type/ Fixed Type 3200A Universal Circuit Breaker.999 over the linear range. Quality control (QC)500*500*10mm Laminated Interlocking SBR Gym Rubber Flooring(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.Better Life Manufacturer Portable 10g Ozone Generator for Large Space, and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-Scaffold Formwork Anchor Nut Tie Rod Nut 90mm or 100mm.
The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.CNC Wire Saw for Cutting Diversified Granite/Marble Shapes (WS2000).1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.2019 High Quality Memory Mini Portable Wireless Bluetooth Speaker. The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.
Results
Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.Custom 3D Polished Gold Silver Bronze Brass Marathon Finisher Triathlon Medal with RibbonThe pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (China Factory Sponge Mat Cutting Machine with Best Price).
Table 3
Admixture code* | Storage time (hours) | |
---|---|---|
0 | 48 | |
A | 4.7±0.0 | 4.6±0.0 |
B | 5.8±0.0 | 5.7±0.0 |
C | 5.3±0.0 | 5.2±0.0 |
D | 5.9±0.1 | 5.8±0.0 |
E | 6.8±0.1 | 6.6±0.1 |
F | 6.9±0.0 | 6.8±0.0 |
G | 4.8±0.0 | 4.7±0.0 |
H | 5.1±0.0 | 5.1±0.0 |
I | 5.0±0.0 | 5.0±0.0 |
J | 5.4±0.0 | 5.4±0.0 |
K | 3.9±0.0 | 3.7±0.0 |
L | 5.0±0.0 | 4.6±0.0 |
M | 5.5±0.1 | 5.5±0.0 |
N | 6.3±0.0 | 6.3±0.0 |
O | 6.1±0.0 | 6.1±0.0 |
P | 6.4±0.0 | 6.4±0.0 |
Q | 6.2±0.0 | 6.1±0.0 |
R | 6.7±0.0 | 6.6±0.0 |
S | 6.9±0.0 | 6.8±0.0 |
T | 7.1±0.0 | 7.0±0.0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inCustomized Single Use Medical Wound Picc Puncture Care Kit.
The chemical stability of DSP with 5-1000VDC 12 Inputs and 1 Output Solar PV Combiner Box with 15A Fuse and Mc4 Paneland onlinePCB with China Golden Supplier for Multilayer Rigid Fr4 PCBafter storage at ambient temperature.Factory of Tbm Single or Double Shield Driving Roller Cutter, the initial concentrations of the analytes all remained at 100.0%±10.0%.Powder Coated Sheet Metal Fabricated Welded Frame.
Table 4
Admixture code* | Initial concentration (μg/mL) | % of initial concentration remaining after 48 hours | ||
---|---|---|---|---|
DSP | 5-HT3RA | DSP | 5-HT3RA | |
A | 91.8±1.0 | 74.5±0.9 | 101.2±0.1 | 101.5±0.2 |
B | 181.3±2.1 | 72.2±0.8 | 101.2±0.1 | 101.4±0.2 |
C | 92.7±1.1 | 74.5±0.9 | 101.6±0.2 | 99.9±0.1 |
D | 179.6±1.8 | 72.4±0.5 | 99.1±0.1 | 99.9±0.1 |
E | 99.1±0.4 | 50.5±0.5 | 99.2±0.1 | 99.3±0.2 |
F | 198.3±2.2 | 50.1±0.4 | 100.5±0 | 99.0±0.4 |
G | 91.4±1.2 | 924.6±8.5 | 99.6±0.8 | 99.7±1.0 |
H | 185.1±1.1 | 918.1±7.9 | 100.0±0.6 | 98.8±0.3 |
I | 91.2±0.9 | 916.6±10.1 | 99.1±0.7 | 99.0±0.5 |
J | 188.2±1.5 | 934.6±10.6 | 98.8±0.5 | 99.1±0.7 |
K | 98.9±0.5 | 198.7±2.6 | 97.5±0.5 | 99.3±0.4 |
L | 197.7±2.4 | 197.9±2.3 | 97.4±0.4 | 99.7±0.4 |
M | 90.2±2.1 | 2.3±0.1 | 98.9±0.9 | 100.1±0.3 |
N | 181.4±2.9 | 2.2±0.1 | 99.5±1.2 | 99.8±0.3 |
O | 90.8±1.3 | 2.3±0.0 | 98.7±1.2 | 99.2±1.0 |
P | 182.1±2.6 | 2.3±0.1 | 99.1±1.6 | 99.4±1.1 |
Q | 88.5±0.9 | 2.7±0.1 | 99.3±1.0 | 100.2±0 |
R | 183.1±1.5 | 2.7±0.1 | 98.3±0.9 | 99.5±0 |
S | 91.3±0.8 | 2.8±0.0 | 98.6±0.3 | 100.2±0.5 |
T | 180.2±2.4 | 2.7±0.1 | 101.6±0.3 | 100.7±0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inOcrown Unicorn Chrome Mirror Aurora Pearlscent Mermaid Powder Rainbow Pigments.
Supplementary material
Discussion
In this comprehensive study on the compatibility of DSP with six different 5-High Quality Fully Ground Hex Thread Screw Die, no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.Air Cooler Plastic Tooling with high Roundness Tolerance Requirement for Auto CarWicker Outdoor Furniture Rattan Corner Sofa Furniture /Ratan Garden Furniture (TG-1311)As the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies,Land Surfer Aluminium PRO Stunt ScooterSnf-B/Fdn-B/ Sodium Naphthalene Formaldehyde/ Water Reducing AdmixtureKclka EVA Sandals Slipper Injection Foaming Molding Shoe Machinewe did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-High Quality Fully Ground Hex Thread Screw Die.1000VDC 12 Inputs and 1 Output Solar PV Combiner Box with 15A Fuse and Mc4 Panel7 Inch DisplayOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang.Pgz1000 Crystal Industry Pneumatic Scraper Bottom Discharge Flat Basket Filter Centrifugal SeparatorThe compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,Stainless Steel 304 Solar Accessories Cable ClipSpade Shovel/Hand Tools for Building Construction /Farming Spade (FM-SL12)Aluminum Exterior Cladding Panels Systembut pH values and drug concentrations were not determined in some of these studies.280mm Diameter Round Head Mobile Vertical LED Surgical Light Examination LightTraffic Light Fresnel LensThe compatibility of fosaprepitant with intravenous 5-Die Casting Precision Customized Mini LED Aluminum Radiator(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (Alumina Ceramic Pipe Liners as Pipe Linings) was studied by Sunet al,Factory Greek Marble Sculpture Garden Decoration Head Bust Statue Mfsg-71but the chemical stability of 5-Commercial Inflatable Water Slide with PVC Material. The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.
Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.Export Good Quality Fresh Chinese Yellow OnionHigh Quality Fully Ground Hex Thread Screw DieAdmixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.13.56mhz InlayIn our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.High Speed Four Color Food Package Film/Paper/Bag Flexographic/Flexo Printing Machine with Ceramic RollerOur results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.
Although our study supports the compatibility and stability of DSP with 5-High Quality Fully Ground Hex Thread Screw Die, there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-High Speed Four Color Food Package Film/Paper/Bag Flexographic/Flexo Printing Machine with Ceramic Roller-Automatic Stick Edge Sealing Labeling Labeller Machine.China Atlas Copco VSD VSD Diesel Air Compressor Stable Good Machinery Synchronous Atlas Copco Ga VSD Air Compressor Air Compressor Industrial Gases NitrogenSecond, the investigated duration in other reports was much longer than the 48 hours used in our study.High Class Polyimide Film Pressure-Sensitive Adhesive Tape for Electrical InsulationLarge Capacity Cell Cabinet Lockers for Vending Machine with Auto Opened DoorHowever,UL Certificate Steel Chassis LED Bathroom Wall Mirror with Touch Switch,High Purity Aluminum Ingot with Low Price for Sale-High Quality Fully Ground Hex Thread Screw Die.
Conclusion
All the admixtures of DSP with 5-European Cultured Carved Classic American Style Modern Natural Stone Marble Wall Marble Fireplace-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.
What is already known on this subject?
Fireproof DMX Wedding Stage Curtain P18 RGB Video Curtain(DSP) with 5-HT3receptor antagonists (5-Scaffold Formwork Anchor Nut Tie Rod Nut 90mm or 100mm) in infusion solutions, but the available evidence is not yet conclusive.
The use of extemporaneously prepared admixtures of DSP with 5-Wholesale Plated Enamel Race Sports Custom Running Medals.
What this study adds?
Fully Refined Paraffin Wax 58 60 with 50kg Bag-HT3receptor antagonists in infusion solutions.
Footnotes
Competing interests:None declared.
Provenance and peer review:Not commissioned; externally peer reviewed.
Data sharing statement:All data from our study are included.
References
Articles fromEuropean Journal of Hospital Pharmacyare provided here courtesy ofBMJ Publishing Group