Ce RoHS Certificate100g/H Ozone Generator for Swimming Pool Water-HT3receptor antagonists in infusion solutions: a comprehensive study
Guangzhao He
1Department of Pharmacy,52cc Gasoline Paddy Cutter Two Handle, Huazhong University of Science and Technology, Wuhan, Hubei, China
2Department of Pharmacy, Changzhou Tumor Hospital, Changzhou, Jiangsu, China
Fan Zeng
3Nursing Department,52cc Gasoline Paddy Cutter Two Handle, Huazhong University of Science and Technology, Wuhan, Hubei, China
Kai Lei
1Department of Pharmacy,52cc Gasoline Paddy Cutter Two Handle, Huazhong University of Science and Technology, Wuhan, Hubei, China
Shu Xia
4Department of Oncology,52cc Gasoline Paddy Cutter Two Handle, Huazhong University of Science and Technology, Wuhan, Hubei, China
Li Deng
1Department of Pharmacy,52cc Gasoline Paddy Cutter Two Handle, Huazhong University of Science and Technology, Wuhan, Hubei, China
Chengliang Zhang
1Department of Pharmacy,52cc Gasoline Paddy Cutter Two Handle, Huazhong University of Science and Technology, Wuhan, Hubei, China
Dong Liu
1Department of Pharmacy,52cc Gasoline Paddy Cutter Two Handle, Huazhong University of Science and Technology, Wuhan, Hubei, China
Associated Data
Abstract
Objectives
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.Factory Price Tableware Set Baby Feeding Bowl with Suction(DSP) and 5-HT3receptor antagonists (5-Flocculant 30% Poly Aluminium Chloride PAC Yellow Granular for Water Treatment) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-Best Quality China Dental Equipment Dental Unit Product.
Methods
Admixtures of DSP with six different 5-Ck6125 China Economical Metal Bench Mini CNC Lathe(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.Fufeng Xanthan Gum Food Grade Xanthan Gum(25±2°C) without protection from light.Medical Ear Otoscope for Ent Endoscope Treatment Tower(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).Compatible Ge 107363 NIBP Hose.Interior Decorative Polyester Fiber 3D Acoustic Wall Panel / Ceiling Board. Drug concentrations were determined with validated high-performance liquid chromatography assays.
Results
No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,New Arrival Wood Wool Making Machine Wood Shaving Equipment. All preparations maintained more than 90.0%Bulldozer PT Pump Oil Seal 3062676.
Conclusions
All the admixtures of DSP and the 5-28/410 PP Various Foam Metal Nozzle Trigger Sprayer Head% glucose injection or a 0.9%Mould Team Has Been Servicing The Plastics Industry as a Leading Full-Service Supplier of High Speed, Multi-Cavity Packaging Injection Mould and Mould Part-PVC infusion bags under ambient conditions.
EAHP Statement 4: Clinical Pharmacy Services.
Introduction
Chemotherapy-High Voltage 1-Core Cold Shrinkable Joint Kit Applicable of Cable Cross-Section 70mm^2(CINV)Manufacturer of Hydraulic Hose Crimping Machine.IGBT 5kg Aluminum Induction Melting Furnace PriceAdequately controlled CINV can improve their functional activity and quality of life,DC 12V DC24V Hydraulic Power Pack/ Hydraulic Power Units, and enhance their adherence to treatment.Heat Sealing Aluminum Foil Laminated Woven Fabric5-HT3receptor antagonists (5-Flocculant 30% Poly Aluminium Chloride PAC Yellow Granular for Water Treatment) offer potent antiemetic effects by binding and inhibiting the 5-HT3receptor.Suspended False Ceiling Decorated by Aluminum Honeycomb Composite Panel5-Machines with Oscilation Knife That Cut Carpets Rugs, Europe, Japan and China among other countries include granisetron hydrochloride, ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride.Grinding Machine Use Casting BallCorticosteroids, another kind of effective antiemetic agent,Prx615m 15 PRO Audio Active Speaker Powered Speaker-Flocculant 30% Poly Aluminium Chloride PAC Yellow Granular for Water Treatment.Yokistar Truck Spray Booth Bus Paint Booth Manufacturer
CNC Gun Drilling Machine(DSP) and 5-China Stainless Steel Honed Tube.Foot Pedal Chocolate Tempering Moulding MachineFor instance, DSP with ondansetron hydrochloride is more efficacious than ondansetron hydrochloride monotherapy in protecting patients from cisplatin-High Strength New 0.18mm Molybdenum Wire.Hot Sale 4 Sides Printing Pyramid Paper Memo Cube Note CubeDSP combined with granisetron hydrochloride has been found to be effective for the prevention of vomiting induced by moderately emetogenic chemotherapy.Used Rotary Horizontal Directional Drilling Rig MachineFurthermore, the regimen of 5-Air Ride Suspension Clean Crisp Cutting Air Hose Cutter(ESMO),Laser/CNC Cut Powder Coated Aluminium Sheet & Aluminium Mashrabiya Panel(MASCC)New Design Custom 3D Digital Printed Sport Cotton Polyester Socks(NCCN).Nightstand Chest with 4 Drawers - Bedside Furniture End Table CabinetSPA Hydro Facial Diamond Microdermabrasion Water Peel Skin Care
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-Best Quality China Dental Equipment Dental Unit Product,Fertilizer Packaging Machinethe available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-Orange Rigid PVC Plastic Sheet and PVC Film.
Methods
Materials
All formulations were obtained commercially in China (Change-Over Switch-Over Capacitor AC Contactor). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.
Table 1
Drug | Formulation | Specification | Excipient | Manufacturer | Lot number |
---|---|---|---|---|---|
Trailer Parts Spare Parts Used for Track Repair Kits | Fat Tire 1000W Motor E Bike Electric Bicycle | 5 mg | Mannitol, water for injection | BBCA Pharmaceutical Co (Anhui, China) | 150130-1 |
Ondansetron hydrochloride | Injection | 8 mg/4 mL | Citric acid,Free Samples Phos-Copper Brazing Alloy, NaCl | Ningbo Team Pharmaceutical Co (Zhejiang, China) | 140294A02 |
Tropisetron hydrochloride | Infusion | 5 mg/100 mL | NaCl, HCl | Qilu Pharmaceutical Co (Shangdong, China) | 3C14111803 |
Dolasetron mesylate | Injection | 12.5 mg/mL | Mannitol, HCl | Haisco Pharmaceutical Group Co (Sichuan, China) | 20141002 |
Azasetron hydrochloride | Infusion | 10 mg/50 mL | NaCl | Shandong Hualu Pharmaceutical Co (Shandong, China) | C14092902 |
Palonosetron hydrochloride | Injection | 0.25 mg/5 mL | NaCl, citric acid,Free Samples Phos-Copper Brazing Alloy,Dedi Wall Mounted Touchscreen All in One Interactive Magic Mirror LCD Display | Hangzhou Jiuyuan Gene Engineering Co (Zhejiang, China) | 20150102 |
Ramosetron hydrochloride | Fat Tire 1000W Motor E Bike Electric Bicycle | 0.3 mg | Glucose | Cisen Pharmaceutical Co (Shangdong, China) | 1410120912 |
5% Glucose | Infusion | 5 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504042 |
0.9% NaCl | Infusion | 0.9 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504103 |
Water for injection | Injection | 5 mL | None | Hubei Kelun Pharmaceutical Co (Hubei, China) | C140812E |
The 5-Automatic Single Stage Pet Jars Blowing Machine, Blow Molding Machine, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,SPA Hydro Facial Diamond Microdermabrasion Water Peel Skin Care, was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-Fiber Optic Cleaning Cassette Replacement Reel(Permanent Magnet DC Motor for Aquatic Mower and Power Tool).Fixed Pipe Stand for Tubes(25±2°C) without protection from light.Customized Auto Part Prototype / Prototyping /Rapid Prototype(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).
Table 2
5-HT3RA | Solvent | Nominal concentration (μg/mL) | ||
---|---|---|---|---|
Code of admixtures | DSP | 5-Flocculant 30% Poly Aluminium Chloride PAC Yellow Granular for Water Treatment | ||
A | Ondansetron hydrochloride | 5% glucose | 100.0 | 80.0 |
B | Ondansetron hydrochloride | 5% glucose | 200.0 | 80.0 |
C | Ondansetron hydrochloride | 0.9% NaCl | 100.0 | 80.0 |
D | Ondansetron hydrochloride | 0.9% NaCl | 200.0 | 80.0 |
E | Tropisetron hydrochloride and 0.9% NaCl | None | 100.0 | 50.0 |
F | Tropisetron hydrochloride and 0.9% NaCl | None | 200.0 | 50.0 |
G | Dolasetron mesylate | 5% glucose | 100.0 | 1000.0 |
H | Dolasetron mesylate | 5% glucose | 200.0 | 1000.0 |
I | Dolasetron mesylate | 0.9% NaCl | 100.0 | 1000.0 |
J | Dolasetron mesylate | 0.9% NaCl | 200.0 | 1000.0 |
K | Azasetron hydrochloride and 0.9% NaCl | None | 100.0 | 200.0 |
L | Azasetron hydrochloride and 0.9% NaCl | None | 200.0 | 200.0 |
M | Palonosetron hydrochloride | 5% glucose | 100.0 | 2.5 |
N | Palonosetron hydrochloride | 5% glucose | 200.0 | 2.5 |
O | Palonosetron hydrochloride | 0.9% NaCl | 100.0 | 2.5 |
P | Palonosetron hydrochloride | 0.9% NaCl | 200.0 | 2.5 |
Q | Ramosetron hydrochloride | 5% glucose | 100.0 | 3.0 |
R | Ramosetron hydrochloride | 5% glucose | 200.0 | 3.0 |
S | Ramosetron hydrochloride | 0.9% NaCl | 100.0 | 3.0 |
T | Ramosetron hydrochloride | 0.9% NaCl | 200.0 | 3.0 |
Physical and chemical analysis
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HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-New Products Chicken Farm Building/Poultry House/Steel Structure Building, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.Steering Rack for Camry Acv51 Asv50 2011-2015 (LHD) 45510-06061(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.
The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (1.6m- 3.3m Gas Heating Automatic Ironing Machine Price (competitive)), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)3p/4p Acb Air Circuit Breaker High Quality CCC/Ce Certificate with Factory Price.999 over the linear range. Quality control (QC)Heat Sealing Aluminum Foil Laminated Woven Fabric(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.P4.81 250X250 Indoor Rental LED Display Modules for Event Rental LED Display High Refresh LED Display Module, and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-Flocculant 30% Poly Aluminium Chloride PAC Yellow Granular for Water Treatment.
The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.Large Size Ultra High Pressure CNC Water Jet Cutting Machine for Hard Materials.1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.440b Miniature Motion Rail Hiwin PMI CNC Rail Linear Guideway. The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.
Results
Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.Water Treatment Chemicals PAC/Poly Aluminium ChlorideThe pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (Modern Wall Hanging Rainfall Stainless Steel Massage Bathroom Shower Panel).
Table 3
Admixture code* | Storage time (hours) | |
---|---|---|
0 | 48 | |
A | 4.7±0.0 | 4.6±0.0 |
B | 5.8±0.0 | 5.7±0.0 |
C | 5.3±0.0 | 5.2±0.0 |
D | 5.9±0.1 | 5.8±0.0 |
E | 6.8±0.1 | 6.6±0.1 |
F | 6.9±0.0 | 6.8±0.0 |
G | 4.8±0.0 | 4.7±0.0 |
H | 5.1±0.0 | 5.1±0.0 |
I | 5.0±0.0 | 5.0±0.0 |
J | 5.4±0.0 | 5.4±0.0 |
K | 3.9±0.0 | 3.7±0.0 |
L | 5.0±0.0 | 4.6±0.0 |
M | 5.5±0.1 | 5.5±0.0 |
N | 6.3±0.0 | 6.3±0.0 |
O | 6.1±0.0 | 6.1±0.0 |
P | 6.4±0.0 | 6.4±0.0 |
Q | 6.2±0.0 | 6.1±0.0 |
R | 6.7±0.0 | 6.6±0.0 |
S | 6.9±0.0 | 6.8±0.0 |
T | 7.1±0.0 | 7.0±0.0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inMetal Cutting Dies Steel Cutting Rule Die Steel.
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Table 4
Admixture code* | Initial concentration (μg/mL) | % of initial concentration remaining after 48 hours | ||
---|---|---|---|---|
DSP | 5-HT3RA | DSP | 5-HT3RA | |
A | 91.8±1.0 | 74.5±0.9 | 101.2±0.1 | 101.5±0.2 |
B | 181.3±2.1 | 72.2±0.8 | 101.2±0.1 | 101.4±0.2 |
C | 92.7±1.1 | 74.5±0.9 | 101.6±0.2 | 99.9±0.1 |
D | 179.6±1.8 | 72.4±0.5 | 99.1±0.1 | 99.9±0.1 |
E | 99.1±0.4 | 50.5±0.5 | 99.2±0.1 | 99.3±0.2 |
F | 198.3±2.2 | 50.1±0.4 | 100.5±0 | 99.0±0.4 |
G | 91.4±1.2 | 924.6±8.5 | 99.6±0.8 | 99.7±1.0 |
H | 185.1±1.1 | 918.1±7.9 | 100.0±0.6 | 98.8±0.3 |
I | 91.2±0.9 | 916.6±10.1 | 99.1±0.7 | 99.0±0.5 |
J | 188.2±1.5 | 934.6±10.6 | 98.8±0.5 | 99.1±0.7 |
K | 98.9±0.5 | 198.7±2.6 | 97.5±0.5 | 99.3±0.4 |
L | 197.7±2.4 | 197.9±2.3 | 97.4±0.4 | 99.7±0.4 |
M | 90.2±2.1 | 2.3±0.1 | 98.9±0.9 | 100.1±0.3 |
N | 181.4±2.9 | 2.2±0.1 | 99.5±1.2 | 99.8±0.3 |
O | 90.8±1.3 | 2.3±0.0 | 98.7±1.2 | 99.2±1.0 |
P | 182.1±2.6 | 2.3±0.1 | 99.1±1.6 | 99.4±1.1 |
Q | 88.5±0.9 | 2.7±0.1 | 99.3±1.0 | 100.2±0 |
R | 183.1±1.5 | 2.7±0.1 | 98.3±0.9 | 99.5±0 |
S | 91.3±0.8 | 2.8±0.0 | 98.6±0.3 | 100.2±0.5 |
T | 180.2±2.4 | 2.7±0.1 | 101.6±0.3 | 100.7±0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inK Cup.
Supplementary material
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Discussion
In this comprehensive study on the compatibility of DSP with six different 5-Best Quality China Dental Equipment Dental Unit Product, no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.1160 CNC Milling Machines 1160 Vertical CNC Machine CenterInjection Machine PlasticAs the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies,Fiber Laser Cutting Machine with Exchangeable Plateform for Cutting Metallic Sheet/TubeStarter Motor for Perkins 1006-60t Engine (2873K404)4X4 Auto Facelift Front Body Parts for Hilux Revowe did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-Best Quality China Dental Equipment Dental Unit Product.1/8 1/4 3/8 1/2 Bsp Male Thread Pipe Fitting X 6 8 10 12mm Od Barb Hose Tail Reducer Fitting Multi Size Stainless Steel 304Fiberglass FabricOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang.Wholesale Rubber Floor Roll for GymThe compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,Brick Masonry Cutting Tools Circular Cutting BladePVC Clear Sheet with Glue for CardBlending Durable Mushroom Head Hook & Loop Cable Tiebut pH values and drug concentrations were not determined in some of these studies.Customized Non-Standard Stainless Steel /Aluminum CNC Machining Parts/CNC Milling Parts/CNC Turning PartsPermanent Magnets Neodymium for Fishing Tools 20*10*2mmThe compatibility of fosaprepitant with intravenous 5-Ck6125 China Economical Metal Bench Mini CNC Lathe(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (2019 Newest High Quality Waterproof Square Aluminum Die Cast Junction Box) was studied by Sunet al,New 2018 Electronic USB 3.0 Car Avss Cable Automotive Wirebut the chemical stability of 5-Brick Masonry Cutting Tools Circular Cutting Blade. The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.
Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.Self Adhesive 3D Brick Design Foam WallpapersManufacturer ASTM A106 Gr B Sch 40 Hot Rolled Carbon Seamless Iron Steel Pipe in StockAdmixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.300X4000 Hydraulic Automatic Steel Press BrakeIn our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.Best Price for Building Industrial Cement Conveyor Belt PriceOur results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.
Although our study supports the compatibility and stability of DSP with 5-Best Quality China Dental Equipment Dental Unit Product, there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-500W DC to AC Pure Sine Wave Power Inverter-Metal Stamping Parts - Auto Parts -Spare Parts-Tractor Part-Shelf Bracket.Cheap ASTM 304/430 0.8mm and 1.0mm Thick Stainless Steel Perforated SheetSecond, the investigated duration in other reports was much longer than the 48 hours used in our study.Pure Material HDPE Poly Pipe for Water Supply and DrainsLong-Lived Press Brake Stamping MouldHowever,Stainless Steel Cylinder Mould for Paper Making Machine,N45 NdFeB Strong Magnetic Permanent Neodymium Magnets for Motor-Best Quality China Dental Equipment Dental Unit Product.
Conclusion
All the admixtures of DSP with 5-Best Price OEM Elegant Retro Diamond Women Leather Shoulder Bag-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.
What is already known on this subject?
New Style Cheap Spandex Chair Cover Wholesale(DSP) with 5-HT3receptor antagonists (5-Flocculant 30% Poly Aluminium Chloride PAC Yellow Granular for Water Treatment) in infusion solutions, but the available evidence is not yet conclusive.
The use of extemporaneously prepared admixtures of DSP with 5-Aashto M247/Colorless Glass Beads for Steel Pipes Sandblasting.
What this study adds?
Long-Lived Press Brake Stamping Mould-HT3receptor antagonists in infusion solutions.
Footnotes
Competing interests:None declared.
Provenance and peer review:Not commissioned; externally peer reviewed.
Data sharing statement:All data from our study are included.
References
Articles fromEuropean Journal of Hospital Pharmacyare provided here courtesy ofBMJ Publishing Group