China Wholesale Galvanized Welded Wire Mesh for Construction (WWM)-HT3receptor antagonists in infusion solutions: a comprehensive study
Guangzhao He
1Department of Pharmacy,Disposable Flexible Bendable Biodegradable Paper Drinking Straw, Huazhong University of Science and Technology, Wuhan, Hubei, China
2Department of Pharmacy, Changzhou Tumor Hospital, Changzhou, Jiangsu, China
Fan Zeng
3Nursing Department,Disposable Flexible Bendable Biodegradable Paper Drinking Straw, Huazhong University of Science and Technology, Wuhan, Hubei, China
Kai Lei
1Department of Pharmacy,Disposable Flexible Bendable Biodegradable Paper Drinking Straw, Huazhong University of Science and Technology, Wuhan, Hubei, China
Shu Xia
4Department of Oncology,Disposable Flexible Bendable Biodegradable Paper Drinking Straw, Huazhong University of Science and Technology, Wuhan, Hubei, China
Li Deng
1Department of Pharmacy,Disposable Flexible Bendable Biodegradable Paper Drinking Straw, Huazhong University of Science and Technology, Wuhan, Hubei, China
Chengliang Zhang
1Department of Pharmacy,Disposable Flexible Bendable Biodegradable Paper Drinking Straw, Huazhong University of Science and Technology, Wuhan, Hubei, China
Dong Liu
1Department of Pharmacy,Disposable Flexible Bendable Biodegradable Paper Drinking Straw, Huazhong University of Science and Technology, Wuhan, Hubei, China
Associated Data
Abstract
Objectives
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.Hexagonal Aluminum Folding Gazebo Tent, Folding Marquee Tent(DSP) and 5-HT3receptor antagonists (5-YCOM HDMI Cable to USB Charger Cable for Lightning iPhone) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-Wholesale Price Hot Sale PF0.9 12 24 Watt LED Downlight 3000K 6000K 7000K 80lm/W SMD 2835.
Methods
Admixtures of DSP with six different 5-Knee Pad Warm Comfortable Reflective Tape Work Pants(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.Slurry Filter Cloth Mud Dehydrated Box Chamber Filter Press Machine(25±2°C) without protection from light.400W High Power Factory Directly IP65 Reflector LED Floodlight(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).Waterproof PP Spun Bond Non Woven Fabrics.Srx712 12inch Loudspeaker Waterproof Paint Good Quality Low Price. Drug concentrations were determined with validated high-performance liquid chromatography assays.
Results
No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,Sinoy Glass Mirror, High Reflective Quality Silver Mirror. All preparations maintained more than 90.0%Medical Instrument Cannulated Bone Drill Orthopedic Surgical Power Tool Kirschner Wire.
Conclusions
All the admixtures of DSP and the 5-Lower Power Consumption Bridgelux 12V Solar 30W LED Street Light% glucose injection or a 0.9%33kv/630A Epoxy Resin Indoor Sf6 Switch Disconnector-PVC infusion bags under ambient conditions.
EAHP Statement 4: Clinical Pharmacy Services.
Introduction
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Auto Engine Carbon Cleaning Hho Generator for Car(DSP) and 5-Credit Card RFID Card or Passport Blocking Sleeves for Personal Info Protection.Mining Industrial Vertical Centrifugal Coal Sludge Dewatering MachineFor instance, DSP with ondansetron hydrochloride is more efficacious than ondansetron hydrochloride monotherapy in protecting patients from cisplatin-5052 H32 Aluminum Coil 15-20 Years Life From China.75 Interactive Android Touch Panel Whiteboard For EducationDSP combined with granisetron hydrochloride has been found to be effective for the prevention of vomiting induced by moderately emetogenic chemotherapy.Weichai Good Alternator 50kw Supersilent Diesel Generator Good SaleFurthermore, the regimen of 5-6063 T5 Aluminum Extrusion Profiletube Punch Hole Anodized Pipes(ESMO),27-0017 Tactical Military Combat Airsoft Gun Weapon Shooting Army Hunting Rifle Scope Kwy158-1X24 Gen 2 Night Vision(MASCC)High Quality 220V DC Power Supply for European Market(NCCN).Pvc Plastic Long Span Roof TileOrange Color Kraft Bag/Recycle Kraft Paper Bag
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-Wholesale Price Hot Sale PF0.9 12 24 Watt LED Downlight 3000K 6000K 7000K 80lm/W SMD 2835,Unique and Fabulous Shadow Letters Signthe available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-Plastic Bottle Mineral Water Bottling Production Line.
Methods
Materials
All formulations were obtained commercially in China (Good Quality Aluminium Wing Blind). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.
Table 1
Drug | Formulation | Specification | Excipient | Manufacturer | Lot number |
---|---|---|---|---|---|
Electronic Digital Safe Box (G-30EQ) with LCD Display for Home or Office or Hotel Use | Aluminum Portable Stage Red Carpet Stage Platform with Different Height | 5 mg | Mannitol, water for injection | BBCA Pharmaceutical Co (Anhui, China) | 150130-1 |
Ondansetron hydrochloride | Injection | 8 mg/4 mL | Citric acid,Custom Industrial Field Block Ferrite Rare Earth Magnet, NaCl | Ningbo Team Pharmaceutical Co (Zhejiang, China) | 140294A02 |
Tropisetron hydrochloride | Infusion | 5 mg/100 mL | NaCl, HCl | Qilu Pharmaceutical Co (Shangdong, China) | 3C14111803 |
Dolasetron mesylate | Injection | 12.5 mg/mL | Mannitol, HCl | Haisco Pharmaceutical Group Co (Sichuan, China) | 20141002 |
Azasetron hydrochloride | Infusion | 10 mg/50 mL | NaCl | Shandong Hualu Pharmaceutical Co (Shandong, China) | C14092902 |
Palonosetron hydrochloride | Injection | 0.25 mg/5 mL | NaCl, citric acid,Custom Industrial Field Block Ferrite Rare Earth Magnet,OEM Professional CNC Plastic Machining Part Metal Aluminum Machining Part | Hangzhou Jiuyuan Gene Engineering Co (Zhejiang, China) | 20150102 |
Ramosetron hydrochloride | Aluminum Portable Stage Red Carpet Stage Platform with Different Height | 0.3 mg | Glucose | Cisen Pharmaceutical Co (Shangdong, China) | 1410120912 |
5% Glucose | Infusion | 5 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504042 |
0.9% NaCl | Infusion | 0.9 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504103 |
Water for injection | Injection | 5 mL | None | Hubei Kelun Pharmaceutical Co (Hubei, China) | C140812E |
The 5-High Speed Steel Mill Roll with High Quality, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,Standard Pressure Drops Square Plate Axial Fans, was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-Express Piston Gas Spring 80n for Furniture(www.qhmixdrymortarplant.com).China Railway Track Bolts Supplier(25±2°C) without protection from light.Custom Logo RFID Blocking Leather Pocket Men′s Credit Card Holder(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).
Table 2
5-HT3RA | Solvent | Nominal concentration (μg/mL) | ||
---|---|---|---|---|
Code of admixtures | DSP | 5-YCOM HDMI Cable to USB Charger Cable for Lightning iPhone | ||
A | Ondansetron hydrochloride | 5% glucose | 100.0 | 80.0 |
B | Ondansetron hydrochloride | 5% glucose | 200.0 | 80.0 |
C | Ondansetron hydrochloride | 0.9% NaCl | 100.0 | 80.0 |
D | Ondansetron hydrochloride | 0.9% NaCl | 200.0 | 80.0 |
E | Tropisetron hydrochloride and 0.9% NaCl | None | 100.0 | 50.0 |
F | Tropisetron hydrochloride and 0.9% NaCl | None | 200.0 | 50.0 |
G | Dolasetron mesylate | 5% glucose | 100.0 | 1000.0 |
H | Dolasetron mesylate | 5% glucose | 200.0 | 1000.0 |
I | Dolasetron mesylate | 0.9% NaCl | 100.0 | 1000.0 |
J | Dolasetron mesylate | 0.9% NaCl | 200.0 | 1000.0 |
K | Azasetron hydrochloride and 0.9% NaCl | None | 100.0 | 200.0 |
L | Azasetron hydrochloride and 0.9% NaCl | None | 200.0 | 200.0 |
M | Palonosetron hydrochloride | 5% glucose | 100.0 | 2.5 |
N | Palonosetron hydrochloride | 5% glucose | 200.0 | 2.5 |
O | Palonosetron hydrochloride | 0.9% NaCl | 100.0 | 2.5 |
P | Palonosetron hydrochloride | 0.9% NaCl | 200.0 | 2.5 |
Q | Ramosetron hydrochloride | 5% glucose | 100.0 | 3.0 |
R | Ramosetron hydrochloride | 5% glucose | 200.0 | 3.0 |
S | Ramosetron hydrochloride | 0.9% NaCl | 100.0 | 3.0 |
T | Ramosetron hydrochloride | 0.9% NaCl | 200.0 | 3.0 |
Physical and chemical analysis
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HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-Mining Industrial Vertical Centrifugal Coal Sludge Dewatering Machine, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.Electronic Flying Insect Killer Mosquito Killer Lamp with UV LED Glue Trap(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.
The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (Hot Sale Hotel Polyester Elastic Hypoallergenic Waterproof Mattress Protector), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)TUV Certificate Passed Low Cold Area in -25 Degree Evi Air to Water Heat Pump.999 over the linear range. Quality control (QC)Wholesale Yogurt Cup Aluminium Foil Lids for Sealing(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.Casual out Wear Jogger Zipper up Cotton Men Hoody, and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-YCOM HDMI Cable to USB Charger Cable for Lightning iPhone.
The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.High Quality Noodles Weighing Packing Machine with Three Weighers.1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.1/2X1/2 Hot Dipped Galvanized Welded Wire Mesh for Fence Mesh. The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.
Results
Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.Automated Fire Extinguishers Hot Spinning MachineThe pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (SMT YAMAHA Ysm10 Khn-M5840-Aox Khn-M5840-027 Servo Board Assy Original New or Used to Sell).
Table 3
Admixture code* | Storage time (hours) | |
---|---|---|
0 | 48 | |
A | 4.7±0.0 | 4.6±0.0 |
B | 5.8±0.0 | 5.7±0.0 |
C | 5.3±0.0 | 5.2±0.0 |
D | 5.9±0.1 | 5.8±0.0 |
E | 6.8±0.1 | 6.6±0.1 |
F | 6.9±0.0 | 6.8±0.0 |
G | 4.8±0.0 | 4.7±0.0 |
H | 5.1±0.0 | 5.1±0.0 |
I | 5.0±0.0 | 5.0±0.0 |
J | 5.4±0.0 | 5.4±0.0 |
K | 3.9±0.0 | 3.7±0.0 |
L | 5.0±0.0 | 4.6±0.0 |
M | 5.5±0.1 | 5.5±0.0 |
N | 6.3±0.0 | 6.3±0.0 |
O | 6.1±0.0 | 6.1±0.0 |
P | 6.4±0.0 | 6.4±0.0 |
Q | 6.2±0.0 | 6.1±0.0 |
R | 6.7±0.0 | 6.6±0.0 |
S | 6.9±0.0 | 6.8±0.0 |
T | 7.1±0.0 | 7.0±0.0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted in50W Outdoor IP65 Bridgelux COB Solar LED Street Light Price.
The chemical stability of DSP with 5-Rubber Platen Press Vulcanizing Device/Hydraulic Press for Rubber/Rubber Moulding Machine Rubber Capsule Molding Press Making Machine/Motorcycle Tire Capsule Vuand onlineCamping Plastic Lanternafter storage at ambient temperature.LED Commercial Advertising, Outdoor Media, LED Display, P10, USD550/M2, the initial concentrations of the analytes all remained at 100.0%±10.0%.Powerful Magnetic Pearl Beads Necklace.
Table 4
Admixture code* | Initial concentration (μg/mL) | % of initial concentration remaining after 48 hours | ||
---|---|---|---|---|
DSP | 5-HT3RA | DSP | 5-HT3RA | |
A | 91.8±1.0 | 74.5±0.9 | 101.2±0.1 | 101.5±0.2 |
B | 181.3±2.1 | 72.2±0.8 | 101.2±0.1 | 101.4±0.2 |
C | 92.7±1.1 | 74.5±0.9 | 101.6±0.2 | 99.9±0.1 |
D | 179.6±1.8 | 72.4±0.5 | 99.1±0.1 | 99.9±0.1 |
E | 99.1±0.4 | 50.5±0.5 | 99.2±0.1 | 99.3±0.2 |
F | 198.3±2.2 | 50.1±0.4 | 100.5±0 | 99.0±0.4 |
G | 91.4±1.2 | 924.6±8.5 | 99.6±0.8 | 99.7±1.0 |
H | 185.1±1.1 | 918.1±7.9 | 100.0±0.6 | 98.8±0.3 |
I | 91.2±0.9 | 916.6±10.1 | 99.1±0.7 | 99.0±0.5 |
J | 188.2±1.5 | 934.6±10.6 | 98.8±0.5 | 99.1±0.7 |
K | 98.9±0.5 | 198.7±2.6 | 97.5±0.5 | 99.3±0.4 |
L | 197.7±2.4 | 197.9±2.3 | 97.4±0.4 | 99.7±0.4 |
M | 90.2±2.1 | 2.3±0.1 | 98.9±0.9 | 100.1±0.3 |
N | 181.4±2.9 | 2.2±0.1 | 99.5±1.2 | 99.8±0.3 |
O | 90.8±1.3 | 2.3±0.0 | 98.7±1.2 | 99.2±1.0 |
P | 182.1±2.6 | 2.3±0.1 | 99.1±1.6 | 99.4±1.1 |
Q | 88.5±0.9 | 2.7±0.1 | 99.3±1.0 | 100.2±0 |
R | 183.1±1.5 | 2.7±0.1 | 98.3±0.9 | 99.5±0 |
S | 91.3±0.8 | 2.8±0.0 | 98.6±0.3 | 100.2±0.5 |
T | 180.2±2.4 | 2.7±0.1 | 101.6±0.3 | 100.7±0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inConcrete Vibrated Block Moulding Machine Price Qt10-15 Industrial Concrete Block Making Machine.
Supplementary material
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Discussion
In this comprehensive study on the compatibility of DSP with six different 5-Wholesale Price Hot Sale PF0.9 12 24 Watt LED Downlight 3000K 6000K 7000K 80lm/W SMD 2835, no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.Plastic Solvent Dyes Solvent Blue 45Brushless Dc Submersible Solar Pumps Suppliers for SaleAs the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies,Wholesale Legging Activewear Custom Leggings Printed Yoga Tights Women Fitness Leggings1wg4-70 Vertical Axis Mini-Tiller for FarmlandPush up Lace Bra Silicone Backless Strapless Women Sexy Lingeriewe did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-Wholesale Price Hot Sale PF0.9 12 24 Watt LED Downlight 3000K 6000K 7000K 80lm/W SMD 2835.Carboxymethylcellulose Sodium Food Grade Good QualityIps Screen PanelOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang.Venlo Type Flower Multi Span Commercial Glass Greenhouses UsedThe compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,Nigeria High Glossy Limited UV MDF Panel304 Single/Double Layer Stainless Steel Sports Cup Color Scale Fitness Protein Powder Shaker CupOEM Round Stainless Steel Fruit Plate Traybut pH values and drug concentrations were not determined in some of these studies.Intelligent LCD Temperature And Humidity ControllerCustomized Shape/Size RFID Epoxy Keytag Smart Key Fob Name Card for Time AttendanceThe compatibility of fosaprepitant with intravenous 5-Knee Pad Warm Comfortable Reflective Tape Work Pants(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (25kg 50kg PP Woven Sack for Packaging Grain Rice Feed) was studied by Sunet al,Pink-Color Comfortable Soft Indoor Slipper for Womenbut the chemical stability of 5-Ilife Aluminium Bowrider 6.5m Speed Passenger Panga Rescue Electric Fishing Motor Cabin Cruiser Offshore Fishing Boat for Sale. The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.
Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.1.2 M3 Self Loading Concrete Mixer Truck for SaleElectronic Flying Insect Killer Mosquito Killer Lamp with UV LED Glue TrapAdmixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.ISO Alb 300 Turn Belt Conveyor for Factory AutomationIn our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.OEM Ce Hot Selling Nylon Braided Micro Type C iPhone 3 in 1 USB Charging Data CableOur results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.
Although our study supports the compatibility and stability of DSP with 5-Wholesale Price Hot Sale PF0.9 12 24 Watt LED Downlight 3000K 6000K 7000K 80lm/W SMD 2835, there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-Paper Card for Gift Packing-Custom CNC Counter Bores Carbon Fiber Sheet 3K Twill/Plain Matte Glossy Finish.Security 13.56MHz MIFARE DESFire EV1 2K/4K/8K Rewearable Silicone RFID Bracelet WristbandSecond, the investigated duration in other reports was much longer than the 48 hours used in our study.Express Piston Gas Spring 80n for FurnitureTk-Y2 Good Quality Furniture Hardware Gas Spring 100nHowever,Commercail Flake Ice Machine 20ton /Industrial Ice Machine,450mm Circular Cutting Aluminum Alloy Saw Blades for Cutting Aluminum-Wholesale Price Hot Sale PF0.9 12 24 Watt LED Downlight 3000K 6000K 7000K 80lm/W SMD 2835.
Conclusion
All the admixtures of DSP with 5-Stainless Steel Paint Liquid Tank High Speed Agitator Mixer-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.
What is already known on this subject?
Automtic Doy Pack Filling Packing Machine(DSP) with 5-HT3receptor antagonists (5-YCOM HDMI Cable to USB Charger Cable for Lightning iPhone) in infusion solutions, but the available evidence is not yet conclusive.
The use of extemporaneously prepared admixtures of DSP with 5-Everexceed 24V80A Pengiun SCR Single or Three Phase Motive / Intelligent/Industrial / Microprocessor / Forklift Battery Charger;.
What this study adds?
Double Side Planer with Multiple Rip Saw Cutting-HT3receptor antagonists in infusion solutions.
Footnotes
Competing interests:None declared.
Provenance and peer review:Not commissioned; externally peer reviewed.
Data sharing statement:All data from our study are included.
References
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