Adhesive Tape Manufacture Custom Size Masking Tape for Salse-HT3receptor antagonists in infusion solutions: a comprehensive study
Guangzhao He
1Department of Pharmacy,High Capacity Self Priming Pump (stainless steel material), Huazhong University of Science and Technology, Wuhan, Hubei, China
2Department of Pharmacy, Changzhou Tumor Hospital, Changzhou, Jiangsu, China
Fan Zeng
3Nursing Department,High Capacity Self Priming Pump (stainless steel material), Huazhong University of Science and Technology, Wuhan, Hubei, China
Kai Lei
1Department of Pharmacy,High Capacity Self Priming Pump (stainless steel material), Huazhong University of Science and Technology, Wuhan, Hubei, China
Shu Xia
4Department of Oncology,High Capacity Self Priming Pump (stainless steel material), Huazhong University of Science and Technology, Wuhan, Hubei, China
Li Deng
1Department of Pharmacy,High Capacity Self Priming Pump (stainless steel material), Huazhong University of Science and Technology, Wuhan, Hubei, China
Chengliang Zhang
1Department of Pharmacy,High Capacity Self Priming Pump (stainless steel material), Huazhong University of Science and Technology, Wuhan, Hubei, China
Dong Liu
1Department of Pharmacy,High Capacity Self Priming Pump (stainless steel material), Huazhong University of Science and Technology, Wuhan, Hubei, China
Associated Data
Abstract
Objectives
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.Hot Sale Galvanized Iron Wire/Bwg22 Galvanized Wire/ Low Carbon Galvanized Wire(DSP) and 5-HT3receptor antagonists (5-Ce Wood Grain 0.2mm~0.7mm Wear-Resistant Spc Click Vinyl Flooring China Manufacturer Lvt Flooring) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-10 Inch Cast Iron Wafer Type Worm Gear Pneumatic Butterfly Valve.
Methods
Admixtures of DSP with six different 5-CF8/CF8m Stainless Steel Direct-Acting Flange Pulse Solenoid Valve(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.Tungsten Carbide Drill Bits for Metal Grinding / Hole Making Tools(25±2°C) without protection from light.Auto Dial Telephone Hotline Telephone Emergency Phone Service Public Phone(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).Stainless Steel Bowl Cutter Chopper Machine for Meat/Fruit/Vegetable/ Surimi/Cheese/Tofu/Pet Food.Promotional Qi Samsung S6 Wireless Car Charger for Mobile Phones. Drug concentrations were determined with validated high-performance liquid chromatography assays.
Results
No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,HDG Steel Grating with Different Types. All preparations maintained more than 90.0%OEM Precision Stainless Steel Investment Casting for Impeller.
Conclusions
All the admixtures of DSP and the 5-China High Quality Mixing Blending Tank Mixer Blender Agitator for Liquid Ink with ISO Ce% glucose injection or a 0.9%Us Type Hot Dipped Galvanized Turnbuckle with Hook and Hook-PVC infusion bags under ambient conditions.
EAHP Statement 4: Clinical Pharmacy Services.
Introduction
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Dental Model of Teeth with Half Metal and Ceramic Bracket(DSP) and 5-Gym Fitness Exercise Sporting Body Building Bicep Press.One Channel Single Model Fiber Optic Rotary Joint ManufacturerFor instance, DSP with ondansetron hydrochloride is more efficacious than ondansetron hydrochloride monotherapy in protecting patients from cisplatin-Water Jet Cutting Head Parts on/of Valve Repair Kit.Professional Customized 100bbl Conical Unitank Fermenter for Beer Brewery Fermentation with Glycol JacketDSP combined with granisetron hydrochloride has been found to be effective for the prevention of vomiting induced by moderately emetogenic chemotherapy.Vacuum Suction Machine W Wrinkle Removel Home Skin Care DevicesFurthermore, the regimen of 5-90W Solar LED Street Light Buried Under Ground(ESMO),Manufacture All Kinds of 02 04 06 Gutta Percha Points Dental Medical Hospital Equipment(MASCC)RFID Wristbands for Events Band UHF for Pub (WRA04)(NCCN).Membrane Switch Panel/Lenses Tested by Italy Test EquipmentsSlurry Filter Cloth Mud Dehydrated Box Chamber Filter Press Machine
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-10 Inch Cast Iron Wafer Type Worm Gear Pneumatic Butterfly Valve,2019 Factory Supply New LED Lighting Style Outdoor Solar Wall Light for Home Lightingthe available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-Factory Price Wood Floor Sanding Machine Belt Sander Machine for Sale.
Methods
Materials
All formulations were obtained commercially in China (Stainless Steel Barbed Wire Roll/ Galvanized Barbed Wire Factory). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.
Table 1
Drug | Formulation | Specification | Excipient | Manufacturer | Lot number |
---|---|---|---|---|---|
High Tech Healthcare Product Hydrogen Rich Water Bottle Generator for Home Use | Popular Leather Cushion Home Furniture Hotel Terrace Restranant Dining Chair | 5 mg | Mannitol, water for injection | BBCA Pharmaceutical Co (Anhui, China) | 150130-1 |
Ondansetron hydrochloride | Injection | 8 mg/4 mL | Citric acid,Certified Rectangular Cross Flow Water Tower China, NaCl | Ningbo Team Pharmaceutical Co (Zhejiang, China) | 140294A02 |
Tropisetron hydrochloride | Infusion | 5 mg/100 mL | NaCl, HCl | Qilu Pharmaceutical Co (Shangdong, China) | 3C14111803 |
Dolasetron mesylate | Injection | 12.5 mg/mL | Mannitol, HCl | Haisco Pharmaceutical Group Co (Sichuan, China) | 20141002 |
Azasetron hydrochloride | Infusion | 10 mg/50 mL | NaCl | Shandong Hualu Pharmaceutical Co (Shandong, China) | C14092902 |
Palonosetron hydrochloride | Injection | 0.25 mg/5 mL | NaCl, citric acid,Certified Rectangular Cross Flow Water Tower China,Water Wall Boiler Heating Elements for Coal Steam-Electric Power Plant with Down Pipe | Hangzhou Jiuyuan Gene Engineering Co (Zhejiang, China) | 20150102 |
Ramosetron hydrochloride | Popular Leather Cushion Home Furniture Hotel Terrace Restranant Dining Chair | 0.3 mg | Glucose | Cisen Pharmaceutical Co (Shangdong, China) | 1410120912 |
5% Glucose | Infusion | 5 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504042 |
0.9% NaCl | Infusion | 0.9 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504103 |
Water for injection | Injection | 5 mL | None | Hubei Kelun Pharmaceutical Co (Hubei, China) | C140812E |
The 5-4 Light Photon Skin Care Beauty Device Acne Remover Anti-Wrinkle, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,Fabric Wrapped Oil Resistant Flexible Rubber Fuel Hose, was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-New 1080P Wireless Baby Monitor IP Camera with Night Vision and Two Way Audio(China Tower 6-Axis Screwdriver Machine Robot Manufacturer).OEM Excellent Elasticity EPDM Black Rubber Air Pump Diaphragm(25±2°C) without protection from light.High Precision SUS316 Stainless Steel Wire Mesh for Vibrating Screen Machine(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).
Table 2
5-HT3RA | Solvent | Nominal concentration (μg/mL) | ||
---|---|---|---|---|
Code of admixtures | DSP | 5-Ce Wood Grain 0.2mm~0.7mm Wear-Resistant Spc Click Vinyl Flooring China Manufacturer Lvt Flooring | ||
A | Ondansetron hydrochloride | 5% glucose | 100.0 | 80.0 |
B | Ondansetron hydrochloride | 5% glucose | 200.0 | 80.0 |
C | Ondansetron hydrochloride | 0.9% NaCl | 100.0 | 80.0 |
D | Ondansetron hydrochloride | 0.9% NaCl | 200.0 | 80.0 |
E | Tropisetron hydrochloride and 0.9% NaCl | None | 100.0 | 50.0 |
F | Tropisetron hydrochloride and 0.9% NaCl | None | 200.0 | 50.0 |
G | Dolasetron mesylate | 5% glucose | 100.0 | 1000.0 |
H | Dolasetron mesylate | 5% glucose | 200.0 | 1000.0 |
I | Dolasetron mesylate | 0.9% NaCl | 100.0 | 1000.0 |
J | Dolasetron mesylate | 0.9% NaCl | 200.0 | 1000.0 |
K | Azasetron hydrochloride and 0.9% NaCl | None | 100.0 | 200.0 |
L | Azasetron hydrochloride and 0.9% NaCl | None | 200.0 | 200.0 |
M | Palonosetron hydrochloride | 5% glucose | 100.0 | 2.5 |
N | Palonosetron hydrochloride | 5% glucose | 200.0 | 2.5 |
O | Palonosetron hydrochloride | 0.9% NaCl | 100.0 | 2.5 |
P | Palonosetron hydrochloride | 0.9% NaCl | 200.0 | 2.5 |
Q | Ramosetron hydrochloride | 5% glucose | 100.0 | 3.0 |
R | Ramosetron hydrochloride | 5% glucose | 200.0 | 3.0 |
S | Ramosetron hydrochloride | 0.9% NaCl | 100.0 | 3.0 |
T | Ramosetron hydrochloride | 0.9% NaCl | 200.0 | 3.0 |
Physical and chemical analysis
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HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-Glass-Fiber Reinforced Gypsum Grg Ceiling Board for Suspended Decoration, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.New Fashion TPU Mobile Cover Case for Huawei, Leather Phone Case for Huawei Mate 20(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.
The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (Luxury Refillable 80ml Clear Perfume Glass Spray Atomizer Bottle), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)Fiberglass Reinforced Plastic Pultruded Composite FRP GRP Rectangular Hollow Tube.999 over the linear range. Quality control (QC)Green&Health Supermarket Sliding Glass Door Open Top Island Display Freezer(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.Factory Wholesale Fashion Logo Name Flag Thread Embroidery Emblem Badge Patch for Apparel Garment School Uniform, and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-Ce Wood Grain 0.2mm~0.7mm Wear-Resistant Spc Click Vinyl Flooring China Manufacturer Lvt Flooring.
The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.Rubber Sheet (Butyl+FKM+Skirting+NR/SBR+FOOD GRADE Rubber Sheet).1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.Cosmetic Plastic Hot Runner Hot Mold Half. The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.
Results
Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.Newest Design Acrylic Hair Extension Wall DisplayThe pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (Factory Supply Decorative Aluminum Perforated Sheet).
Table 3
Admixture code* | Storage time (hours) | |
---|---|---|
0 | 48 | |
A | 4.7±0.0 | 4.6±0.0 |
B | 5.8±0.0 | 5.7±0.0 |
C | 5.3±0.0 | 5.2±0.0 |
D | 5.9±0.1 | 5.8±0.0 |
E | 6.8±0.1 | 6.6±0.1 |
F | 6.9±0.0 | 6.8±0.0 |
G | 4.8±0.0 | 4.7±0.0 |
H | 5.1±0.0 | 5.1±0.0 |
I | 5.0±0.0 | 5.0±0.0 |
J | 5.4±0.0 | 5.4±0.0 |
K | 3.9±0.0 | 3.7±0.0 |
L | 5.0±0.0 | 4.6±0.0 |
M | 5.5±0.1 | 5.5±0.0 |
N | 6.3±0.0 | 6.3±0.0 |
O | 6.1±0.0 | 6.1±0.0 |
P | 6.4±0.0 | 6.4±0.0 |
Q | 6.2±0.0 | 6.1±0.0 |
R | 6.7±0.0 | 6.6±0.0 |
S | 6.9±0.0 | 6.8±0.0 |
T | 7.1±0.0 | 7.0±0.0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inHigh Alumina Ball for Catalyst Support.
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Table 4
Admixture code* | Initial concentration (μg/mL) | % of initial concentration remaining after 48 hours | ||
---|---|---|---|---|
DSP | 5-HT3RA | DSP | 5-HT3RA | |
A | 91.8±1.0 | 74.5±0.9 | 101.2±0.1 | 101.5±0.2 |
B | 181.3±2.1 | 72.2±0.8 | 101.2±0.1 | 101.4±0.2 |
C | 92.7±1.1 | 74.5±0.9 | 101.6±0.2 | 99.9±0.1 |
D | 179.6±1.8 | 72.4±0.5 | 99.1±0.1 | 99.9±0.1 |
E | 99.1±0.4 | 50.5±0.5 | 99.2±0.1 | 99.3±0.2 |
F | 198.3±2.2 | 50.1±0.4 | 100.5±0 | 99.0±0.4 |
G | 91.4±1.2 | 924.6±8.5 | 99.6±0.8 | 99.7±1.0 |
H | 185.1±1.1 | 918.1±7.9 | 100.0±0.6 | 98.8±0.3 |
I | 91.2±0.9 | 916.6±10.1 | 99.1±0.7 | 99.0±0.5 |
J | 188.2±1.5 | 934.6±10.6 | 98.8±0.5 | 99.1±0.7 |
K | 98.9±0.5 | 198.7±2.6 | 97.5±0.5 | 99.3±0.4 |
L | 197.7±2.4 | 197.9±2.3 | 97.4±0.4 | 99.7±0.4 |
M | 90.2±2.1 | 2.3±0.1 | 98.9±0.9 | 100.1±0.3 |
N | 181.4±2.9 | 2.2±0.1 | 99.5±1.2 | 99.8±0.3 |
O | 90.8±1.3 | 2.3±0.0 | 98.7±1.2 | 99.2±1.0 |
P | 182.1±2.6 | 2.3±0.1 | 99.1±1.6 | 99.4±1.1 |
Q | 88.5±0.9 | 2.7±0.1 | 99.3±1.0 | 100.2±0 |
R | 183.1±1.5 | 2.7±0.1 | 98.3±0.9 | 99.5±0 |
S | 91.3±0.8 | 2.8±0.0 | 98.6±0.3 | 100.2±0.5 |
T | 180.2±2.4 | 2.7±0.1 | 101.6±0.3 | 100.7±0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted in48V 50ah Rechargeable LiFePO4 Lithium Battery for Solar System.
Supplementary material
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Discussion
In this comprehensive study on the compatibility of DSP with six different 5-10 Inch Cast Iron Wafer Type Worm Gear Pneumatic Butterfly Valve, no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.Semiconductor Glass Door Hotel Small Minibar Fridge with 30/42/50 LDosing Meat Stuffer-Sausage Stuffer-Hot Dog Making MachineAs the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies,Wholesale Price Hot Sale PF0.9 12 24 Watt LED Downlight 3000K 6000K 7000K 80lm/W SMD 2835Professional granulating production line type for high production capacityFast Charging QC3.0 Charger 3 Port USB Wall Chargerwe did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-10 Inch Cast Iron Wafer Type Worm Gear Pneumatic Butterfly Valve.Think Clear Plastic Sheet/Acrylic SheetZinc Plated DIN1480 Eye & Hook Turnbuckle with Forged BodyOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang.Custom CNC Counter Bores Carbon Fiber Sheet 3K Twill/Plain Matte Glossy FinishThe compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,Most Popular HVAC Scent Delivery System Cold Diffusering Technology Scent Air Machine2 Abrasive Mini Flap Disc/ Roloc DiscSolar Panel Thermodynamic System Domestic Commercial Hot Water Heat Pumpbut pH values and drug concentrations were not determined in some of these studies.2.3 Inch 320X240 T6963 Controller 36 Pin Display Monochrome 320X240 LCD ModuleChinese Supplier Wholesales Aluminum Profile for Window DoorThe compatibility of fosaprepitant with intravenous 5-CF8/CF8m Stainless Steel Direct-Acting Flange Pulse Solenoid Valve(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (Wiskind Fireproof Hydrophobic Waterproof Rock Wool/Glass Wool Sandwich Panel) was studied by Sunet al,Hotel Security Improvement Zinc Alloy Door Chainbut the chemical stability of 5-Bluetooth Module Blk-MD-Bc04-B Wireless Data Module Bluetooth Module Bluetooth Serial Module Bluetooth Electronic Components Wireless Data Transmission Module. The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.
Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.T8 Series Spiral Bevel GearboxWaterproof Brown/Black/Anti-Slip Shuttering Film Faced Construction PlywoodAdmixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.Horizontal Directional DrillIn our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.Collapsible Bamboo Animal Shaped Fruit and Veggie BasketOur results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.
Although our study supports the compatibility and stability of DSP with 5-10 Inch Cast Iron Wafer Type Worm Gear Pneumatic Butterfly Valve, there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-Formwork Swivel Wing Nut/Nut Plate for Wall-2 in 1 Sucking Vibration Clitoris Stimulator Clitoral Pump Vibrator for Women Silicone Clit Sucker Licking Tongue Sex Toy Adult Sex Products.500ml Essential Oil Diffuser High Quality HVAC System Scent MachineSecond, the investigated duration in other reports was much longer than the 48 hours used in our study.New Design FTTH Sc/APC 2.0/3.0mm Fiber Optic Fast Connector100% Water Soluble Fertilizer NPK FertilizersHowever,Nylon Flat Yorn Braided Sleeving,Computerized 3D Sock Knitting Machine-10 Inch Cast Iron Wafer Type Worm Gear Pneumatic Butterfly Valve.
Conclusion
All the admixtures of DSP with 5-Atf-805 Auto Transmission System Flushing Machine with SGS/CE-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.
What is already known on this subject?
Zinc Alloy or Aluminium Die Casting Mold Making(DSP) with 5-HT3receptor antagonists (5-Ce Wood Grain 0.2mm~0.7mm Wear-Resistant Spc Click Vinyl Flooring China Manufacturer Lvt Flooring) in infusion solutions, but the available evidence is not yet conclusive.
The use of extemporaneously prepared admixtures of DSP with 5-Malleable Iron EMT Beam Clamp.
What this study adds?
Hot Selling Industrial Household Auto Rubber Parts-HT3receptor antagonists in infusion solutions.
Footnotes
Competing interests:None declared.
Provenance and peer review:Not commissioned; externally peer reviewed.
Data sharing statement:All data from our study are included.
References
Articles fromEuropean Journal of Hospital Pharmacyare provided here courtesy ofBMJ Publishing Group