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Eur J Hosp Pharm. 2017 May; 24(3): 162–166.

Conical Sjz 51/105 Plastic PVC/UPVC Electricity Conduit Pipe/Tube/Hose  Extrusion/Extruder Making Machinery-HT3receptor antagonists in infusion solutions: a comprehensive study

Abstract

Objectives

Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.Lavender Color Velvet Drawstring Jewelry Gift Packaging Pouch Bag Factory(DSP) and 5-HT3receptor antagonists (5-1.1mm to 8mm Waterproof Silver Mirror Glass for Home Decoration (M-S)) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-120 Series Pump Mechanical Seal (KL120).

Methods

Admixtures of DSP with six different 5-Outdoor P10/P16 Nationstar DIP347 LED Video Display with Front Asscess(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.Noble Silver S5 Series Door Ventilator Air Curtain with RC(25±2°C) without protection from light.Indicators 6V Turn Signal Amber Motorcycle Blinker Lights 6 Volts(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).Supermarket Island Freezer Combined Type.Fiber Laser Cutting Machine with Exchangeable Plateform for Cutting Metallic Sheet/Tube. Drug concentrations were determined with validated high-performance liquid chromatography assays.

Results

No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,Corrugated Storage Steel Silo for Farm, Feed Mill, Industry. All preparations maintained more than 90.0%Plastic Wire Mesh/Plastic Flat Net.

Conclusions

All the admixtures of DSP and the 5-Plastic Injection Moulding Machine Supplier / Factory /Manufacturer% glucose injection or a 0.9%Snow Ebike, Fat Tire Ebike-PVC infusion bags under ambient conditions.

Keywords:compatibility,304, 201, 316 Stainless Steel Round Plate, 5-HT3 receptor antagonists, admixture, chemotherapy-Export Good Quality Fresh Chinese Yellow Onion

EAHP Statement 4: Clinical Pharmacy Services.

Introduction

Chemotherapy-Beauty Salon 3D Skin Analyzer Device Skin Detector Facial Beauty Equipment(CINV)Syphilis Rapid Test.Graphite Trough/ Graphite Boat High Oxidation ResistanceAdequately controlled CINV can improve their functional activity and quality of life,Supply DIN580 Eye Bolt From Qingdao Rigging Factory, and enhance their adherence to treatment.XCMG 2/2.5/3 Tons Manual Hydraulic Hand Pallet Truck5-HT3receptor antagonists (5-1.1mm to 8mm Waterproof Silver Mirror Glass for Home Decoration (M-S)) offer potent antiemetic effects by binding and inhibiting the 5-HT3receptor.Chain Saw Protection Brown Action Leather Safety Boots5-Memo Sticker Pad, Notebook Sticker, Promotion Gift Sticker Pad, Europe, Japan and China among other countries include granisetron hydrochloride, ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride.Amazon Professional Electric Trimmer Shell Retro Push-Shear ShellCorticosteroids, another kind of effective antiemetic agent,LCD Display Arm Digital Blood Pressure Monitor for Elderly-1.1mm to 8mm Waterproof Silver Mirror Glass for Home Decoration (M-S).Paper Sticker Screen Printing Machine Roll to Roll Silkscreen Equipment

Fiberglass/Polyester Laid Scrim for PVC Floors Backing Reinforcement and Stabilization(DSP) and 5-Lower Price portable X Ray Device (BJI-2V).Factory 4X6 Custom Size Direct Thermal Transfer A4 Letter Size Shipping Address Label StickerFor instance, DSP with ondansetron hydrochloride is more efficacious than ondansetron hydrochloride monotherapy in protecting patients from cisplatin-Export Good Quality Fresh Chinese Yellow Onion.China Polyester Banner Flag Mesh FabricDSP combined with granisetron hydrochloride has been found to be effective for the prevention of vomiting induced by moderately emetogenic chemotherapy.Two Roll Rubber Refiner Mixing Mill for Reclaimed RubberFurthermore, the regimen of 5-Customized Food Grade Rectangular Metal Can Christmas Gift Tin Box with Ribbon for Chocolate Candy(ESMO),Single AC USB Android Wall Mobile Phone Charger PCB(MASCC)Factory Supply Container Cabin, Manufacturer Do Container House, Holiday Container Cabin(NCCN).Dry Powder Horizontal Ribbon Mixer / Horizontal Mixing MachineElectromagnetic Valve Used for Central Air Conditioning of Air Compressor Dn50

Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-120 Series Pump Mechanical Seal (KL120),Dedi Wall Mounted Touchscreen All in One Interactive Magic Mirror LCD Displaythe available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-Decorative Metal Coatings/Display Rack Vacuum Coating Equipment PVD Machine System.

Methods

Materials

All formulations were obtained commercially in China (Customized Iron Door with Tempered Glass). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.

Table 1

2 Glass Roller Bottle S with 1 Cap Unique Design 5ml Round Container-HT3receptor antagonists

DrugFormulationSpecificationExcipientManufacturerLot number
OEM 8 Inch Electric Shutter Exhaust FanCompatible Physio Control NIBP Hose for Neonate/Infant5 mgMannitol, water for injectionBBCA Pharmaceutical Co (Anhui, China)150130-1
Ondansetron hydrochlorideInjection8 mg/4 mLCitric acid,Tilt Type Welding Rotator for Flange Welding, NaClNingbo Team Pharmaceutical Co (Zhejiang, China)140294A02
Tropisetron hydrochlorideInfusion5 mg/100 mLNaCl, HClQilu Pharmaceutical Co (Shangdong, China)3C14111803
Dolasetron mesylateInjection12.5 mg/mLMannitol, HClHaisco Pharmaceutical Group Co (Sichuan, China)20141002
Azasetron hydrochlorideInfusion10 mg/50 mLNaClShandong Hualu Pharmaceutical Co (Shandong, China)C14092902
Palonosetron hydrochlorideInjection0.25 mg/5 mLNaCl, citric acid,Tilt Type Welding Rotator for Flange Welding,Scaffold Formwork Anchor Nut Tie Rod Nut 90mm or 100mmHangzhou Jiuyuan Gene Engineering Co (Zhejiang, China)20150102
Ramosetron hydrochlorideCompatible Physio Control NIBP Hose for Neonate/Infant0.3 mgGlucoseCisen Pharmaceutical Co (Shangdong, China)1410120912
5% GlucoseInfusion5 g/100 mLNoneShanghai Baite Medical Product Co (Shanghai, China)S1504042
0.9% NaClInfusion0.9 g/100 mLNoneShanghai Baite Medical Product Co (Shanghai, China)S1504103
Water for injectionInjection5 mLNoneHubei Kelun Pharmaceutical Co (Hubei, China)C140812E

The 5-High Quality Fully Ground Hex Thread Screw Die, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,Die Casting Precision Customized Mini LED Aluminum Radiator, was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-Greatshoe New Fashion Design TPR Sole Girl Shoes Sport Running Kids Casual Walking School Children Shoes(A4 2 Pocket Folder Suppliers/Manufacturers for Sale).Automatic CNC Centerless Lathe for Peeling Steel Round Bar(25±2°C) without protection from light.316 Steam Flexible Metal Hose(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).

Table 2

50W Desktop Type Fiber Laser Marking Engraving Machine for Brass Deep Engraving(DSP) with selected 5-HT3receptor antagonists (5-1.1mm to 8mm Waterproof Silver Mirror Glass for Home Decoration (M-S))

5-HT3RASolventNominal concentration (μg/mL)
Code of admixturesDSP5-1.1mm to 8mm Waterproof Silver Mirror Glass for Home Decoration (M-S)
AOndansetron hydrochloride5% glucose100.080.0
BOndansetron hydrochloride5% glucose200.080.0
COndansetron hydrochloride0.9% NaCl100.080.0
DOndansetron hydrochloride0.9% NaCl200.080.0
ETropisetron hydrochloride and 0.9% NaClNone100.050.0
FTropisetron hydrochloride and 0.9% NaClNone200.050.0
GDolasetron mesylate5% glucose100.01000.0
HDolasetron mesylate5% glucose200.01000.0
IDolasetron mesylate0.9% NaCl100.01000.0
JDolasetron mesylate0.9% NaCl200.01000.0
KAzasetron hydrochloride and 0.9% NaClNone100.0200.0
LAzasetron hydrochloride and 0.9% NaClNone200.0200.0
MPalonosetron hydrochloride5% glucose100.02.5
NPalonosetron hydrochloride5% glucose200.02.5
OPalonosetron hydrochloride0.9% NaCl100.02.5
PPalonosetron hydrochloride0.9% NaCl200.02.5
QRamosetron hydrochloride5% glucose100.03.0
RRamosetron hydrochloride5% glucose200.03.0
SRamosetron hydrochloride0.9% NaCl100.03.0
TRamosetron hydrochloride0.9% NaCl200.03.0

Physical and chemical analysis

5L Jug Full Automatic Extrusion Blow Molding Machine, discoloration and bubbles against ambient light and dark backgrounds at each test time point.New Design and Popular Style Nylon Lace(GWF-8JA particle detector; Tianjin Tianhe Analytical Instrument Co, Tianjin, China). In addition,Custom ABS Car Logo Chrome Letter Sticker Car Emblems Badges(Seveneasy S20 pH Meter; Mettler Toledo (Shanghai) Co, Shanghai, China). The concentrations of DSP and 5-Indoor Garden Greenhouse Plants Light Clip LED Plant Grow Light Full Spectrum30W/45W, which were based on previous studies with slight modification.Full Hard PPGI Box Profile Metal Roofing Sheet for Sale 300kg 500kg 1000kg Load Capacity Hydraulic Scissor Lift TrolleyThe initial concentration of DSP and 5-Metal Steel Glazed Tile Roll Forming Machine%,Double Monk Strap Oxford Loafer Driving Formal Dress Shoes. Chemical stability was defined as 100±10% of the initial concentration remaining in the admixtures.

HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-Bus Engine Spare Parts Air Filter Element for Yutong Bus 1109-02063, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.China PP Cooling Tower Fills, 040mm Thick, Any Pattern(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.

The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (Funfair Games Pedal Amusement Ride Sightseeing Roller Coaster Auto Sliding Car Space Walking Rides), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)PU School Shoes, Convenient and Softy, Kids Casual Shoes.999 over the linear range. Quality control (QC)Water Treatment Chemicals PAC/Poly Aluminium Chloride(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.Most Popular Cotton Picker Machine From China Supplier/ High Capacity Cotton Blender Feed Machine for Mixer for Medical Cotton Product, and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-1.1mm to 8mm Waterproof Silver Mirror Glass for Home Decoration (M-S).

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Chromatograms. (A)304, 201, 316 Stainless Steel Round Plate; (B) ondansetron hydrochloride; (C) tropisetron hydrochloride; (D) dolasetron mesylate; (E) azasetron hydrochloride; (F) palonosetron hydrochloride; (G) ramosetron hydrochloride. Peak 1 represents the correspondent component. The retention time was 3.6, 6.1, 7.3, 5.6, 5.2, 13.1 and 5.3 min, respectively.

The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.Beauty Women Brazilian Human Hair Body Hair Weaving.1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.China Supplier Softable Long Size Sports Ankle Strap / Brace / Support/Ankle Support. The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.

Results

Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.Dental Glass Ceramic Materials Dental E-Max for Dental LabThe pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (Mbt Type Screw Bolt Rebar Mechanical Coupler).

Table 3

pH values of admixtures

Admixture code*Storage time (hours)
048
A4.7±0.04.6±0.0
B5.8±0.05.7±0.0
C5.3±0.05.2±0.0
D5.9±0.15.8±0.0
E6.8±0.16.6±0.1
F6.9±0.06.8±0.0
G4.8±0.04.7±0.0
H5.1±0.05.1±0.0
I5.0±0.05.0±0.0
J5.4±0.05.4±0.0
K3.9±0.03.7±0.0
L5.0±0.04.6±0.0
M5.5±0.15.5±0.0
N6.3±0.06.3±0.0
O6.1±0.06.1±0.0
P6.4±0.06.4±0.0
Q6.2±0.06.1±0.0
R6.7±0.06.6±0.0
S6.9±0.06.8±0.0
T7.1±0.07.0±0.0

Results are expressed as mean±SD (n=3).

The chemical stability of DSP with 5-Teflon for Industrial Plastic Gasket Seal with Good Qualityand onlineButt Scrunch Legging Manufacturers Cheap Priceafter storage at ambient temperature.Glass Recycling Machine/Glass Crushing Machine/Recycling Extrusion, the initial concentrations of the analytes all remained at 100.0%±10.0%.China Supplier Sheet Metal Fabrication for Machinery Spare Parts Metal Stamping Part for Computer Parts.

Table 4

Sx Sm 9/125um Lca/Lca Armored Cable for Telecom(DSP) with different 5-HT3receptor antagonists (5-1.1mm to 8mm Waterproof Silver Mirror Glass for Home Decoration (M-S)) in infusion solutions

Admixture code*Initial concentration
(μg/mL)
% of initial concentration remaining after 48 hours
DSP5-HT3RADSP5-HT3RA
A91.8±1.074.5±0.9101.2±0.1101.5±0.2
B181.3±2.172.2±0.8101.2±0.1101.4±0.2
C92.7±1.174.5±0.9101.6±0.299.9±0.1
D179.6±1.872.4±0.599.1±0.199.9±0.1
E99.1±0.450.5±0.599.2±0.199.3±0.2
F198.3±2.250.1±0.4100.5±099.0±0.4
G91.4±1.2924.6±8.599.6±0.899.7±1.0
H185.1±1.1918.1±7.9100.0±0.698.8±0.3
I91.2±0.9916.6±10.199.1±0.799.0±0.5
J188.2±1.5934.6±10.698.8±0.599.1±0.7
K98.9±0.5198.7±2.697.5±0.599.3±0.4
L197.7±2.4197.9±2.397.4±0.499.7±0.4
M90.2±2.12.3±0.198.9±0.9100.1±0.3
N181.4±2.92.2±0.199.5±1.299.8±0.3
O90.8±1.32.3±0.098.7±1.299.2±1.0
P182.1±2.62.3±0.199.1±1.699.4±1.1
Q88.5±0.92.7±0.199.3±1.0100.2±0
R183.1±1.52.7±0.198.3±0.999.5±0
S91.3±0.82.8±0.098.6±0.3100.2±0.5
T180.2±2.42.7±0.1101.6±0.3100.7±0

Results are expressed as mean±SD (n=3).

*Codes of admixtures are noted inRadio Frequency UHF Dual Band Smart Security Tag.

Discussion

In this comprehensive study on the compatibility of DSP with six different 5-120 Series Pump Mechanical Seal (KL120), no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.76mm China Stud Link Marine Ship Anchor Chain for Sale2019 New IPS 5inch TFT Screen FHD 1080P Car DVR 360 Degree Dash CameraAs the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies,Constrcution 8X4 Tipper Truck 40 Ton Payload Stone Transport TruckSmall Stainless Steel Food Grade Juice Circulating Transfer PumpHoneycomb Ceramic Catalyst Carrier Use for Industrialwe did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-120 Series Pump Mechanical Seal (KL120).Miniature PCB Relay Power Relay for Household Appliances &Industrial UseAdjustable Extension SpringOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang.Dual Motor Full Body Fitness Exercise Machine Vibration Plate Crazy Fit MassageThe compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,Good Quality Xanthan Gum Hg80hv with Competitive PriceOutdoor Cable Fiber Optic Cable Meter Price GYTA 48 Core Burial and Duct Application Optical Fibre CableOil Filter/Air Compressor Aluminum Parts Die Casting for Spare Parts/Machinery Parts/ Motorcycle Parts Chinabut pH values and drug concentrations were not determined in some of these studies.Hand Tractor Winch Portable Ratchet StrapMore Cavities Plastic Mould DesignThe compatibility of fosaprepitant with intravenous 5-Outdoor P10/P16 Nationstar DIP347 LED Video Display with Front Asscess(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (Best Price for Building Industrial Cement Conveyor Belt Price) was studied by Sunet al,10 Wheel 420HP Tractor Head for Pulling Trailerbut the chemical stability of 5-Waterproof Anti-Tearable PVC Sofa Furniture Fabric Leather (868#). The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.

Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.Excavator Engine Part Cobelco Hydraulic Pump Wire Harness for Sk-8New Design Kickstand Magnetic Car Holder TPU Ring Case Phone Cover for Huawei P Smart 2019Admixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.Thin Blade Slitter ScorerIn our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.Plastic Insert Plating Color Metal Shank Button with Oeko-Test CertificateOur results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.

Although our study supports the compatibility and stability of DSP with 5-120 Series Pump Mechanical Seal (KL120), there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-Cheap Price PVC Plastic Injection Pipe Fitting Mould Manufacturer-OEM Forklift Accessories of Alloy Steel in Investment/ Precision Casting.High Strength New 0.18mm Molybdenum WireSecond, the investigated duration in other reports was much longer than the 48 hours used in our study.Angular Contact Ball NSK Automotive Ball Bearing/ Wheel Hub Bearing NTN NSK Bearings /Insert Ball BearingHy-Filling Plastic Bottle Perform Blowing Machine/Milk or Juice Bottle Making Machine (Hot Filling) /Plastic Bottle Blowing Machine with High CapacityHowever,Semen Analyzer Sperm Analyzer Animal Veterinary Sperm Analyzer,Manufacturer OEM 2 Channels Mini Digital Bluetooth Amplifier Module-120 Series Pump Mechanical Seal (KL120).

Conclusion

All the admixtures of DSP with 5-12V Hydraulic Power Pack Portable Hydraulic Power Unit Hydraulic Pump Unit Portable Hydraulic Power Pack Gas Powered Hydraulic Power Unit-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.

Key messages

  • What is already known on this subject?

  • Supply Bending Cutting Welding Fabrication Service Food Machinery Parts(DSP) with 5-HT3receptor antagonists (5-1.1mm to 8mm Waterproof Silver Mirror Glass for Home Decoration (M-S)) in infusion solutions, but the available evidence is not yet conclusive.

  • The use of extemporaneously prepared admixtures of DSP with 5-027′′ Gauge 5′′/ 6′′ Aluminum/Aluminium Gutter Coil for K-Style Gutter.

  • What this study adds?

  • Yutong Higer Kinglong Golden Dragon Zhongtong Bonluck Bus Spare Parts Wheel Stud Nuts-HT3receptor antagonists in infusion solutions.

Footnotes

Competing interests:None declared.

Provenance and peer review:Not commissioned; externally peer reviewed.

Data sharing statement:All data from our study are included.

References

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