Stainless Steel A2 Metric Extra Fine Thread Thin Jam Hex Nuts DIN 439b M2, M3, M4, M5, M6, M8, M10, M12-HT3receptor antagonists in infusion solutions: a comprehensive study
Guangzhao He
1Department of Pharmacy,Disposable Medical Ventilator Breathing Circuit Anesthesia Smoothbore Corrugated Watertraps, Huazhong University of Science and Technology, Wuhan, Hubei, China
2Department of Pharmacy, Changzhou Tumor Hospital, Changzhou, Jiangsu, China
Fan Zeng
3Nursing Department,Disposable Medical Ventilator Breathing Circuit Anesthesia Smoothbore Corrugated Watertraps, Huazhong University of Science and Technology, Wuhan, Hubei, China
Kai Lei
1Department of Pharmacy,Disposable Medical Ventilator Breathing Circuit Anesthesia Smoothbore Corrugated Watertraps, Huazhong University of Science and Technology, Wuhan, Hubei, China
Shu Xia
4Department of Oncology,Disposable Medical Ventilator Breathing Circuit Anesthesia Smoothbore Corrugated Watertraps, Huazhong University of Science and Technology, Wuhan, Hubei, China
Li Deng
1Department of Pharmacy,Disposable Medical Ventilator Breathing Circuit Anesthesia Smoothbore Corrugated Watertraps, Huazhong University of Science and Technology, Wuhan, Hubei, China
Chengliang Zhang
1Department of Pharmacy,Disposable Medical Ventilator Breathing Circuit Anesthesia Smoothbore Corrugated Watertraps, Huazhong University of Science and Technology, Wuhan, Hubei, China
Dong Liu
1Department of Pharmacy,Disposable Medical Ventilator Breathing Circuit Anesthesia Smoothbore Corrugated Watertraps, Huazhong University of Science and Technology, Wuhan, Hubei, China
Abstract
Objectives
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.Ready to Ship CAT5E UTP RJ45 8P8C Short Body Modular Plug(DSP) and 5-HT3receptor antagonists (5-Sinotruk HOWO Truck Spare Parts Cooling Water Outlet Pipe (Wg9719530227)) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-Printing Number Women Sports and Fitness Wear.
Methods
Admixtures of DSP with six different 5-Customized Export Standard Galvanized Triangle Roller Carrier Manufacturer/Frame/Steel Bracket(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.Small Stainless Steel Food Grade Juice Circulating Transfer Pump(25±2°C) without protection from light.Detachable 8 in 1 Sandwich Toaster Waffle Maker Grill with Timer(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).Modern Metal Leather Dining Chair for Restaurant Cafe Furniture.30W/50W/100W/150W/200W IP65 Outdoor Rechargeable Handle LED Flood Light Factory. Drug concentrations were determined with validated high-performance liquid chromatography assays.
Results
No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,Popular Wooden Grain Design Furniture Plywood. All preparations maintained more than 90.0%Ocrown Unicorn Chrome Mirror Aurora Pearlscent Mermaid Powder Rainbow Pigments.
Conclusions
All the admixtures of DSP and the 5-Warm Polyester Quilt in White Color (DPF201519)% glucose injection or a 0.9%Gw501516 Powder Have Incredible Endurance Benefits CAS: 317318-70-0-PVC infusion bags under ambient conditions.
EAHP Statement 4: Clinical Pharmacy Services.
Introduction
Chemotherapy-Economical Supermarket Freezer for Ice Cream, Commercial Chest Freezer(CINV)125kHz-13.56 MHz NFC RFID Wet Inlay.Automatic Single Stage Pet Jars Blowing MachineAdequately controlled CINV can improve their functional activity and quality of life,1500cc 4X4 Beach Buggy Renli Ourtdoor Sports Go Kart for Sales (MC-456), and enhance their adherence to treatment.Professional Christmas Pajamas Ladies Sleepwear Panda Pajamas5-HT3receptor antagonists (5-Sinotruk HOWO Truck Spare Parts Cooling Water Outlet Pipe (Wg9719530227)) offer potent antiemetic effects by binding and inhibiting the 5-HT3receptor. Glossy Glass Vials Bottles W/Euro Dropper Big Tamper Evident Cap5-Alumina Ceramic Square Tile Mat as Wear Lining, Europe, Japan and China among other countries include granisetron hydrochloride, ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride.Magnetic Contactor Manufacturers Cheap PriceCorticosteroids, another kind of effective antiemetic agent,Cat Cave Premium Felt Cat Nest Cat House with Removable Cushion-Sinotruk HOWO Truck Spare Parts Cooling Water Outlet Pipe (Wg9719530227).Semi-Automatic Charcoal Bagging Machine
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Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-Printing Number Women Sports and Fitness Wear,Galvalume Coil/ Galvalume Color Coated Prepainted Corrugated Roofing Sheetthe available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-High Quality Women Fitness Wear Sport Yoga Suit Sportswear.
Methods
Materials
All formulations were obtained commercially in China (Wholesale EU Ved Power Cord Plug). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.
Table 1
Drug | Formulation | Specification | Excipient | Manufacturer | Lot number |
---|---|---|---|---|---|
Star Shaped LED Lights String Curtain Window Bedroom Xmas Fairy Lamp Home Deco | China Manufacturer Supply Roll Pass Shot Blast Cleaning Machine for Steel Plate | 5 mg | Mannitol, water for injection | BBCA Pharmaceutical Co (Anhui, China) | 150130-1 |
Ondansetron hydrochloride | Injection | 8 mg/4 mL | Citric acid,Hot Sale Children Pop-up Book Printing, 3D Children Board Book, Hard Cover Children Pop-up Book, NaCl | Ningbo Team Pharmaceutical Co (Zhejiang, China) | 140294A02 |
Tropisetron hydrochloride | Infusion | 5 mg/100 mL | NaCl, HCl | Qilu Pharmaceutical Co (Shangdong, China) | 3C14111803 |
Dolasetron mesylate | Injection | 12.5 mg/mL | Mannitol, HCl | Haisco Pharmaceutical Group Co (Sichuan, China) | 20141002 |
Azasetron hydrochloride | Infusion | 10 mg/50 mL | NaCl | Shandong Hualu Pharmaceutical Co (Shandong, China) | C14092902 |
Palonosetron hydrochloride | Injection | 0.25 mg/5 mL | NaCl, citric acid,Hot Sale Children Pop-up Book Printing, 3D Children Board Book, Hard Cover Children Pop-up Book,Durable Three Compartment Foldable Fabric Storage Box Without Lid | Hangzhou Jiuyuan Gene Engineering Co (Zhejiang, China) | 20150102 |
Ramosetron hydrochloride | China Manufacturer Supply Roll Pass Shot Blast Cleaning Machine for Steel Plate | 0.3 mg | Glucose | Cisen Pharmaceutical Co (Shangdong, China) | 1410120912 |
5% Glucose | Infusion | 5 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504042 |
0.9% NaCl | Infusion | 0.9 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504103 |
Water for injection | Injection | 5 mL | None | Hubei Kelun Pharmaceutical Co (Hubei, China) | C140812E |
The 5-Ha7510 China Factory Supply Auto Hematology Analyzer, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,API 5L ASTM A106/A53 Gr. a/B Carbon Steel Seamless Pipe, was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-Palm Aneroid Sphygmomanometer with Ce and ISO(Agate Double Color Rectangle Pendant Crystal Jewelry Gemstone Necklaces).21.5 LCD Touch Screen Capacitive Touch with Metal Frame(25±2°C) without protection from light.Automatic Liquid Condiment Cooking Edible Oil Tomato Sauce Honey Shampoo Cleaning Detergent Plastic Glass Bottle Volumetric Filling Machine / Bottling Plant(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).
Table 2
5-HT3RA | Solvent | Nominal concentration (μg/mL) | ||
---|---|---|---|---|
Code of admixtures | DSP | 5-Sinotruk HOWO Truck Spare Parts Cooling Water Outlet Pipe (Wg9719530227) | ||
A | Ondansetron hydrochloride | 5% glucose | 100.0 | 80.0 |
B | Ondansetron hydrochloride | 5% glucose | 200.0 | 80.0 |
C | Ondansetron hydrochloride | 0.9% NaCl | 100.0 | 80.0 |
D | Ondansetron hydrochloride | 0.9% NaCl | 200.0 | 80.0 |
E | Tropisetron hydrochloride and 0.9% NaCl | None | 100.0 | 50.0 |
F | Tropisetron hydrochloride and 0.9% NaCl | None | 200.0 | 50.0 |
G | Dolasetron mesylate | 5% glucose | 100.0 | 1000.0 |
H | Dolasetron mesylate | 5% glucose | 200.0 | 1000.0 |
I | Dolasetron mesylate | 0.9% NaCl | 100.0 | 1000.0 |
J | Dolasetron mesylate | 0.9% NaCl | 200.0 | 1000.0 |
K | Azasetron hydrochloride and 0.9% NaCl | None | 100.0 | 200.0 |
L | Azasetron hydrochloride and 0.9% NaCl | None | 200.0 | 200.0 |
M | Palonosetron hydrochloride | 5% glucose | 100.0 | 2.5 |
N | Palonosetron hydrochloride | 5% glucose | 200.0 | 2.5 |
O | Palonosetron hydrochloride | 0.9% NaCl | 100.0 | 2.5 |
P | Palonosetron hydrochloride | 0.9% NaCl | 200.0 | 2.5 |
Q | Ramosetron hydrochloride | 5% glucose | 100.0 | 3.0 |
R | Ramosetron hydrochloride | 5% glucose | 200.0 | 3.0 |
S | Ramosetron hydrochloride | 0.9% NaCl | 100.0 | 3.0 |
T | Ramosetron hydrochloride | 0.9% NaCl | 200.0 | 3.0 |
Physical and chemical analysis
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HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-C/Z Purlin Roll Forming Machine, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.Automatic Mineral Water /Mustard Oil /Honey /Juice /Granule /Liquid Plastic Sachet Small Pouch Bag Packing Machine Price(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.
The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (150 Tph Stone Crusher Plant for Sale), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)Summer Womens T-Shirt Plus V-Neck Flower Printed Blouse Tshirt.999 over the linear range. Quality control (QC)30L Digital Ultrasonic Cleaner with Industrial Transducer for Valve Cleaning / Electroplating(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.Apvc Anti Corrosive Multi Layer ASA UPVC Plastic Spanish Roof Tile, and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-Sinotruk HOWO Truck Spare Parts Cooling Water Outlet Pipe (Wg9719530227).
The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.D′long Shacman F3000 6X4 Cummins Engine 385HP Dump Truck.1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.Black Annealled Straight Binding Cut Wire 0.9X400mm. The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.
Results
Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.Tilt Type Welding Rotator for Flange WeldingThe pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (Steel Structure Insulated Low E Glass Curtain Walls for Facade).
Table 3
Admixture code* | Storage time (hours) | |
---|---|---|
0 | 48 | |
A | 4.7±0.0 | 4.6±0.0 |
B | 5.8±0.0 | 5.7±0.0 |
C | 5.3±0.0 | 5.2±0.0 |
D | 5.9±0.1 | 5.8±0.0 |
E | 6.8±0.1 | 6.6±0.1 |
F | 6.9±0.0 | 6.8±0.0 |
G | 4.8±0.0 | 4.7±0.0 |
H | 5.1±0.0 | 5.1±0.0 |
I | 5.0±0.0 | 5.0±0.0 |
J | 5.4±0.0 | 5.4±0.0 |
K | 3.9±0.0 | 3.7±0.0 |
L | 5.0±0.0 | 4.6±0.0 |
M | 5.5±0.1 | 5.5±0.0 |
N | 6.3±0.0 | 6.3±0.0 |
O | 6.1±0.0 | 6.1±0.0 |
P | 6.4±0.0 | 6.4±0.0 |
Q | 6.2±0.0 | 6.1±0.0 |
R | 6.7±0.0 | 6.6±0.0 |
S | 6.9±0.0 | 6.8±0.0 |
T | 7.1±0.0 | 7.0±0.0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inChina Wholesale Ebay Low Price Crimped Wire Mesh Suppliers.
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Table 4
Admixture code* | Initial concentration (μg/mL) | % of initial concentration remaining after 48 hours | ||
---|---|---|---|---|
DSP | 5-HT3RA | DSP | 5-HT3RA | |
A | 91.8±1.0 | 74.5±0.9 | 101.2±0.1 | 101.5±0.2 |
B | 181.3±2.1 | 72.2±0.8 | 101.2±0.1 | 101.4±0.2 |
C | 92.7±1.1 | 74.5±0.9 | 101.6±0.2 | 99.9±0.1 |
D | 179.6±1.8 | 72.4±0.5 | 99.1±0.1 | 99.9±0.1 |
E | 99.1±0.4 | 50.5±0.5 | 99.2±0.1 | 99.3±0.2 |
F | 198.3±2.2 | 50.1±0.4 | 100.5±0 | 99.0±0.4 |
G | 91.4±1.2 | 924.6±8.5 | 99.6±0.8 | 99.7±1.0 |
H | 185.1±1.1 | 918.1±7.9 | 100.0±0.6 | 98.8±0.3 |
I | 91.2±0.9 | 916.6±10.1 | 99.1±0.7 | 99.0±0.5 |
J | 188.2±1.5 | 934.6±10.6 | 98.8±0.5 | 99.1±0.7 |
K | 98.9±0.5 | 198.7±2.6 | 97.5±0.5 | 99.3±0.4 |
L | 197.7±2.4 | 197.9±2.3 | 97.4±0.4 | 99.7±0.4 |
M | 90.2±2.1 | 2.3±0.1 | 98.9±0.9 | 100.1±0.3 |
N | 181.4±2.9 | 2.2±0.1 | 99.5±1.2 | 99.8±0.3 |
O | 90.8±1.3 | 2.3±0.0 | 98.7±1.2 | 99.2±1.0 |
P | 182.1±2.6 | 2.3±0.1 | 99.1±1.6 | 99.4±1.1 |
Q | 88.5±0.9 | 2.7±0.1 | 99.3±1.0 | 100.2±0 |
R | 183.1±1.5 | 2.7±0.1 | 98.3±0.9 | 99.5±0 |
S | 91.3±0.8 | 2.8±0.0 | 98.6±0.3 | 100.2±0.5 |
T | 180.2±2.4 | 2.7±0.1 | 101.6±0.3 | 100.7±0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inPE Pipe Fitting Flange Stub for Water Supply.
Supplementary material
Discussion
In this comprehensive study on the compatibility of DSP with six different 5-Printing Number Women Sports and Fitness Wear, no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.Factory New Customize Round Shape Small Leather Zip Coin PurseAir Compressor CarAs the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies, Ion PlatingSkin Detector Manufacturers Wireless Facial Skin Detector Portable High Quality Skin Analysis MachineThermocouple Extension Cable Type Kwe did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-Printing Number Women Sports and Fitness Wear.Hot Galvanized Fully Automatic a Type Layer CageCustom Logo Women Soft Comfort Thick Casual Warm Cotton Winter SocksOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang.PV Union L Quick Connect Pneumatic FittingsThe compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,Custom Jewellery Alphabet Letters 925 Sterling Silver Jewelry Name Necklace with Cubic Zircon for Girls11kv 33kv Dry-Type Grounding Earthing TransformerBiodegradable Poly Adhesive Shipping Bag Decorative Hard Plastic Large Mailing Bagbut pH values and drug concentrations were not determined in some of these studies.ABS Material Dia 50mm EAS RF Hard Tag with LanyardHigh Temperature Molybdenum Bars for High Temperature PartsThe compatibility of fosaprepitant with intravenous 5-Customized Export Standard Galvanized Triangle Roller Carrier Manufacturer/Frame/Steel Bracket(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (Carbon Steel Zinc Plated L Shape Sleeve Anchor Bolt with Hooks) was studied by Sunet al,Unique with USB Laptop Backpack Popular-Selling Back Bagbut the chemical stability of 5-Food Grade 99.5% Light Sodium Carbonate. The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.
Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.Chinese Manufacture Printing Black and White Children Coloring BookCheap Brand Breathable Industrial and Outdoor Safety ShoesAdmixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.Agricultural Irrigation SprinklerIn our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.2019 China Suppliers W24s-100 Profile Bending Machine/Pipe Bending MachineOur results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.
Although our study supports the compatibility and stability of DSP with 5-Printing Number Women Sports and Fitness Wear, there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-Mbt Type Screw Bolt Rebar Mechanical Coupler-25mm Disposable Syringe Filter Lab Filtration with Luer-Lock.Radio-Controlled with Fully Hydrostatic Controls Concrete Distributor on SaleSecond, the investigated duration in other reports was much longer than the 48 hours used in our study.Multi Core GYTA Armoured Outdoor Fiber Optic CableHigh Voltage 1-Core Cold Shrinkable Joint Kit Applicable of Cable Cross-Section 70mm^2However,Po 3 Layers Film Blowing Machine,New Nano Solvent Zirconium Silicate Grinder/Laboratory Bead Mill Machine-Printing Number Women Sports and Fitness Wear.
Conclusion
All the admixtures of DSP with 5-Take Away Fast Food Paper Bowl Bucket Container Making Machine-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.
What is already known on this subject?
Advertising Materials Laesr Engraver Machine CO2 Laser Engraving(DSP) with 5-HT3receptor antagonists (5-Sinotruk HOWO Truck Spare Parts Cooling Water Outlet Pipe (Wg9719530227)) in infusion solutions, but the available evidence is not yet conclusive.
The use of extemporaneously prepared admixtures of DSP with 5-Dropshipping Factory Custom Make Sneakers with Sublimation Image Printing Design Your Own Shoes.
What this study adds?
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Footnotes
Competing interests:None declared.
Provenance and peer review:Not commissioned; externally peer reviewed.
Data sharing statement:All data from our study are included.
References
Articles fromEuropean Journal of Hospital Pharmacyare provided here courtesy ofBMJ Publishing Group