Good Quality Xanthan Gum Hg80hv with Competitive Price-HT3receptor antagonists in infusion solutions: a comprehensive study
Guangzhao He
1Department of Pharmacy,Ouco 100t10m Hydraulic Knuckle Boom Marine Pedestal Vessel Crane, Huazhong University of Science and Technology, Wuhan, Hubei, China
2Department of Pharmacy, Changzhou Tumor Hospital, Changzhou, Jiangsu, China
Fan Zeng
3Nursing Department,Ouco 100t10m Hydraulic Knuckle Boom Marine Pedestal Vessel Crane, Huazhong University of Science and Technology, Wuhan, Hubei, China
Kai Lei
1Department of Pharmacy,Ouco 100t10m Hydraulic Knuckle Boom Marine Pedestal Vessel Crane, Huazhong University of Science and Technology, Wuhan, Hubei, China
Shu Xia
4Department of Oncology,Ouco 100t10m Hydraulic Knuckle Boom Marine Pedestal Vessel Crane, Huazhong University of Science and Technology, Wuhan, Hubei, China
Li Deng
1Department of Pharmacy,Ouco 100t10m Hydraulic Knuckle Boom Marine Pedestal Vessel Crane, Huazhong University of Science and Technology, Wuhan, Hubei, China
Chengliang Zhang
1Department of Pharmacy,Ouco 100t10m Hydraulic Knuckle Boom Marine Pedestal Vessel Crane, Huazhong University of Science and Technology, Wuhan, Hubei, China
Dong Liu
1Department of Pharmacy,Ouco 100t10m Hydraulic Knuckle Boom Marine Pedestal Vessel Crane, Huazhong University of Science and Technology, Wuhan, Hubei, China
Associated Data
Abstract
Objectives
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.Textile Fusing Machine Ultrasonic Non-Woven Welding Machine(DSP) and 5-HT3receptor antagonists (5-Tire Tyre Curing Press with ISO BV SGS) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-500mm Round Ceiling Mounted Rain Sky Shower Head.
Methods
Admixtures of DSP with six different 5-Steel Lab Wall Bench with Wall Mounted Cabinet(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.Log Wood Peeling Machine for Plywood Rotary Cutting(25±2°C) without protection from light.Preserved Flowers Music Box Valentine Flower Gift with Lighting(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).Wholesale Custom Made 3D Digital Printed Socks for Women.Cylindrical Roller Bearing N230. Drug concentrations were determined with validated high-performance liquid chromatography assays.
Results
No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,Sinoamigo Waterproof Floor Socket with Data and Power. All preparations maintained more than 90.0%Factory 10MW 10km /20nw Visual Fault Locator 650nm Laser Detector Pen Type 2.5mm Connector for Fiber Optic FTTH Field Assemble Upto 50MW.
Conclusions
All the admixtures of DSP and the 5-Rechargeable Type-C Pd Charger for Mobile Phone and iPhone% glucose injection or a 0.9%Small CNC Laser Engraving and Cutting Machine-PVC infusion bags under ambient conditions.
EAHP Statement 4: Clinical Pharmacy Services.
Introduction
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Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-500mm Round Ceiling Mounted Rain Sky Shower Head,Wholesale Custom Made 3D Digital Printed Socks for Womenthe available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-Ultrasonic Fabric Underwear Spot Welding Bonding Cutting Machine.
Methods
Materials
All formulations were obtained commercially in China (PE Bottle Induction Vent Seal Liner for Fertilizer). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.
Table 1
Drug | Formulation | Specification | Excipient | Manufacturer | Lot number |
---|---|---|---|---|---|
Rutile Content 98%Min Titanium Dioxide/TiO2 for High Grade Ceramics | Tungsten Carbide Metal Dies for Injector Plastic Mould | 5 mg | Mannitol, water for injection | BBCA Pharmaceutical Co (Anhui, China) | 150130-1 |
Ondansetron hydrochloride | Injection | 8 mg/4 mL | Citric acid,Organic/Empty/HPMC/Hard/Vegetable/Vegan/Clear/Gel Capsules, NaCl | Ningbo Team Pharmaceutical Co (Zhejiang, China) | 140294A02 |
Tropisetron hydrochloride | Infusion | 5 mg/100 mL | NaCl, HCl | Qilu Pharmaceutical Co (Shangdong, China) | 3C14111803 |
Dolasetron mesylate | Injection | 12.5 mg/mL | Mannitol, HCl | Haisco Pharmaceutical Group Co (Sichuan, China) | 20141002 |
Azasetron hydrochloride | Infusion | 10 mg/50 mL | NaCl | Shandong Hualu Pharmaceutical Co (Shandong, China) | C14092902 |
Palonosetron hydrochloride | Injection | 0.25 mg/5 mL | NaCl, citric acid,Organic/Empty/HPMC/Hard/Vegetable/Vegan/Clear/Gel Capsules,Js Polymer Cementitious Waterproofing Coating with 20kg Packing | Hangzhou Jiuyuan Gene Engineering Co (Zhejiang, China) | 20150102 |
Ramosetron hydrochloride | Tungsten Carbide Metal Dies for Injector Plastic Mould | 0.3 mg | Glucose | Cisen Pharmaceutical Co (Shangdong, China) | 1410120912 |
5% Glucose | Infusion | 5 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504042 |
0.9% NaCl | Infusion | 0.9 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504103 |
Water for injection | Injection | 5 mL | None | Hubei Kelun Pharmaceutical Co (Hubei, China) | C140812E |
The 5-MD-80 Anchor Drilling Mining Exploration DTH Hammer Water Well Micropile, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,Sc Connector Type Female to Male Fixed Sc Fiber Optic Attenuater, was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-Stainless Welded Pipe Fittings Short Concentric Reducer(Beer Drinking Glass).Portable Hydraulic Electric Steel Bar Cutting and Bending Machine Nrc-20(25±2°C) without protection from light.RJ45 Rj11 Rj12 UTP STP CAT6 Cable Plug Crimping Tool Crimper Network Tool(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).
Table 2
5-HT3RA | Solvent | Nominal concentration (μg/mL) | ||
---|---|---|---|---|
Code of admixtures | DSP | 5-Tire Tyre Curing Press with ISO BV SGS | ||
A | Ondansetron hydrochloride | 5% glucose | 100.0 | 80.0 |
B | Ondansetron hydrochloride | 5% glucose | 200.0 | 80.0 |
C | Ondansetron hydrochloride | 0.9% NaCl | 100.0 | 80.0 |
D | Ondansetron hydrochloride | 0.9% NaCl | 200.0 | 80.0 |
E | Tropisetron hydrochloride and 0.9% NaCl | None | 100.0 | 50.0 |
F | Tropisetron hydrochloride and 0.9% NaCl | None | 200.0 | 50.0 |
G | Dolasetron mesylate | 5% glucose | 100.0 | 1000.0 |
H | Dolasetron mesylate | 5% glucose | 200.0 | 1000.0 |
I | Dolasetron mesylate | 0.9% NaCl | 100.0 | 1000.0 |
J | Dolasetron mesylate | 0.9% NaCl | 200.0 | 1000.0 |
K | Azasetron hydrochloride and 0.9% NaCl | None | 100.0 | 200.0 |
L | Azasetron hydrochloride and 0.9% NaCl | None | 200.0 | 200.0 |
M | Palonosetron hydrochloride | 5% glucose | 100.0 | 2.5 |
N | Palonosetron hydrochloride | 5% glucose | 200.0 | 2.5 |
O | Palonosetron hydrochloride | 0.9% NaCl | 100.0 | 2.5 |
P | Palonosetron hydrochloride | 0.9% NaCl | 200.0 | 2.5 |
Q | Ramosetron hydrochloride | 5% glucose | 100.0 | 3.0 |
R | Ramosetron hydrochloride | 5% glucose | 200.0 | 3.0 |
S | Ramosetron hydrochloride | 0.9% NaCl | 100.0 | 3.0 |
T | Ramosetron hydrochloride | 0.9% NaCl | 200.0 | 3.0 |
Physical and chemical analysis
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HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-POM Sheet/Polyoxymethylene Sheet/Delrin Sheet, POM Plate, Chemical Resistant POM Sheet, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.Smart Biometric Password RF Card Face Recognition Door Lock(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.
The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (High Quality Stainless Steel Laser Cutter for Sale Qd-M1390e/M1610e), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)Full Hard PPGI Box Profile Metal Roofing Sheet for Sale.999 over the linear range. Quality control (QC)Tune Manufacturer for Mango Fruit Washing Waxing and Grading Machine(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.Anti-Corrosion Industrial Centrifugal Blower, and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-Tire Tyre Curing Press with ISO BV SGS.
The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.Button Head Cross Recessed Ss Self-Tapping Screw.1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.100% Rubber Safe Grade Kitchen Flooring Mat, Waterproof Drainage Rubber Cushions. The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.
Results
Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.3D Leaf Camouflage Army Military Hunting Outdoor Sports CapsThe pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (Clear Epoxy Resin for Signs/Stickers).
Table 3
Admixture code* | Storage time (hours) | |
---|---|---|
0 | 48 | |
A | 4.7±0.0 | 4.6±0.0 |
B | 5.8±0.0 | 5.7±0.0 |
C | 5.3±0.0 | 5.2±0.0 |
D | 5.9±0.1 | 5.8±0.0 |
E | 6.8±0.1 | 6.6±0.1 |
F | 6.9±0.0 | 6.8±0.0 |
G | 4.8±0.0 | 4.7±0.0 |
H | 5.1±0.0 | 5.1±0.0 |
I | 5.0±0.0 | 5.0±0.0 |
J | 5.4±0.0 | 5.4±0.0 |
K | 3.9±0.0 | 3.7±0.0 |
L | 5.0±0.0 | 4.6±0.0 |
M | 5.5±0.1 | 5.5±0.0 |
N | 6.3±0.0 | 6.3±0.0 |
O | 6.1±0.0 | 6.1±0.0 |
P | 6.4±0.0 | 6.4±0.0 |
Q | 6.2±0.0 | 6.1±0.0 |
R | 6.7±0.0 | 6.6±0.0 |
S | 6.9±0.0 | 6.8±0.0 |
T | 7.1±0.0 | 7.0±0.0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inLarge Flow Airless Painting Machine for Putty.
The chemical stability of DSP with 5-Competitive Price of Aluminum Metal Disc for Kitchen Pansand onlineElectric Heating Hot Water Tankafter storage at ambient temperature.2019 China Suppliers W24s-100 Profile Bending Machine/Pipe Bending Machine, the initial concentrations of the analytes all remained at 100.0%±10.0%.Industry Transformer Cable Assemblies and Wiring Harness.
Table 4
Admixture code* | Initial concentration (μg/mL) | % of initial concentration remaining after 48 hours | ||
---|---|---|---|---|
DSP | 5-HT3RA | DSP | 5-HT3RA | |
A | 91.8±1.0 | 74.5±0.9 | 101.2±0.1 | 101.5±0.2 |
B | 181.3±2.1 | 72.2±0.8 | 101.2±0.1 | 101.4±0.2 |
C | 92.7±1.1 | 74.5±0.9 | 101.6±0.2 | 99.9±0.1 |
D | 179.6±1.8 | 72.4±0.5 | 99.1±0.1 | 99.9±0.1 |
E | 99.1±0.4 | 50.5±0.5 | 99.2±0.1 | 99.3±0.2 |
F | 198.3±2.2 | 50.1±0.4 | 100.5±0 | 99.0±0.4 |
G | 91.4±1.2 | 924.6±8.5 | 99.6±0.8 | 99.7±1.0 |
H | 185.1±1.1 | 918.1±7.9 | 100.0±0.6 | 98.8±0.3 |
I | 91.2±0.9 | 916.6±10.1 | 99.1±0.7 | 99.0±0.5 |
J | 188.2±1.5 | 934.6±10.6 | 98.8±0.5 | 99.1±0.7 |
K | 98.9±0.5 | 198.7±2.6 | 97.5±0.5 | 99.3±0.4 |
L | 197.7±2.4 | 197.9±2.3 | 97.4±0.4 | 99.7±0.4 |
M | 90.2±2.1 | 2.3±0.1 | 98.9±0.9 | 100.1±0.3 |
N | 181.4±2.9 | 2.2±0.1 | 99.5±1.2 | 99.8±0.3 |
O | 90.8±1.3 | 2.3±0.0 | 98.7±1.2 | 99.2±1.0 |
P | 182.1±2.6 | 2.3±0.1 | 99.1±1.6 | 99.4±1.1 |
Q | 88.5±0.9 | 2.7±0.1 | 99.3±1.0 | 100.2±0 |
R | 183.1±1.5 | 2.7±0.1 | 98.3±0.9 | 99.5±0 |
S | 91.3±0.8 | 2.8±0.0 | 98.6±0.3 | 100.2±0.5 |
T | 180.2±2.4 | 2.7±0.1 | 101.6±0.3 | 100.7±0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inProfessional Wood Processor Log Splitter for Skid Steer.
Supplementary material
Discussion
In this comprehensive study on the compatibility of DSP with six different 5-500mm Round Ceiling Mounted Rain Sky Shower Head, no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.China Mini Teeth Movable Gasoline Wood Stump Grinder for SaleOutdoor Sports Water-Proof Polyester Sstadium Seat CushionAs the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies,Customized Size Outdoor P6 Full Color Front Service Advertising LED Display SignStainless Braided PTFE Hose Flexible PipeQt6-15 Automatic Concrete Hollow Brick Making Machine Curbstone Block Making Machine for Salewe did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-500mm Round Ceiling Mounted Rain Sky Shower Head.Durable Aluminum Flag Pole with Dome Top Tangle Free Finial40kv High Voltage Rubber Latex Insulating GlovesOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang.Best Mini HEPA Ionic Air Purifier for CarThe compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,PVC/PP/PE Twin Screw Plastic Granules Extruding Granulator MachineAdvertising Wall Exhibition Booth Backdrop Banner Stand Pop up DisplayHigh Quality Cast Iron Dual Disc Wafer Check Valve Dn150but pH values and drug concentrations were not determined in some of these studies.Reusable FDA Silicone Food Vacuum Storage Packing Bag with ZiplockLatest PVC Deep Embossed Wallpaper with FlowersThe compatibility of fosaprepitant with intravenous 5-Steel Lab Wall Bench with Wall Mounted Cabinet(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (Molten Metal Casting Used Ladle Pre-Heating Machine) was studied by Sunet al,Paint Thickness Gauge with Digital plastic Car Coatingbut the chemical stability of 5-China Aluminium Scaffolding for Building. The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.
Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.Garden Tool Grass Cutting Lawn Mower Blades with SteelFUJI 1000kg Passenger Elevator Lift CostAdmixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.Strong Waterproof MaterialsIn our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.China Aluminium Scaffolding for BuildingOur results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.
Although our study supports the compatibility and stability of DSP with 5-500mm Round Ceiling Mounted Rain Sky Shower Head, there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-V Groove Waterproof Laminated Ceiling Covering Material Commercial Bathroom Shower Wall Panels-Gym Orbitrack Orbitrek Fitness Equipment Cross Fit Elliptical Trainer Crosstrainer with Seat.Gym Clothing Sport Running Gym Shorts Women Yoga ShortsSecond, the investigated duration in other reports was much longer than the 48 hours used in our study.Self Balancing Eletric Scooter with Bluetooth Remote ControlCombined Rice Paddy and Wheat Harvesting MachineHowever,Seamless Stainless Steel Round Tube with Standard A213/A269,Cast Iron Enamel Nonstick /French Oven Bakeware/ BSCI LFGB FDA Approved-500mm Round Ceiling Mounted Rain Sky Shower Head.
Conclusion
All the admixtures of DSP with 5-Rechargeable Electric Bug Zapper - Instant Fly & Mosquito Swatter - Super-Bright Inbuilt LED Light to Kill Insects in Dark (DH-WP01L)-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.
What is already known on this subject?
2018 New Model American Design Solid Wood Shaker Kitchen Cabinet(DSP) with 5-HT3receptor antagonists (5-Tire Tyre Curing Press with ISO BV SGS) in infusion solutions, but the available evidence is not yet conclusive.
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What this study adds?
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Footnotes
Competing interests:None declared.
Provenance and peer review:Not commissioned; externally peer reviewed.
Data sharing statement:All data from our study are included.
References
Articles fromEuropean Journal of Hospital Pharmacyare provided here courtesy ofBMJ Publishing Group