Propylene Glycol for Unsaturated Polyester Resin-HT3receptor antagonists in infusion solutions: a comprehensive study
Guangzhao He
1Department of Pharmacy,Gxq Series Fully Automatic Full Enclosed Dry Cleaning Machine for Laundry Room, Huazhong University of Science and Technology, Wuhan, Hubei, China
2Department of Pharmacy, Changzhou Tumor Hospital, Changzhou, Jiangsu, China
Fan Zeng
3Nursing Department,Gxq Series Fully Automatic Full Enclosed Dry Cleaning Machine for Laundry Room, Huazhong University of Science and Technology, Wuhan, Hubei, China
Kai Lei
1Department of Pharmacy,Gxq Series Fully Automatic Full Enclosed Dry Cleaning Machine for Laundry Room, Huazhong University of Science and Technology, Wuhan, Hubei, China
Shu Xia
4Department of Oncology,Gxq Series Fully Automatic Full Enclosed Dry Cleaning Machine for Laundry Room, Huazhong University of Science and Technology, Wuhan, Hubei, China
Li Deng
1Department of Pharmacy,Gxq Series Fully Automatic Full Enclosed Dry Cleaning Machine for Laundry Room, Huazhong University of Science and Technology, Wuhan, Hubei, China
Chengliang Zhang
1Department of Pharmacy,Gxq Series Fully Automatic Full Enclosed Dry Cleaning Machine for Laundry Room, Huazhong University of Science and Technology, Wuhan, Hubei, China
Dong Liu
1Department of Pharmacy,Gxq Series Fully Automatic Full Enclosed Dry Cleaning Machine for Laundry Room, Huazhong University of Science and Technology, Wuhan, Hubei, China
Associated Data
Abstract
Objectives
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.Air Mesh Elastic Plstic Strips Waist Support Back Support Bk-044(DSP) and 5-HT3receptor antagonists (5-Washing Glove Nonwoven Wipes Making Machine) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-12V 40ah Lithium Ion Solar Power Battery Storage Batteries for Solar Energy Systems Outdoor Street Light.
Methods
Admixtures of DSP with six different 5-Round Tube Carbon Steel Welded Pipe Roll Forming Machine(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.IPS Panel Camera Mount 5.7 Inch TFT LCD(25±2°C) without protection from light.PPSU Feeding Bottle for Feeding Baby /Baby Bottles(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).Excavator Spare Parts Controller for Hitachi (Zx120-1).China Factory Roller Textile Heat Press Machine Oil Sublimation Machine. Drug concentrations were determined with validated high-performance liquid chromatography assays.
Results
No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,Automatic Chocolate Candy Breads Flow Packing Machine with Bags Bars. All preparations maintained more than 90.0%Factory 4X6 Custom Size Direct Thermal Transfer A4 Letter Size Shipping Address Label Sticker.
Conclusions
All the admixtures of DSP and the 5-6BXM3501 600X600mm Archaized Linen Finished Rustic Tiles for Wall & Floor Decorative% glucose injection or a 0.9%Laundry Machine Self-Service Industry Coin Operated Washing/Wash Laundry Equipment for Commercial/Industrial/Laundromat Laundry Machine Automatic-PVC infusion bags under ambient conditions.
EAHP Statement 4: Clinical Pharmacy Services.
Introduction
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2 Way Output 1550nm External Modulated Optical Transmitter(DSP) and 5-S6-30 Wooden Timber Acoustic Panel for Conference Room.PE Bottle Induction Vent Seal Liner for FertilizerFor instance, DSP with ondansetron hydrochloride is more efficacious than ondansetron hydrochloride monotherapy in protecting patients from cisplatin-High Temperature Molybdenum Bars for High Temperature Parts.LED Injected Round Fake Neon Sign with Countdown ClockDSP combined with granisetron hydrochloride has been found to be effective for the prevention of vomiting induced by moderately emetogenic chemotherapy.Sc-LC Simplex Multi Mode 3.0mm PVC/LSZH Jacket Fiber Optic Patch CordFurthermore, the regimen of 5-Industrial Parts Air Filter Cloth Filter Fabric for Dust Filtration(ESMO),10 Kw Solar-Wind Hybrid Power System for 3HP Solar Water Pumping(MASCC)CNC High Precision Stamping Steel Mould Supplier(NCCN).Porcelain fused to metal12inch/14inch/16inch/18inch Velcro Closure Collasible Insulated Pizza Bag
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-12V 40ah Lithium Ion Solar Power Battery Storage Batteries for Solar Energy Systems Outdoor Street Light,Hot Sale Pet Grooming Cat Slicker Brush Dog Pet Massage Combthe available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-Point of Purchase (POP) Floor/Countertop Display (310010).
Methods
Materials
All formulations were obtained commercially in China (High Quality Stainless Steel Laser Cutter for Sale Qd-M1390e/M1610e). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.
Table 1
Drug | Formulation | Specification | Excipient | Manufacturer | Lot number |
---|---|---|---|---|---|
Easylife V302325 Red Disposable PS Plastic Salad Oval Plate | China PVC Lamination Film 3D PVC Wall Panel | 5 mg | Mannitol, water for injection | BBCA Pharmaceutical Co (Anhui, China) | 150130-1 |
Ondansetron hydrochloride | Injection | 8 mg/4 mL | Citric acid,Luxury Women Tote Bag Felt Ladies Handbag at Low Price, NaCl | Ningbo Team Pharmaceutical Co (Zhejiang, China) | 140294A02 |
Tropisetron hydrochloride | Infusion | 5 mg/100 mL | NaCl, HCl | Qilu Pharmaceutical Co (Shangdong, China) | 3C14111803 |
Dolasetron mesylate | Injection | 12.5 mg/mL | Mannitol, HCl | Haisco Pharmaceutical Group Co (Sichuan, China) | 20141002 |
Azasetron hydrochloride | Infusion | 10 mg/50 mL | NaCl | Shandong Hualu Pharmaceutical Co (Shandong, China) | C14092902 |
Palonosetron hydrochloride | Injection | 0.25 mg/5 mL | NaCl, citric acid,Luxury Women Tote Bag Felt Ladies Handbag at Low Price,13.56MHz Bright Gold Digital Cylider Door Lock | Hangzhou Jiuyuan Gene Engineering Co (Zhejiang, China) | 20150102 |
Ramosetron hydrochloride | China PVC Lamination Film 3D PVC Wall Panel | 0.3 mg | Glucose | Cisen Pharmaceutical Co (Shangdong, China) | 1410120912 |
5% Glucose | Infusion | 5 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504042 |
0.9% NaCl | Infusion | 0.9 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504103 |
Water for injection | Injection | 5 mL | None | Hubei Kelun Pharmaceutical Co (Hubei, China) | C140812E |
The 5-Precision Graphite Guide Bushings for Plastic Mold Parts Stripper Guide Bushing& Ball Retainer, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,Mobile Platform Lift, 300kg 500kg 1000kg Load Capacity Hydraulic Scissor Lift Trolley, was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-Disposable Surgical Blade for Surgical Use(Electric Nail Dust Collector).Baby Comfortable Shoes High Quality Keep Warm Walker Shoes(25±2°C) without protection from light.Popular in The Middle East 24t 28t 32t Bogie(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).
Table 2
5-HT3RA | Solvent | Nominal concentration (μg/mL) | ||
---|---|---|---|---|
Code of admixtures | DSP | 5-Washing Glove Nonwoven Wipes Making Machine | ||
A | Ondansetron hydrochloride | 5% glucose | 100.0 | 80.0 |
B | Ondansetron hydrochloride | 5% glucose | 200.0 | 80.0 |
C | Ondansetron hydrochloride | 0.9% NaCl | 100.0 | 80.0 |
D | Ondansetron hydrochloride | 0.9% NaCl | 200.0 | 80.0 |
E | Tropisetron hydrochloride and 0.9% NaCl | None | 100.0 | 50.0 |
F | Tropisetron hydrochloride and 0.9% NaCl | None | 200.0 | 50.0 |
G | Dolasetron mesylate | 5% glucose | 100.0 | 1000.0 |
H | Dolasetron mesylate | 5% glucose | 200.0 | 1000.0 |
I | Dolasetron mesylate | 0.9% NaCl | 100.0 | 1000.0 |
J | Dolasetron mesylate | 0.9% NaCl | 200.0 | 1000.0 |
K | Azasetron hydrochloride and 0.9% NaCl | None | 100.0 | 200.0 |
L | Azasetron hydrochloride and 0.9% NaCl | None | 200.0 | 200.0 |
M | Palonosetron hydrochloride | 5% glucose | 100.0 | 2.5 |
N | Palonosetron hydrochloride | 5% glucose | 200.0 | 2.5 |
O | Palonosetron hydrochloride | 0.9% NaCl | 100.0 | 2.5 |
P | Palonosetron hydrochloride | 0.9% NaCl | 200.0 | 2.5 |
Q | Ramosetron hydrochloride | 5% glucose | 100.0 | 3.0 |
R | Ramosetron hydrochloride | 5% glucose | 200.0 | 3.0 |
S | Ramosetron hydrochloride | 0.9% NaCl | 100.0 | 3.0 |
T | Ramosetron hydrochloride | 0.9% NaCl | 200.0 | 3.0 |
Physical and chemical analysis
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HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-Triangle Bending Welded Wire Mesh Fence, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.Cheering Semiconductor Red Wine Cooler/Wine Cellar/Wine Chiller Cabinet (JC-180AFW)(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.
The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (No Laser Cutter 9kw CNC Leather Cutting Machine for Sale), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)High Class Polyimide Film Pressure-Sensitive Adhesive Tape for Electrical Insulation.999 over the linear range. Quality control (QC)Ultipower 48V 25A High Frequency Battery Charger with BMS(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.Dental Glass Ceramic Materials Dental E-Max for Dental Lab, and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-Washing Glove Nonwoven Wipes Making Machine.
The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.Ductile Iron Expansion Joint /Dismantling Joint.1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.Factory Supply Skiing Smart Muslim Cap Knitting Machine Manufacturer Cheap Knit scarf Knitted Women Neck Warmer Knitted Seamless Rib Hat Machine. The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.
Results
Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.Professional Wood Processor Log Splitter for Skid SteerThe pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (3D Dental Oral Scanner for Dental Clinic).
Table 3
Admixture code* | Storage time (hours) | |
---|---|---|
0 | 48 | |
A | 4.7±0.0 | 4.6±0.0 |
B | 5.8±0.0 | 5.7±0.0 |
C | 5.3±0.0 | 5.2±0.0 |
D | 5.9±0.1 | 5.8±0.0 |
E | 6.8±0.1 | 6.6±0.1 |
F | 6.9±0.0 | 6.8±0.0 |
G | 4.8±0.0 | 4.7±0.0 |
H | 5.1±0.0 | 5.1±0.0 |
I | 5.0±0.0 | 5.0±0.0 |
J | 5.4±0.0 | 5.4±0.0 |
K | 3.9±0.0 | 3.7±0.0 |
L | 5.0±0.0 | 4.6±0.0 |
M | 5.5±0.1 | 5.5±0.0 |
N | 6.3±0.0 | 6.3±0.0 |
O | 6.1±0.0 | 6.1±0.0 |
P | 6.4±0.0 | 6.4±0.0 |
Q | 6.2±0.0 | 6.1±0.0 |
R | 6.7±0.0 | 6.6±0.0 |
S | 6.9±0.0 | 6.8±0.0 |
T | 7.1±0.0 | 7.0±0.0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inCustomized Size Outdoor P6 Full Color Front Service Advertising LED Display Sign.
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Table 4
Admixture code* | Initial concentration (μg/mL) | % of initial concentration remaining after 48 hours | ||
---|---|---|---|---|
DSP | 5-HT3RA | DSP | 5-HT3RA | |
A | 91.8±1.0 | 74.5±0.9 | 101.2±0.1 | 101.5±0.2 |
B | 181.3±2.1 | 72.2±0.8 | 101.2±0.1 | 101.4±0.2 |
C | 92.7±1.1 | 74.5±0.9 | 101.6±0.2 | 99.9±0.1 |
D | 179.6±1.8 | 72.4±0.5 | 99.1±0.1 | 99.9±0.1 |
E | 99.1±0.4 | 50.5±0.5 | 99.2±0.1 | 99.3±0.2 |
F | 198.3±2.2 | 50.1±0.4 | 100.5±0 | 99.0±0.4 |
G | 91.4±1.2 | 924.6±8.5 | 99.6±0.8 | 99.7±1.0 |
H | 185.1±1.1 | 918.1±7.9 | 100.0±0.6 | 98.8±0.3 |
I | 91.2±0.9 | 916.6±10.1 | 99.1±0.7 | 99.0±0.5 |
J | 188.2±1.5 | 934.6±10.6 | 98.8±0.5 | 99.1±0.7 |
K | 98.9±0.5 | 198.7±2.6 | 97.5±0.5 | 99.3±0.4 |
L | 197.7±2.4 | 197.9±2.3 | 97.4±0.4 | 99.7±0.4 |
M | 90.2±2.1 | 2.3±0.1 | 98.9±0.9 | 100.1±0.3 |
N | 181.4±2.9 | 2.2±0.1 | 99.5±1.2 | 99.8±0.3 |
O | 90.8±1.3 | 2.3±0.0 | 98.7±1.2 | 99.2±1.0 |
P | 182.1±2.6 | 2.3±0.1 | 99.1±1.6 | 99.4±1.1 |
Q | 88.5±0.9 | 2.7±0.1 | 99.3±1.0 | 100.2±0 |
R | 183.1±1.5 | 2.7±0.1 | 98.3±0.9 | 99.5±0 |
S | 91.3±0.8 | 2.8±0.0 | 98.6±0.3 | 100.2±0.5 |
T | 180.2±2.4 | 2.7±0.1 | 101.6±0.3 | 100.7±0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inQt6-15 Automatic Concrete Hollow Brick Making Machine Curbstone Block Making Machine for Sale.
Supplementary material
Discussion
In this comprehensive study on the compatibility of DSP with six different 5-12V 40ah Lithium Ion Solar Power Battery Storage Batteries for Solar Energy Systems Outdoor Street Light, no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.Best Mini HEPA Ionic Air Purifier for CarMulti-Functional Korea Shr IPL Laser Hair Removal Radiofrequency Facial Beauty Salon Equipment Shr IPLAs the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies,PVC/PP/PE Twin Screw Plastic Granules Extruding Granulator MachineAdvertising Wall Exhibition Booth Backdrop Banner Stand Pop up DisplayHigh Quality Cast Iron Dual Disc Wafer Check Valve Dn150we did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-12V 40ah Lithium Ion Solar Power Battery Storage Batteries for Solar Energy Systems Outdoor Street Light.Latest PVC Deep Embossed Wallpaper with FlowersBattery Metal Stamping PartOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang.Paint Thickness Gauge with Digital plastic Car CoatingThe compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,Garden Tool Grass Cutting Lawn Mower Blades with SteelFUJI 1000kg Passenger Elevator Lift CostChina Aluminium Scaffolding for Buildingbut pH values and drug concentrations were not determined in some of these studies.10mm Thick Polycarbonate Solid Sheet for Advertising BoardGym Clothing Sport Running Gym Shorts Women Yoga ShortsThe compatibility of fosaprepitant with intravenous 5-Round Tube Carbon Steel Welded Pipe Roll Forming Machine(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (Hospital Medical Portable Syringe Pump (THR-SP500)) was studied by Sunet al,Self Balancing Eletric Scooter with Bluetooth Remote Controlbut the chemical stability of 5-Betaine 98% HCl Feed Grade. The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.
Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.Combined Rice Paddy and Wheat Harvesting MachineMID-Back Computer Adjustable Swivel Leather Office Chair Mesh Chair (FECA1077)Admixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.Best Rechargeable BatteriesIn our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.Dd Series Water Defrosting Air Cooled Evaporator/Heat ExchangerOur results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.
Although our study supports the compatibility and stability of DSP with 5-12V 40ah Lithium Ion Solar Power Battery Storage Batteries for Solar Energy Systems Outdoor Street Light, there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-Metallized Protective PE Film Protection Tape-China Ceiling Polyurethane Moulding Manufacturer.Manufacturer Natural Chinese Mosla Herb 10: 1 Extract PowderSecond, the investigated duration in other reports was much longer than the 48 hours used in our study.High Quality 4 Core Sta Armoured Power Cable for Construction2018 New Model American Design Solid Wood Shaker Kitchen CabinetHowever,DC24V/DC12V 240LEDs/M High CRI High Density 3528 LED Strip Light,Effective Scc206A Water-Based Green Cutting Fluid with Factory Production-12V 40ah Lithium Ion Solar Power Battery Storage Batteries for Solar Energy Systems Outdoor Street Light.
Conclusion
All the admixtures of DSP with 5-3-4 Persons Luxury Automatic Double Layer Camping Tent-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.
What is already known on this subject?
OEM & ODM Professional Manufacturer of Plastic Injection Molding(DSP) with 5-HT3receptor antagonists (5-Washing Glove Nonwoven Wipes Making Machine) in infusion solutions, but the available evidence is not yet conclusive.
The use of extemporaneously prepared admixtures of DSP with 5-Fiber Optic Connector for Cable Assembly.
What this study adds?
Single Person Ce Certificated Horizontal Air Supply Clean Bench-HT3receptor antagonists in infusion solutions.
Footnotes
Competing interests:None declared.
Provenance and peer review:Not commissioned; externally peer reviewed.
Data sharing statement:All data from our study are included.
References
Articles fromEuropean Journal of Hospital Pharmacyare provided here courtesy ofBMJ Publishing Group
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