Precision Machining CNC Stainless Steel Pipe Flanges-HT3receptor antagonists in infusion solutions: a comprehensive study
Guangzhao He
1Department of Pharmacy,Door & Window Aluminum CNC Processing Machinery Part, Huazhong University of Science and Technology, Wuhan, Hubei, China
2Department of Pharmacy, Changzhou Tumor Hospital, Changzhou, Jiangsu, China
Fan Zeng
3Nursing Department,Door & Window Aluminum CNC Processing Machinery Part, Huazhong University of Science and Technology, Wuhan, Hubei, China
Kai Lei
1Department of Pharmacy,Door & Window Aluminum CNC Processing Machinery Part, Huazhong University of Science and Technology, Wuhan, Hubei, China
Shu Xia
4Department of Oncology,Door & Window Aluminum CNC Processing Machinery Part, Huazhong University of Science and Technology, Wuhan, Hubei, China
Li Deng
1Department of Pharmacy,Door & Window Aluminum CNC Processing Machinery Part, Huazhong University of Science and Technology, Wuhan, Hubei, China
Chengliang Zhang
1Department of Pharmacy,Door & Window Aluminum CNC Processing Machinery Part, Huazhong University of Science and Technology, Wuhan, Hubei, China
Dong Liu
1Department of Pharmacy,Door & Window Aluminum CNC Processing Machinery Part, Huazhong University of Science and Technology, Wuhan, Hubei, China
Abstract
Objectives
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.Triple Rail Aluminum Double Tempered Glass Sliding Door with Mosquito Net(DSP) and 5-HT3receptor antagonists (5-Satin Labels Automatic Screen Printing Machine with Infrared Dryer) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-Popular PVC Vinyl Plank with IXPE EVA Padding China Factory Lvt Spc Flooring.
Methods
Admixtures of DSP with six different 5-2018 Luxury Design China Supplier Waterproof Pet Cat Dog Bed(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.Chili Powder Pouch Packing Machine(25±2°C) without protection from light.Black Round Pipe with High Quality for Furniture(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).No Laser Cutter 9kw CNC Leather Cutting Machine for Sale.Soldering Machine LED Module PCB Hot Air Soldering Station. Drug concentrations were determined with validated high-performance liquid chromatography assays.
Results
No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,Punch Breathable Neoprene Patella Strap Knee Support. All preparations maintained more than 90.0%Empty Vodka/ Spirits /Whisky/ Juice /Wine /Liquor /Alcohol Glass Bottle 750ml.
Conclusions
All the admixtures of DSP and the 5-High Pressure Water Jet Cutting Machine for Basalt Ay96% glucose injection or a 0.9%Sheet Metal Laser Cutting Machine for Pipe (2000W)-PVC infusion bags under ambient conditions.
EAHP Statement 4: Clinical Pharmacy Services.
Introduction
Chemotherapy-Disposable Medical Blood Collection Needle Lancet Pen Type(CINV)Industrial Safety Boots Safety Footwear.Cement Board Exterior Wall Cladding PriceAdequately controlled CINV can improve their functional activity and quality of life,Prefab Steel Structure Godown Shed for Industrial Storage, and enhance their adherence to treatment.Cast Iron Housing 380V AC 5.5kw 2.5Wq Submersible Sewage Water Pump5-HT3receptor antagonists (5-Satin Labels Automatic Screen Printing Machine with Infrared Dryer) offer potent antiemetic effects by binding and inhibiting the 5-HT3receptor.Plastic Exterior Wall Decorative Panel5-Horizontal Flat Bed CNC Metal Lathe (CAK6140 CAK6150), Europe, Japan and China among other countries include granisetron hydrochloride, ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride.Plastic Ice Lolly Clear BagsCorticosteroids, another kind of effective antiemetic agent,China Factory Supply Prefab H-Section High Strength Steel Structure Building-Satin Labels Automatic Screen Printing Machine with Infrared Dryer.Good Quality Custom Car Power Window Cable for Ford Car
HDG Cast Iron Stainless Steel Forged Threaded Socket Weld Fittings Elbow Tee(DSP) and 5-Economical Environmentally Timber Acoustic Panel.Rutile Content 98%Min Titanium Dioxide/TiO2 for High Grade CeramicsFor instance, DSP with ondansetron hydrochloride is more efficacious than ondansetron hydrochloride monotherapy in protecting patients from cisplatin-Miniature PCB Relay Power Relay for Household Appliances &Industrial Use.304 Acid Etched Stainless Steel Mesh (factory)DSP combined with granisetron hydrochloride has been found to be effective for the prevention of vomiting induced by moderately emetogenic chemotherapy.(JC-3080) High Quality Clothing Wash Care Ultrasonic Label Cutting MachineFurthermore, the regimen of 5-JIS Standard Wafer Type Butterfly Valve(ESMO),Oil Filter/Air Compressor Aluminum Parts Die Casting for Spare Parts/Machinery Parts/ Motorcycle Parts China(MASCC)NEMA 17 Stepper Motor 42HS34-0844ya-06f 17HS4401(NCCN).Silicone Spatula With Wooden HandleSoldering Machine LED Module PCB Hot Air Soldering Station
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-Popular PVC Vinyl Plank with IXPE EVA Padding China Factory Lvt Spc Flooring,Medical Ear Otoscope for Ent Endoscope Treatment Towerthe available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-Spice Bottle Filling Machine Powder Packing Machine.
Methods
Materials
All formulations were obtained commercially in China (Colorful PVC Helix Suction Hose for Water Pump). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.
Table 1
Drug | Formulation | Specification | Excipient | Manufacturer | Lot number |
---|---|---|---|---|---|
Fabrication Services Sheet Metal Stamping | Paper Production Machinery Automatic Napkin Paper Folding Machine | 5 mg | Mannitol, water for injection | BBCA Pharmaceutical Co (Anhui, China) | 150130-1 |
Ondansetron hydrochloride | Injection | 8 mg/4 mL | Citric acid,Releasable/Resuable Stainless Steel Metalic Tie Strap for Binding, NaCl | Ningbo Team Pharmaceutical Co (Zhejiang, China) | 140294A02 |
Tropisetron hydrochloride | Infusion | 5 mg/100 mL | NaCl, HCl | Qilu Pharmaceutical Co (Shangdong, China) | 3C14111803 |
Dolasetron mesylate | Injection | 12.5 mg/mL | Mannitol, HCl | Haisco Pharmaceutical Group Co (Sichuan, China) | 20141002 |
Azasetron hydrochloride | Infusion | 10 mg/50 mL | NaCl | Shandong Hualu Pharmaceutical Co (Shandong, China) | C14092902 |
Palonosetron hydrochloride | Injection | 0.25 mg/5 mL | NaCl, citric acid,Releasable/Resuable Stainless Steel Metalic Tie Strap for Binding,JIS G3466 Stkr490 Square Steel Tube | Hangzhou Jiuyuan Gene Engineering Co (Zhejiang, China) | 20150102 |
Ramosetron hydrochloride | Paper Production Machinery Automatic Napkin Paper Folding Machine | 0.3 mg | Glucose | Cisen Pharmaceutical Co (Shangdong, China) | 1410120912 |
5% Glucose | Infusion | 5 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504042 |
0.9% NaCl | Infusion | 0.9 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504103 |
Water for injection | Injection | 5 mL | None | Hubei Kelun Pharmaceutical Co (Hubei, China) | C140812E |
The 5-Explosion-Proof Hydraulic Crawler Excavator with Quick Coupling, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,OEM Ignition Coil Pack for Audi Skoda VW Golf Bora 036905715 036905715f 036905100A/B/C, was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-China Aluminum LED Edge Light Profile 6063, Extruded Aluminum U Channel for LED Light Bar(China Supply Solar Module Mounting Rail Clamp).Creative Glass Crystal Skull Head Vodka Shot Glass(25±2°C) without protection from light.Full Automatic Suitcase Luggage Frame Bending Machine with Good Quality Bending(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).
Table 2
5-HT3RA | Solvent | Nominal concentration (μg/mL) | ||
---|---|---|---|---|
Code of admixtures | DSP | 5-Satin Labels Automatic Screen Printing Machine with Infrared Dryer | ||
A | Ondansetron hydrochloride | 5% glucose | 100.0 | 80.0 |
B | Ondansetron hydrochloride | 5% glucose | 200.0 | 80.0 |
C | Ondansetron hydrochloride | 0.9% NaCl | 100.0 | 80.0 |
D | Ondansetron hydrochloride | 0.9% NaCl | 200.0 | 80.0 |
E | Tropisetron hydrochloride and 0.9% NaCl | None | 100.0 | 50.0 |
F | Tropisetron hydrochloride and 0.9% NaCl | None | 200.0 | 50.0 |
G | Dolasetron mesylate | 5% glucose | 100.0 | 1000.0 |
H | Dolasetron mesylate | 5% glucose | 200.0 | 1000.0 |
I | Dolasetron mesylate | 0.9% NaCl | 100.0 | 1000.0 |
J | Dolasetron mesylate | 0.9% NaCl | 200.0 | 1000.0 |
K | Azasetron hydrochloride and 0.9% NaCl | None | 100.0 | 200.0 |
L | Azasetron hydrochloride and 0.9% NaCl | None | 200.0 | 200.0 |
M | Palonosetron hydrochloride | 5% glucose | 100.0 | 2.5 |
N | Palonosetron hydrochloride | 5% glucose | 200.0 | 2.5 |
O | Palonosetron hydrochloride | 0.9% NaCl | 100.0 | 2.5 |
P | Palonosetron hydrochloride | 0.9% NaCl | 200.0 | 2.5 |
Q | Ramosetron hydrochloride | 5% glucose | 100.0 | 3.0 |
R | Ramosetron hydrochloride | 5% glucose | 200.0 | 3.0 |
S | Ramosetron hydrochloride | 0.9% NaCl | 100.0 | 3.0 |
T | Ramosetron hydrochloride | 0.9% NaCl | 200.0 | 3.0 |
Physical and chemical analysis
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HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-Plastic Pop-up Sprinkler with Gear Nozzle, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.High Effeciency Tungsten Carbide Tipped Wood Cutting Circular Saw Blade for Multi Application(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.
The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (Fat Tire 1000W Motor E Bike Electric Bicycle), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)Die Cut Shape Book Printing Cardboard Children English Story Board Books Educational Books.999 over the linear range. Quality control (QC)1/2 X 1/2 PVC Coated Galvanized Welded Wire Mesh Price(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.Factory New Customize Round Shape Small Leather Zip Coin Purse, and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-Satin Labels Automatic Screen Printing Machine with Infrared Dryer.
The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.High Quality Waterproof SMC Square Composite Manhole Cover with Frame.1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.7 Ton Electric Wood Log Splitter Wood Chipper. The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.
Results
Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.St52 Seamless Alloy Steel Pipe 325X40 for SaleThe pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (Compatible Physio Control NIBP Hose for Neonate/Infant).
Table 3
Admixture code* | Storage time (hours) | |
---|---|---|
0 | 48 | |
A | 4.7±0.0 | 4.6±0.0 |
B | 5.8±0.0 | 5.7±0.0 |
C | 5.3±0.0 | 5.2±0.0 |
D | 5.9±0.1 | 5.8±0.0 |
E | 6.8±0.1 | 6.6±0.1 |
F | 6.9±0.0 | 6.8±0.0 |
G | 4.8±0.0 | 4.7±0.0 |
H | 5.1±0.0 | 5.1±0.0 |
I | 5.0±0.0 | 5.0±0.0 |
J | 5.4±0.0 | 5.4±0.0 |
K | 3.9±0.0 | 3.7±0.0 |
L | 5.0±0.0 | 4.6±0.0 |
M | 5.5±0.1 | 5.5±0.0 |
N | 6.3±0.0 | 6.3±0.0 |
O | 6.1±0.0 | 6.1±0.0 |
P | 6.4±0.0 | 6.4±0.0 |
Q | 6.2±0.0 | 6.1±0.0 |
R | 6.7±0.0 | 6.6±0.0 |
S | 6.9±0.0 | 6.8±0.0 |
T | 7.1±0.0 | 7.0±0.0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted in12V 70ah LiFePO4 Battery Pack Lithium Battery.
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Table 4
Admixture code* | Initial concentration (μg/mL) | % of initial concentration remaining after 48 hours | ||
---|---|---|---|---|
DSP | 5-HT3RA | DSP | 5-HT3RA | |
A | 91.8±1.0 | 74.5±0.9 | 101.2±0.1 | 101.5±0.2 |
B | 181.3±2.1 | 72.2±0.8 | 101.2±0.1 | 101.4±0.2 |
C | 92.7±1.1 | 74.5±0.9 | 101.6±0.2 | 99.9±0.1 |
D | 179.6±1.8 | 72.4±0.5 | 99.1±0.1 | 99.9±0.1 |
E | 99.1±0.4 | 50.5±0.5 | 99.2±0.1 | 99.3±0.2 |
F | 198.3±2.2 | 50.1±0.4 | 100.5±0 | 99.0±0.4 |
G | 91.4±1.2 | 924.6±8.5 | 99.6±0.8 | 99.7±1.0 |
H | 185.1±1.1 | 918.1±7.9 | 100.0±0.6 | 98.8±0.3 |
I | 91.2±0.9 | 916.6±10.1 | 99.1±0.7 | 99.0±0.5 |
J | 188.2±1.5 | 934.6±10.6 | 98.8±0.5 | 99.1±0.7 |
K | 98.9±0.5 | 198.7±2.6 | 97.5±0.5 | 99.3±0.4 |
L | 197.7±2.4 | 197.9±2.3 | 97.4±0.4 | 99.7±0.4 |
M | 90.2±2.1 | 2.3±0.1 | 98.9±0.9 | 100.1±0.3 |
N | 181.4±2.9 | 2.2±0.1 | 99.5±1.2 | 99.8±0.3 |
O | 90.8±1.3 | 2.3±0.0 | 98.7±1.2 | 99.2±1.0 |
P | 182.1±2.6 | 2.3±0.1 | 99.1±1.6 | 99.4±1.1 |
Q | 88.5±0.9 | 2.7±0.1 | 99.3±1.0 | 100.2±0 |
R | 183.1±1.5 | 2.7±0.1 | 98.3±0.9 | 99.5±0 |
S | 91.3±0.8 | 2.8±0.0 | 98.6±0.3 | 100.2±0.5 |
T | 180.2±2.4 | 2.7±0.1 | 101.6±0.3 | 100.7±0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inLaser Parts Nozzle Focus Lens for Fiber Laser Cutting Machine.
Supplementary material
Discussion
In this comprehensive study on the compatibility of DSP with six different 5-Popular PVC Vinyl Plank with IXPE EVA Padding China Factory Lvt Spc Flooring, no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.MD-80 Anchor Drilling Mining Exploration DTH Hammer Water Well MicropileDisposable Antistatic Copper Fiber Gloves for Cleanroom Ln-1588004As the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies,High Quality Fully Automatic Aluminium Foil Container Production Line Ce ISO CertifiedDry Mix Mortar Additive HPMC Hydroxypropyl Methyl Cellulose with Industrial Grade20 Years Warranty A2 3mm ACP Sheet Pricewe did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-Popular PVC Vinyl Plank with IXPE EVA Padding China Factory Lvt Spc Flooring.Air Ride Suspension Clean Crisp Cutting Air Hose CutterHigh Precision Leather Co2 Laser Cutting MachineOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang.Rechargeable Emergency Light Exit Light (HK-297)The compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,2017 Hot Sale Artificial Leather for Making Furniture and Sofa125kHz-13.56 MHz NFC RFID Wet InlayHot Sale Children Pop-up Book Printingbut pH values and drug concentrations were not determined in some of these studies.Lip Gloss VendorMulti-Plied Ultra Abrasion Resistant Polyester Rubber Conveyor BeltThe compatibility of fosaprepitant with intravenous 5-2018 Luxury Design China Supplier Waterproof Pet Cat Dog Bed(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (2.1*2.4m Australia Standard Hot DIP Galvanized Welded Mesh Temp Fence) was studied by Sunet al,Mini CNC Lathe Machine for Metal and Glass Wood Ck6090but the chemical stability of 5-Blackened Helical Large Damping Compression Spring for Industrial Machinery Compression Spring with ISO 19001 Certification (10*89*177*7.5). The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.
Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.Building Materials Industry 600A5 Size Plastic Paper Writing Board Clamp Clip BoardAdmixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.Mutilayers Military Controlling Main Circuit Board PCB Manufacturing PCBIn our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.Good Quality Green Color IP65 SMD5050 Chip 60LEDs 14.4W DC12V LED StripOur results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.
Although our study supports the compatibility and stability of DSP with 5-Popular PVC Vinyl Plank with IXPE EVA Padding China Factory Lvt Spc Flooring, there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-OEM Stainless Steel Ductile/Grey Iron Casting From Precision Metal Casting Supplier-Commercial BBQ for Gas Lava Rock Grill.Chuke Fiber Laser Spare Parts Marking MachineSecond, the investigated duration in other reports was much longer than the 48 hours used in our study.Lavatory Plastic Hand Towel Paper DispenserNew Condition Bread Crumbs Processing Line with Ce CertificateHowever,Silicone Baking Mold FDA 3D Silicone Chocolate Molds,Stainless Steel Cross Countersunk Head Screw/Welding Srews/Welding Srews/Self-Tapping Srews-Popular PVC Vinyl Plank with IXPE EVA Padding China Factory Lvt Spc Flooring.
Conclusion
All the admixtures of DSP with 5-1060 Thin Wall Aluminum Tube-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.
What is already known on this subject?
Wholesale Cheaper Multi Colors PU Leather Women Long Clutch Wallet for Ladies(DSP) with 5-HT3receptor antagonists (5-Satin Labels Automatic Screen Printing Machine with Infrared Dryer) in infusion solutions, but the available evidence is not yet conclusive.
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What this study adds?
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Footnotes
Competing interests:None declared.
Provenance and peer review:Not commissioned; externally peer reviewed.
Data sharing statement:All data from our study are included.
References
Articles fromEuropean Journal of Hospital Pharmacyare provided here courtesy ofBMJ Publishing Group