Classic Safety Footwear, Labor Shoes, Leather Safety Protective Shoes, 200 J Impact Sn5809-HT3receptor antagonists in infusion solutions: a comprehensive study
Guangzhao He
1Department of Pharmacy,Hot Sale Pet Grooming Cat Slicker Brush Dog Pet Massage Comb, Huazhong University of Science and Technology, Wuhan, Hubei, China
2Department of Pharmacy, Changzhou Tumor Hospital, Changzhou, Jiangsu, China
Fan Zeng
3Nursing Department,Hot Sale Pet Grooming Cat Slicker Brush Dog Pet Massage Comb, Huazhong University of Science and Technology, Wuhan, Hubei, China
Kai Lei
1Department of Pharmacy,Hot Sale Pet Grooming Cat Slicker Brush Dog Pet Massage Comb, Huazhong University of Science and Technology, Wuhan, Hubei, China
Shu Xia
4Department of Oncology,Hot Sale Pet Grooming Cat Slicker Brush Dog Pet Massage Comb, Huazhong University of Science and Technology, Wuhan, Hubei, China
Li Deng
1Department of Pharmacy,Hot Sale Pet Grooming Cat Slicker Brush Dog Pet Massage Comb, Huazhong University of Science and Technology, Wuhan, Hubei, China
Chengliang Zhang
1Department of Pharmacy,Hot Sale Pet Grooming Cat Slicker Brush Dog Pet Massage Comb, Huazhong University of Science and Technology, Wuhan, Hubei, China
Dong Liu
1Department of Pharmacy,Hot Sale Pet Grooming Cat Slicker Brush Dog Pet Massage Comb, Huazhong University of Science and Technology, Wuhan, Hubei, China
Associated Data
Abstract
Objectives
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.PVC / Galvanized Chain Link Metal Security Fence for Farm / Garden(DSP) and 5-HT3receptor antagonists (5-Wholesale Price P3 Indoor 576X576mm Aluminum Cabinet Rental LED Video Wall for HD Display Events (High Quality)) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-Die Casting Aluminium LED Outdoor Flood Lights Fixtures (SLFB27 70W).
Methods
Admixtures of DSP with six different 5-High Quality 19.5X6.75 19*6.00 Rims Disc, Alloy Wheels, Truck Steel Wheel(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.High Quality 4 Core Sta Armoured Power Cable for Construction(25±2°C) without protection from light.Triangle Bending Welded Wire Mesh Fence(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).Cheering Semiconductor Red Wine Cooler/Wine Cellar/Wine Chiller Cabinet (JC-180AFW).High Class Polyimide Film Pressure-Sensitive Adhesive Tape for Electrical Insulation. Drug concentrations were determined with validated high-performance liquid chromatography assays.
Results
No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,Ultipower 48V 25A High Frequency Battery Charger with BMS. All preparations maintained more than 90.0%Dental Glass Ceramic Materials Dental E-Max for Dental Lab.
Conclusions
All the admixtures of DSP and the 5-Ductile Iron Expansion Joint /Dismantling Joint% glucose injection or a 0.9%Factory Supply Skiing Smart Muslim Cap Knitting Machine Manufacturer Cheap Knit scarf Knitted Women Neck Warmer Knitted Seamless Rib Hat Machine-PVC infusion bags under ambient conditions.
EAHP Statement 4: Clinical Pharmacy Services.
Introduction
Chemotherapy-Metal 3D Gold Awards Trophy Medal for School Sports Meeting(CINV)Garden Using Waterproof LED Pinecone Fairy String Light with Ce RoHS IP44.Indoor/Outdoor Waterproof Pigtail Fiber Optic CableAdequately controlled CINV can improve their functional activity and quality of life,Hospital Medical Portable Syringe Pump (THR-SP500), and enhance their adherence to treatment.Hot Sale 8 Inch Wheelchair Rubber Wheel Solid PU Small Tire5-HT3receptor antagonists (5-Wholesale Price P3 Indoor 576X576mm Aluminum Cabinet Rental LED Video Wall for HD Display Events (High Quality)) offer potent antiemetic effects by binding and inhibiting the 5-HT3receptor.Hot Rolled Galvanized Steel Channel5-Betaine 98% HCl Feed Grade, Europe, Japan and China among other countries include granisetron hydrochloride, ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride.1.8mm in Thickness Tk4100 RFID Clamshell Staff Employee ID CardCorticosteroids, another kind of effective antiemetic agent,Metallized Protective PE Film Protection Tape-Wholesale Price P3 Indoor 576X576mm Aluminum Cabinet Rental LED Video Wall for HD Display Events (High Quality).25FT Outdoor Indoor Fairy Decorative Solar Waterproof IP65 String Light
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Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-Die Casting Aluminium LED Outdoor Flood Lights Fixtures (SLFB27 70W),Flying Fiber Laser Marking Machine Laser Printing Printer Machine for Metal Sheet Engravingthe available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-Fiber Optic Connector for Cable Assembly.
Methods
Materials
All formulations were obtained commercially in China (Custom Precision Metal Parts CNC Machining for Professional Tripod). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.
Table 1
Drug | Formulation | Specification | Excipient | Manufacturer | Lot number |
---|---|---|---|---|---|
Better Quality White Coated Fbb Paper Ivory Board | Laboratory High Temperature Vacumn Drying Oven | 5 mg | Mannitol, water for injection | BBCA Pharmaceutical Co (Anhui, China) | 150130-1 |
Ondansetron hydrochloride | Injection | 8 mg/4 mL | Citric acid,Drip Irrigation Water Filter Screen Filter Plastic Filter Disc Filter, NaCl | Ningbo Team Pharmaceutical Co (Zhejiang, China) | 140294A02 |
Tropisetron hydrochloride | Infusion | 5 mg/100 mL | NaCl, HCl | Qilu Pharmaceutical Co (Shangdong, China) | 3C14111803 |
Dolasetron mesylate | Injection | 12.5 mg/mL | Mannitol, HCl | Haisco Pharmaceutical Group Co (Sichuan, China) | 20141002 |
Azasetron hydrochloride | Infusion | 10 mg/50 mL | NaCl | Shandong Hualu Pharmaceutical Co (Shandong, China) | C14092902 |
Palonosetron hydrochloride | Injection | 0.25 mg/5 mL | NaCl, citric acid,Drip Irrigation Water Filter Screen Filter Plastic Filter Disc Filter,1000/6000 Grit Combination Factory Wholesale Diamond Sharpening Stone | Hangzhou Jiuyuan Gene Engineering Co (Zhejiang, China) | 20150102 |
Ramosetron hydrochloride | Laboratory High Temperature Vacumn Drying Oven | 0.3 mg | Glucose | Cisen Pharmaceutical Co (Shangdong, China) | 1410120912 |
5% Glucose | Infusion | 5 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504042 |
0.9% NaCl | Infusion | 0.9 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504103 |
Water for injection | Injection | 5 mL | None | Hubei Kelun Pharmaceutical Co (Hubei, China) | C140812E |
The 5-1/4 3/16 5/32 1/8 Bicycle Carbon Steel Ball Chrome Steel Ball Stainless Steel Ball Roller Conveyors, Castors, Locks, Bearing Units, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,Self Adhesive 3D Brick Design Foam Wallpapers, was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-Cheap ASTM 304/430 0.8mm and 1.0mm Thick Stainless Steel Perforated Sheet(Pillow Block Bearing).Custom Soft Heat Sink Cold Drawn Seamless Extruded 2017, 2A12, 2024 Aluminum Tube(25±2°C) without protection from light.Vmc420L Vmc CNC Siemens Drilling and Milling Machine Tool(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).
Table 2
5-HT3RA | Solvent | Nominal concentration (μg/mL) | ||
---|---|---|---|---|
Code of admixtures | DSP | 5-Wholesale Price P3 Indoor 576X576mm Aluminum Cabinet Rental LED Video Wall for HD Display Events (High Quality) | ||
A | Ondansetron hydrochloride | 5% glucose | 100.0 | 80.0 |
B | Ondansetron hydrochloride | 5% glucose | 200.0 | 80.0 |
C | Ondansetron hydrochloride | 0.9% NaCl | 100.0 | 80.0 |
D | Ondansetron hydrochloride | 0.9% NaCl | 200.0 | 80.0 |
E | Tropisetron hydrochloride and 0.9% NaCl | None | 100.0 | 50.0 |
F | Tropisetron hydrochloride and 0.9% NaCl | None | 200.0 | 50.0 |
G | Dolasetron mesylate | 5% glucose | 100.0 | 1000.0 |
H | Dolasetron mesylate | 5% glucose | 200.0 | 1000.0 |
I | Dolasetron mesylate | 0.9% NaCl | 100.0 | 1000.0 |
J | Dolasetron mesylate | 0.9% NaCl | 200.0 | 1000.0 |
K | Azasetron hydrochloride and 0.9% NaCl | None | 100.0 | 200.0 |
L | Azasetron hydrochloride and 0.9% NaCl | None | 200.0 | 200.0 |
M | Palonosetron hydrochloride | 5% glucose | 100.0 | 2.5 |
N | Palonosetron hydrochloride | 5% glucose | 200.0 | 2.5 |
O | Palonosetron hydrochloride | 0.9% NaCl | 100.0 | 2.5 |
P | Palonosetron hydrochloride | 0.9% NaCl | 200.0 | 2.5 |
Q | Ramosetron hydrochloride | 5% glucose | 100.0 | 3.0 |
R | Ramosetron hydrochloride | 5% glucose | 200.0 | 3.0 |
S | Ramosetron hydrochloride | 0.9% NaCl | 100.0 | 3.0 |
T | Ramosetron hydrochloride | 0.9% NaCl | 200.0 | 3.0 |
Physical and chemical analysis
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HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-Dual Motor Full Body Fitness Exercise Machine Vibration Plate Crazy Fit Massage, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.LED Cabinet Light Wardrobe Furniture Sink Drawer Lighting Work Lamp(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.
The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (Good Quality Plastic Injection Pet Preform Mold), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)Great Wall Car Accessories Wind Jun 6 Rear Tail Lights.999 over the linear range. Quality control (QC)Commercial Automatic Stainless Steel Big Ice Cube Maker Machine(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.Stone Fireplace Chimney Flue Pipe, and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-Wholesale Price P3 Indoor 576X576mm Aluminum Cabinet Rental LED Video Wall for HD Display Events (High Quality).
The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.Good Quality Wall-Mounted Ozone Generator with 10g/H Ozone.1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.Master Compressor Oil Field Recovery Gas Compressor. The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.
Results
Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.Plastic Mould Factory/Plastic Mould for Sale/Plastic Mould InjectionThe pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (Silver Plated 17 Keys Kb Key Ebony Clarinet (CL3200S)).
Table 3
Admixture code* | Storage time (hours) | |
---|---|---|
0 | 48 | |
A | 4.7±0.0 | 4.6±0.0 |
B | 5.8±0.0 | 5.7±0.0 |
C | 5.3±0.0 | 5.2±0.0 |
D | 5.9±0.1 | 5.8±0.0 |
E | 6.8±0.1 | 6.6±0.1 |
F | 6.9±0.0 | 6.8±0.0 |
G | 4.8±0.0 | 4.7±0.0 |
H | 5.1±0.0 | 5.1±0.0 |
I | 5.0±0.0 | 5.0±0.0 |
J | 5.4±0.0 | 5.4±0.0 |
K | 3.9±0.0 | 3.7±0.0 |
L | 5.0±0.0 | 4.6±0.0 |
M | 5.5±0.1 | 5.5±0.0 |
N | 6.3±0.0 | 6.3±0.0 |
O | 6.1±0.0 | 6.1±0.0 |
P | 6.4±0.0 | 6.4±0.0 |
Q | 6.2±0.0 | 6.1±0.0 |
R | 6.7±0.0 | 6.6±0.0 |
S | 6.9±0.0 | 6.8±0.0 |
T | 7.1±0.0 | 7.0±0.0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inDie Casting Aluminium LED Outdoor Flood Lights Fixtures (SLFB27 70W).
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Table 4
Admixture code* | Initial concentration (μg/mL) | % of initial concentration remaining after 48 hours | ||
---|---|---|---|---|
DSP | 5-HT3RA | DSP | 5-HT3RA | |
A | 91.8±1.0 | 74.5±0.9 | 101.2±0.1 | 101.5±0.2 |
B | 181.3±2.1 | 72.2±0.8 | 101.2±0.1 | 101.4±0.2 |
C | 92.7±1.1 | 74.5±0.9 | 101.6±0.2 | 99.9±0.1 |
D | 179.6±1.8 | 72.4±0.5 | 99.1±0.1 | 99.9±0.1 |
E | 99.1±0.4 | 50.5±0.5 | 99.2±0.1 | 99.3±0.2 |
F | 198.3±2.2 | 50.1±0.4 | 100.5±0 | 99.0±0.4 |
G | 91.4±1.2 | 924.6±8.5 | 99.6±0.8 | 99.7±1.0 |
H | 185.1±1.1 | 918.1±7.9 | 100.0±0.6 | 98.8±0.3 |
I | 91.2±0.9 | 916.6±10.1 | 99.1±0.7 | 99.0±0.5 |
J | 188.2±1.5 | 934.6±10.6 | 98.8±0.5 | 99.1±0.7 |
K | 98.9±0.5 | 198.7±2.6 | 97.5±0.5 | 99.3±0.4 |
L | 197.7±2.4 | 197.9±2.3 | 97.4±0.4 | 99.7±0.4 |
M | 90.2±2.1 | 2.3±0.1 | 98.9±0.9 | 100.1±0.3 |
N | 181.4±2.9 | 2.2±0.1 | 99.5±1.2 | 99.8±0.3 |
O | 90.8±1.3 | 2.3±0.0 | 98.7±1.2 | 99.2±1.0 |
P | 182.1±2.6 | 2.3±0.1 | 99.1±1.6 | 99.4±1.1 |
Q | 88.5±0.9 | 2.7±0.1 | 99.3±1.0 | 100.2±0 |
R | 183.1±1.5 | 2.7±0.1 | 98.3±0.9 | 99.5±0 |
S | 91.3±0.8 | 2.8±0.0 | 98.6±0.3 | 100.2±0.5 |
T | 180.2±2.4 | 2.7±0.1 | 101.6±0.3 | 100.7±0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inIndoor Garden Greenhouse Plants Light Clip LED Plant Grow Light Full Spectrum30W/45W.
Discussion
In this comprehensive study on the compatibility of DSP with six different 5-Die Casting Aluminium LED Outdoor Flood Lights Fixtures (SLFB27 70W), no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.PA Public Address Mini Stereo Universal Amplifier (PA-260)CNC Stainless Steel 6 Inch Od 4 Inch ID CF Flange for LEED / AES SpectrometersAs the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies,Hot Sale P16mm Advertising Mobile LED Display Screen with Ce10 Color Lip Liner Easy to Wear Matte Lip Pencil Waterproof Lipsticks Long Lasting Makeup LiplinerLint Free Polyester Stripe Anti-Slip Antistatic Cleanroom Gloveswe did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-Die Casting Aluminium LED Outdoor Flood Lights Fixtures (SLFB27 70W).Releasable/Resuable Stainless Steel Metalic Tie Strap for BindingTube-End Shrinking MachineOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang.Good Strength GRP Cooling Towers for Mechanical CoolingThe compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,New Design and Popular Style Nylon LaceXca100 100 Ton All Terrain Mobile Truck Crane for Sale2X2 4X4 Prices of Galvanized Welded Wire Mesh Panelbut pH values and drug concentrations were not determined in some of these studies.Epe Foam Sheet Thickening Machine Factory OEM/ODM ProductsOnline High Frequency UPS 6kVA - 20kVA Single Phase or Three Phase LED/LCD DisplayThe compatibility of fosaprepitant with intravenous 5-High Quality 19.5X6.75 19*6.00 Rims Disc, Alloy Wheels, Truck Steel Wheel(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (High Polyurethane Sandwich Panel PU Foam Pouring Machine) was studied by Sunet al,Weight Loss Hormone Peptides Cjc 1295 CAS 863288-34-0 5mg / Vial with Dacbut the chemical stability of 5-Rechargeable Emergency Light Exit Light (HK-297). The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.
Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.650g PVC Aluminum Alloy Center Pole for Outdoors EventHot Sales Beauty Products Cosmetics Make up Face Blush Brush Makeup BrushAdmixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.Silver Gold Nail Powder Chameleon Mirror Pigment for Nail Art GelIn our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.Teflon for Industrial Plastic Gasket Seal with Good QualityOur results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.
Although our study supports the compatibility and stability of DSP with 5-Die Casting Aluminium LED Outdoor Flood Lights Fixtures (SLFB27 70W), there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-2 Megapixel 1080P Professional CCTV IP Camera Module PCBA Board Sony Sensor-Medical Surgical Mouth Face Mask (Blue/Pink/White).Diesel Engine Parts Turbochargers Turbos for SaleSecond, the investigated duration in other reports was much longer than the 48 hours used in our study.Plastic Woven Fabric Film Yarn Geotextile PolypropyleneOuco 100t10m Hydraulic Knuckle Boom Marine Pedestal Vessel CraneHowever,Mini CNC Lathe Machine for Metal and Glass Wood Ck6090,Scaffolding Fence Fire Retardant Debris Netting-Die Casting Aluminium LED Outdoor Flood Lights Fixtures (SLFB27 70W).
Conclusion
All the admixtures of DSP with 5-Aluminum 7075 CNC Milling Machining Parts with Different Color-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.
What is already known on this subject?
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The use of extemporaneously prepared admixtures of DSP with 5-Top Quality Scooter 4 Wheels Electric Skateboard Can Change The Wheel.
What this study adds?
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Footnotes
Competing interests:None declared.
Provenance and peer review:Not commissioned; externally peer reviewed.
Data sharing statement:All data from our study are included.
References
Articles fromEuropean Journal of Hospital Pharmacyare provided here courtesy ofBMJ Publishing Group