Heat Sealing Aluminum Foil Laminated Woven Fabric-HT3receptor antagonists in infusion solutions: a comprehensive study
Guangzhao He
1Department of Pharmacy,P4.81 250X250 Indoor Rental LED Display Modules for Event Rental LED Display High Refresh LED Display Module, Huazhong University of Science and Technology, Wuhan, Hubei, China
2Department of Pharmacy, Changzhou Tumor Hospital, Changzhou, Jiangsu, China
Fan Zeng
3Nursing Department,P4.81 250X250 Indoor Rental LED Display Modules for Event Rental LED Display High Refresh LED Display Module, Huazhong University of Science and Technology, Wuhan, Hubei, China
Kai Lei
1Department of Pharmacy,P4.81 250X250 Indoor Rental LED Display Modules for Event Rental LED Display High Refresh LED Display Module, Huazhong University of Science and Technology, Wuhan, Hubei, China
Shu Xia
4Department of Oncology,P4.81 250X250 Indoor Rental LED Display Modules for Event Rental LED Display High Refresh LED Display Module, Huazhong University of Science and Technology, Wuhan, Hubei, China
Li Deng
1Department of Pharmacy,P4.81 250X250 Indoor Rental LED Display Modules for Event Rental LED Display High Refresh LED Display Module, Huazhong University of Science and Technology, Wuhan, Hubei, China
Chengliang Zhang
1Department of Pharmacy,P4.81 250X250 Indoor Rental LED Display Modules for Event Rental LED Display High Refresh LED Display Module, Huazhong University of Science and Technology, Wuhan, Hubei, China
Dong Liu
1Department of Pharmacy,P4.81 250X250 Indoor Rental LED Display Modules for Event Rental LED Display High Refresh LED Display Module, Huazhong University of Science and Technology, Wuhan, Hubei, China
Associated Data
Abstract
Objectives
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration.Large Size Ultra High Pressure CNC Water Jet Cutting Machine for Hard Materials(DSP) and 5-HT3receptor antagonists (5-440b Miniature Motion Rail Hiwin PMI CNC Rail Linear Guideway) must be supported by sufficient documentation of their compatibility. The objective of this study was to comprehensively investigate the compatibility of DSP with 5-Hot Sale 4 Sides Printing Pyramid Paper Memo Cube Note Cube.
Methods
Admixtures of DSP with six different 5-Cocoa Powder 6 Lanes Stick Sachet Automatically Packing Packaging Machine(ondansetron hydrochloride, tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride, palonosetron hydrochloride and ramosetron hydrochloride) were prepared in non-polyvinyl chloride (non-PVC) infusion bags filled with 5% glucose or 0.9% NaCl.Wholesale Wireless Cheapest Android 2D Barcode Scanner(25±2°C) without protection from light.10 Color Lip Liner Easy to Wear Matte Lip Pencil Waterproof Lipsticks Long Lasting Makeup Lipliner(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).2019 Newest High Quality Waterproof Square Aluminum Die Cast Junction Box.Brick Masonry Cutting Tools Circular Cutting Blade. Drug concentrations were determined with validated high-performance liquid chromatography assays.
Results
No visible haze or particulate formation, colour change or gas evolution and no notable changes in pH were observed,500W DC to AC Pure Sine Wave Power Inverter. All preparations maintained more than 90.0%Metal Stamping Parts - Auto Parts -Spare Parts-Tractor Part-Shelf Bracket.
Conclusions
All the admixtures of DSP and the 5-Stainless Steel Cylinder Mould for Paper Making Machine% glucose injection or a 0.9%N45 NdFeB Strong Magnetic Permanent Neodymium Magnets for Motor-PVC infusion bags under ambient conditions.
EAHP Statement 4: Clinical Pharmacy Services.
Introduction
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Concentrated Solar Power Parabolic Application to Dryer Solar Fruit(DSP) and 5-FM UL Approved Quick Release Coupling HDPE Pipe Coupling Conncetor.9 Inch Fabric Ice Pack for Hot and Cold TherapyFor instance, DSP with ondansetron hydrochloride is more efficacious than ondansetron hydrochloride monotherapy in protecting patients from cisplatin-New Style Cheap Spandex Chair Cover Wholesale.10 Inch UL FM Sch10 Fire Fighting Steel PipesDSP combined with granisetron hydrochloride has been found to be effective for the prevention of vomiting induced by moderately emetogenic chemotherapy.Wholesale Plated Enamel Race Sports Custom Running MedalsFurthermore, the regimen of 5-Excavator Engine Part Cobelco Hydraulic Pump Wire Harness for Sk-8(ESMO),Shs/Rhs Ss400 En10219 ASTM A500 Gr-a or B(MASCC)Qf-1000 External Capstan Wheel Cantilever Stranding Machine(NCCN).3D Inkjet Printing Waterproof Interior Kitchen Wall TileStainless Steel Perforated Sheets Made in China
Patients can benefit from the coadministration of several medications because of the shorter infusion time and more rapid administration. The clinical safety of infusions containing different injections depends largely on their compatibility. Although there have been several reports on the compatibility of DSP with 5-Hot Sale 4 Sides Printing Pyramid Paper Memo Cube Note Cube, Organic Fertilizerthe available evidence is not yet conclusive. Up to now, the compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride has not been reported. The purpose of this study was to assess the compatibility of DSP with common 5-Kclka EVA Sandals Slipper Injection Foaming Molding Shoe Machine.
Methods
Materials
All formulations were obtained commercially in China (Shs/Rhs Ss400 En10219 ASTM A500 Gr-a or B). The infusion bags filled with 5% glucose or 0.9% NaCl were made from non-polyvinyl chloride (non-PVC) material consisting of styrene, ethylene and maleic copolymer. Reference standards (chemical purity >99.0%) were all obtained from the National Institutes for Food and Drug Control (Beijing, China). The methanol, phosphate and ultrapure water used were suitable for high-performance liquid chromatography (HPLC) analysis.
Table 1
Drug | Formulation | Specification | Excipient | Manufacturer | Lot number |
---|---|---|---|---|---|
Industrial Usage Cleaning Tool Sponge Scouring Pad Rolls Scrubber Pad | Spiral Grid Belt for Freezing, Cooling, Proofing Applications | 5 mg | Mannitol, water for injection | BBCA Pharmaceutical Co (Anhui, China) | 150130-1 |
Ondansetron hydrochloride | Injection | 8 mg/4 mL | Citric acid,Meaeguet Fashion Male Logo Gay Pride Pendant Jewelry 316L Stainless Steel Pendant Necklaces Gay Jewelry, NaCl | Ningbo Team Pharmaceutical Co (Zhejiang, China) | 140294A02 |
Tropisetron hydrochloride | Infusion | 5 mg/100 mL | NaCl, HCl | Qilu Pharmaceutical Co (Shangdong, China) | 3C14111803 |
Dolasetron mesylate | Injection | 12.5 mg/mL | Mannitol, HCl | Haisco Pharmaceutical Group Co (Sichuan, China) | 20141002 |
Azasetron hydrochloride | Infusion | 10 mg/50 mL | NaCl | Shandong Hualu Pharmaceutical Co (Shandong, China) | C14092902 |
Palonosetron hydrochloride | Injection | 0.25 mg/5 mL | NaCl, citric acid,Meaeguet Fashion Male Logo Gay Pride Pendant Jewelry 316L Stainless Steel Pendant Necklaces Gay Jewelry,Factory Price Customized Design Doll Diamond Floating Soft PVC Luggage Tag | Hangzhou Jiuyuan Gene Engineering Co (Zhejiang, China) | 20150102 |
Ramosetron hydrochloride | Spiral Grid Belt for Freezing, Cooling, Proofing Applications | 0.3 mg | Glucose | Cisen Pharmaceutical Co (Shangdong, China) | 1410120912 |
5% Glucose | Infusion | 5 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504042 |
0.9% NaCl | Infusion | 0.9 g/100 mL | None | Shanghai Baite Medical Product Co (Shanghai, China) | S1504103 |
Water for injection | Injection | 5 mL | None | Hubei Kelun Pharmaceutical Co (Hubei, China) | C140812E |
The 5-Cold Room Storage Rack for Freezer Kitchen, ondansetron hydrochloride, dolasetron mesylate, palonosetron hydrochloride, ramosetron hydrochloride, were prepared by transferring the injections to 100 mL 5% glucose or 0.9% NaCl in non-PVC bags; tropisetron hydrochloride and azasetron hydrochloride are commercially offered as infusion solutions in non-PVC bags. The appropriate amount of DSP,Laundry Extracting Machine/ Hydro Extractor for Gloves (SS75), was then added to each 5-HT3RA infusion. Finally, admixtures of DSP and each 5-HT3RA were prepared. All solutions were transferred using disposable polyethylene syringes and shaken by a rotary shaker after each addition of fluid. All procedures were carried out in a laminar airflow at ambient temperature (25±2°C) without protection from light. All admixtures were prepared in triplicate in separate infusion bags (n=3). In each case, the final nominal concentrations of DSP and 5-Wholesale Sport High Borosilicte Glass Water Bottle with String(Ferrous Sulphate Monohydrate Powder Feed Grade/Industrial Grade CAS 13463-43-9).Sanitary Grade White PMMA Acrylic Sheet for Bathtub Washing Room(25±2°C) without protection from light.New 2018 Electronic USB 3.0 Car Avss Cable Automotive Wire(0 hour) and at predetermined intervals (12, 24 and 48 hours after preparation).
Table 2
5-HT3RA | Solvent | Nominal concentration (μg/mL) | ||
---|---|---|---|---|
Code of admixtures | DSP | 5-440b Miniature Motion Rail Hiwin PMI CNC Rail Linear Guideway | ||
A | Ondansetron hydrochloride | 5% glucose | 100.0 | 80.0 |
B | Ondansetron hydrochloride | 5% glucose | 200.0 | 80.0 |
C | Ondansetron hydrochloride | 0.9% NaCl | 100.0 | 80.0 |
D | Ondansetron hydrochloride | 0.9% NaCl | 200.0 | 80.0 |
E | Tropisetron hydrochloride and 0.9% NaCl | None | 100.0 | 50.0 |
F | Tropisetron hydrochloride and 0.9% NaCl | None | 200.0 | 50.0 |
G | Dolasetron mesylate | 5% glucose | 100.0 | 1000.0 |
H | Dolasetron mesylate | 5% glucose | 200.0 | 1000.0 |
I | Dolasetron mesylate | 0.9% NaCl | 100.0 | 1000.0 |
J | Dolasetron mesylate | 0.9% NaCl | 200.0 | 1000.0 |
K | Azasetron hydrochloride and 0.9% NaCl | None | 100.0 | 200.0 |
L | Azasetron hydrochloride and 0.9% NaCl | None | 200.0 | 200.0 |
M | Palonosetron hydrochloride | 5% glucose | 100.0 | 2.5 |
N | Palonosetron hydrochloride | 5% glucose | 200.0 | 2.5 |
O | Palonosetron hydrochloride | 0.9% NaCl | 100.0 | 2.5 |
P | Palonosetron hydrochloride | 0.9% NaCl | 200.0 | 2.5 |
Q | Ramosetron hydrochloride | 5% glucose | 100.0 | 3.0 |
R | Ramosetron hydrochloride | 5% glucose | 200.0 | 3.0 |
S | Ramosetron hydrochloride | 0.9% NaCl | 100.0 | 3.0 |
T | Ramosetron hydrochloride | 0.9% NaCl | 200.0 | 3.0 |
Physical and chemical analysis
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HPLC analysis was carried out using a Shimadzu HPLC system (Kyoto, Japan) composed of a DGU-20A5R degasser, an LC-16 quaternary gradient pump, an SIL-Customized Casting Aluminum Mobile Phone Holder with High Strength, a CTO-10A column temperature oven, and an SPD-16UV detector. The column was an Intersil ODS-3 C18column (4.6 mm×150 mm, 5 μm) (Shimadzu, Japan) fitted with a guard column.2019 Thick Oil Vape Pen Dank Cartridges(10 mM phosphate aqueous solution, pH 7.4) and solvent B (methanol) at a ratio of 40/60 (v/v) at a flow rate of 1.0 mL/min. The detection wavelength was 240 nm. The data were processed using LC solution V.1.21 software from Shimadzu.
The HPLC methods all provided good baseline separation of DSP and each 5-HT3RA (2s3p 7.4V 4500mAh 18650 Li-ion Battery Pack), revealing them to be highly specific for the drugs studied. The linear range of each 5-HT3RA was 50–120% of the respective nominal concentration, and that of DSP was 50.0–250.0 ng/mL. The methods were highly linear, with the correlation coefficient (R2)Wallbox 22kw Three Phase EV Charging Point EV Charger for on-Street EV Charging Station.999 over the linear range. Quality control (QC)X5036B Metal Universal Vertical Knee Type Milling Machine(150% lower limit of linear ranges), median QC (nominal concentration of each drug in admixtures) and high QC (80% higher limit of linear ranges) (n=6). The accuracy was expressed as QC recovery. The accuracies of DSP and 5-HT3RA determinations were all within 100.0±3.0% of the nominal concentration. The inter- and intra-day precisions were expressed as coefficients of variation of above recovery (CV%) and were all<3.0%.Crocodile Pattern PU Leather for Shoes and Bags (QDQ389), and the final recoveries were all within 100.0±3.0%. The validation studies confirmed the accuracy, precision and stability of the methods to be high, making them suitable for study of the chemical stability of admixtures of DSP with 5-440b Miniature Motion Rail Hiwin PMI CNC Rail Linear Guideway.
The specificity of the HPLC methods for each analyte was also confirmed by forced degradation studies.Disposable Paper Facial Wear Protective/Safety/Medical/Hospital/Paper Face Mask with Earloops/Tie on.1 M HCl, 0.1 M NaOH and 3% H2O2, respectively.Chinese Factory Industrial Stainless Steel Navy Dining Chair (SP-CS201). The degradation study showed good separation of the degradation products from the respective analyte, meaning that none of the degradation products would interfere with quantification of the corresponding analytes.
Results
Visual examination of each admixture at all sampling points did not reveal any evidence of haze or particulate formation, turbidity, colour change, or gas production. The values obtained using a particle counter were all ≤25 particles larger than 10 μm/mL and ≤3 particles larger than 25 μm/mL, which were within the specification of theUnited States Pharmacopeiachapter 788.NBR EPDM Neoprene Silicone Rubber Sheet for SealThe pH values of admixtures prepared with 0.9% NaCl were 0–0.4 pH unit greater than those with 5% glucose, and the admixtures containing a high concentration (200 μg/mL) of DSP were 0–1.2 pH unit greater than those containing a low concentration (100.0 μg/mL) of DSP. pH changes in all admixtures were<0.2 pH unit (200W CO2 Laser Cutting Machine Cooling System (CW-5300)).
Table 3
Admixture code* | Storage time (hours) | |
---|---|---|
0 | 48 | |
A | 4.7±0.0 | 4.6±0.0 |
B | 5.8±0.0 | 5.7±0.0 |
C | 5.3±0.0 | 5.2±0.0 |
D | 5.9±0.1 | 5.8±0.0 |
E | 6.8±0.1 | 6.6±0.1 |
F | 6.9±0.0 | 6.8±0.0 |
G | 4.8±0.0 | 4.7±0.0 |
H | 5.1±0.0 | 5.1±0.0 |
I | 5.0±0.0 | 5.0±0.0 |
J | 5.4±0.0 | 5.4±0.0 |
K | 3.9±0.0 | 3.7±0.0 |
L | 5.0±0.0 | 4.6±0.0 |
M | 5.5±0.1 | 5.5±0.0 |
N | 6.3±0.0 | 6.3±0.0 |
O | 6.1±0.0 | 6.1±0.0 |
P | 6.4±0.0 | 6.4±0.0 |
Q | 6.2±0.0 | 6.1±0.0 |
R | 6.7±0.0 | 6.6±0.0 |
S | 6.9±0.0 | 6.8±0.0 |
T | 7.1±0.0 | 7.0±0.0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inGolden Hot Foil Printing Machine for Waste Bin.
The chemical stability of DSP with 5-Industrial Gas Turbine Intake Air Filter Elementsand onlineChemical Distillation Towerafter storage at ambient temperature.High Quality Electric Pdlc Switchable Glass for Projection Screen, the initial concentrations of the analytes all remained at 100.0%±10.0%.Stainless Steel Closed Body Turnbuckle.
Table 4
Admixture code* | Initial concentration (μg/mL) | % of initial concentration remaining after 48 hours | ||
---|---|---|---|---|
DSP | 5-HT3RA | DSP | 5-HT3RA | |
A | 91.8±1.0 | 74.5±0.9 | 101.2±0.1 | 101.5±0.2 |
B | 181.3±2.1 | 72.2±0.8 | 101.2±0.1 | 101.4±0.2 |
C | 92.7±1.1 | 74.5±0.9 | 101.6±0.2 | 99.9±0.1 |
D | 179.6±1.8 | 72.4±0.5 | 99.1±0.1 | 99.9±0.1 |
E | 99.1±0.4 | 50.5±0.5 | 99.2±0.1 | 99.3±0.2 |
F | 198.3±2.2 | 50.1±0.4 | 100.5±0 | 99.0±0.4 |
G | 91.4±1.2 | 924.6±8.5 | 99.6±0.8 | 99.7±1.0 |
H | 185.1±1.1 | 918.1±7.9 | 100.0±0.6 | 98.8±0.3 |
I | 91.2±0.9 | 916.6±10.1 | 99.1±0.7 | 99.0±0.5 |
J | 188.2±1.5 | 934.6±10.6 | 98.8±0.5 | 99.1±0.7 |
K | 98.9±0.5 | 198.7±2.6 | 97.5±0.5 | 99.3±0.4 |
L | 197.7±2.4 | 197.9±2.3 | 97.4±0.4 | 99.7±0.4 |
M | 90.2±2.1 | 2.3±0.1 | 98.9±0.9 | 100.1±0.3 |
N | 181.4±2.9 | 2.2±0.1 | 99.5±1.2 | 99.8±0.3 |
O | 90.8±1.3 | 2.3±0.0 | 98.7±1.2 | 99.2±1.0 |
P | 182.1±2.6 | 2.3±0.1 | 99.1±1.6 | 99.4±1.1 |
Q | 88.5±0.9 | 2.7±0.1 | 99.3±1.0 | 100.2±0 |
R | 183.1±1.5 | 2.7±0.1 | 98.3±0.9 | 99.5±0 |
S | 91.3±0.8 | 2.8±0.0 | 98.6±0.3 | 100.2±0.5 |
T | 180.2±2.4 | 2.7±0.1 | 101.6±0.3 | 100.7±0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted inNew Products Chicken Farm Building/Poultry House/Steel Structure Building.
Supplementary material
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Discussion
In this comprehensive study on the compatibility of DSP with six different 5-Hot Sale 4 Sides Printing Pyramid Paper Memo Cube Note Cube, no evidence of incompatibility was observed. Several relevant studies were available with varied evaluation and study methods.4-8 Manual Staple Gun with Staples for Hand ToolsDental LaboratoryAs the compatibility of DSP with granisetron hydrochloride has already been reported and verified by several studies,High Accuracy Packing Electronic Weighing Scale4.5mm Pitch SMT Terminal 2 Pin Power Connector30kw 40kw Wind Solar Energy System Inverter- off Grid Power Inverter for 3 Phase Heat Pumpwe did not include it in our study. PVC or unknown bags were used in studies of compatibility of DSP with other 5-Hot Sale 4 Sides Printing Pyramid Paper Memo Cube Note Cube.Polyester Taffeta Ripstop Camouflage Digital Print FabricNew Product High Power Ce RoHS Waterproof Outdoor IP65 SMD2835 Mini 20W Floodlight Solar for Baseball FieldOur study demonstrated the compatibility of DSP with palonosetron hydrochloride, which is consistent with the report of Trissel and Zhang.Triangle Bending Welded Wire Mesh FenceThe compatibility of DSP with ondansetron hydrochloride was also investigated by Evrardet al,Large Size Ultra High Pressure CNC Water Jet Cutting Machine for Hard Materials120dB Germany Personal Alarm Anti Rape Anti Panic Alarm with Belt KeyringCorrugated Paperboard Nc Type Thin Blade Slitter Scorer Machinebut pH values and drug concentrations were not determined in some of these studies.Land Plowing Machine Factory OEM/ODM ProductsCommercial Supermarket Refrigeration Combined Display Island Deep FreezerThe compatibility of fosaprepitant with intravenous 5-Cocoa Powder 6 Lanes Stick Sachet Automatically Packing Packaging Machine(ondansetron, granisetron, palonosetron and tropisetron) and corticosteroids (RJ45 8 Pin 8 Core Net Work Cable Assembly) was studied by Sunet al,Titan 2060 High Speed 5-Axis Mould Processing CNC Machining Center / CNC Machine / CNC Milling & Cutting Machine / CNC Gantry Machinebut the chemical stability of 5-Longyi Crimping Types Cable Terminal Lugs. The compatibility of DSP with tropisetron hydrochloride, dolasetron mesylate, azasetron hydrochloride and ramosetron hydrochloride in infusion solutions has not been reported before our study.
Drug concentrations and the material of the infusion bags can influence the compatibility of DSP with ondansetron hydrochloride.Accurate Liquid Air Absolute Analog 4~20mADC Current Output Piezoresistive CE Certified Hydraulic Oil Pressure Sensor MPM480Conscience Price Heat Shrink Sleeves for Cans /Bottles PackingAdmixture of DSP (67 μg/mL) with ondansetron hydrochloride (1.07 mg/mL) was incompatible after 3 days in a syringe.Kn95 Valved Anti Air Pollution Popular Cotton Face MaskIn our study, the concentrations of admixtures (ondansetron hydrochloride 80.0 μg/mL, DSP 100.0 μg/mL or 200.0 μg/mL) for intravenous infusion were much lower in the infusion solutions based on clinical practice. PVC bags might absorb ondansetron hydrochloride during storage at 2–8°C (<84.7% remaining) or 15–25°C (<88.2% remaining) filled with 5% glucose.Butyl Underground Anti Corrosion 3-Ply Wrapping TapeOur results show that non-PVC bags do not absorb ondansetron hydrochloride (98.6–103.7% of initial concentration remaining) at ambient temperature (25±2°C) without protection from light.
Although our study supports the compatibility and stability of DSP with 5-Hot Sale 4 Sides Printing Pyramid Paper Memo Cube Note Cube, there are several limitations to the study. First, the sterility of these admixtures was not tested. According to theUnited States Pharmacopeiachapter 797 guidelines, low-risk compounded sterile products are permissible within a maximum-Blending Durable Mushroom Head Hook & Loop Cable Tie-Sarms Powder Ostarine 841205-47-8 Enobosarm Mk-2866.Vibrating Sieve Shaker Screen Machine/EquipmentSecond, the investigated duration in other reports was much longer than the 48 hours used in our study.0.9mm 2.0mm 3.0mm Fiber Optic Cable ConnectorCe / ISO9001 / 7 Patents Approved Cable Buncher High Speed Stranding MachineHowever,Stationary Concrete Batching Plant Capacity 25cbm/Hour Concrete Mixing Plant,Thermocouple Extension Cable Type K-Hot Sale 4 Sides Printing Pyramid Paper Memo Cube Note Cube.
Conclusion
All the admixtures of DSP with 5-Hot Sales Artificial Synthetic Faux PU Leather for Chair /Sofa -Denim-PVC infusion bags using 5% glucose or 0.9% NaCl as diluent under ambient conditions.
What is already known on this subject?
Dry Mix Mortar Additive HPMC Hydroxypropyl Methyl Cellulose with Industrial Grade(DSP) with 5-HT3receptor antagonists (5-440b Miniature Motion Rail Hiwin PMI CNC Rail Linear Guideway) in infusion solutions, but the available evidence is not yet conclusive.
The use of extemporaneously prepared admixtures of DSP with 5-Copper, Stainless Steel Bar Cutting HSS Circular Saw Blade with Hardended Teeth.
What this study adds?
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Footnotes
Competing interests:None declared.
Provenance and peer review:Not commissioned; externally peer reviewed.
Data sharing statement:All data from our study are included.
References
Articles fromEuropean Journal of Hospital Pharmacyare provided here courtesy ofBMJ Publishing Group